Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

Cell

Volumn 171, Issue 7, 2017, Pages 1611-1624.e24

  Puram, Sidharth V ^a,b,c,d   Tirosh, Itay ^b,e   Parikh, Anuraag S ^a,b,c,d   Patel, Anoop P ^a,b   Yizhak, Keren ^a,b   Gillespie, Shawn ^a,b   Rodman, Christopher ^b   Luo, Christina L ^a   Mroz, Edmund A ^c,d,f   Emerick, Kevin S ^c,d   Deschler, Daniel G ^c,d   Varvares, Mark A ^c,d   Mylvaganam, Ravi ^a   Rozenblatt Rosen, Orit ^b   Rocco, James W ^c,d,f   Faquin, William C ^a   Lin, Derrick T ^c,d   Regev, Aviv ^b,g,h   Bernstein, Bradley E ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^f OHIO STATE UNIVERSITY   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

epithelial to mesenchymal transition; head and neck squamous cell carcinoma; intra tumoral heterogeneity; metastasis; scRNA seq; single cell RNA sequencing; tumor microenvironment

Indexed keywords

TRANSCRIPTOME;

ADULT; AGED; ARTICLE; CANCER GRADING; CELL CYCLE; CELL HYPOXIA; CELL STRESS; COHORT ANALYSIS; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; LYMPH NODE METASTASIS; MALE; METASTASIS; MIDDLE AGED; PRIMARY TUMOR; PRIORITY JOURNAL; SINGLE CELL ANALYSIS; STROMA CELL; TRANSCRIPTOMICS; TUMOR MICROENVIRONMENT; VERY ELDERLY; CELL CULTURE; GENE EXPRESSION PROFILING; GENETICS; HEAD AND NECK TUMOR; PATHOLOGY; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELLS, CULTURED; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION PROFILING; HEAD AND NECK NEOPLASMS; HUMANS; MALE; NEOPLASM METASTASIS; SINGLE-CELL ANALYSIS; TUMOR MICROENVIRONMENT;

EID: 85035813065     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.10.044     Document Type: Article

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