Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

Journal of Extracellular Vesicles

Volumn 6, Issue 1, 2017, Pages

  Zhu, Xiaohua ^a   Badawi, Mohamed ^a   Pomeroy, Steven ^b   Sutaria, Dhruvitkumar S ^a   Xie, Zhiliang ^a   Baek, Alice ^a   Jiang, Jinmai ^b   Elgamal, Ola A ^a   Mo, Xiaokui ^a   Perle, Krista La ^a   Chalmers, Jeffrey ^c   Schmittgen, Thomas D ^b   Phelps, Mitch A ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

^c The Ohio State University   (United States)

Author keywords

C57BL 6; cytokines; drug carriers; Exosomes; immunogenicity; immunophenotyping; miR 199a 3p; toxicity

Indexed keywords

BIOLOGICAL MARKER; CHIMERIC PROTEIN; MICRORNA; MICRORNA 199A 3P; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD CHEMISTRY; BLOOD SAMPLING; C57BL 6 MOUSE; CELL ENGINEERING; CLINICAL EVALUATION; CONTROLLED STUDY; EXOSOME; FEMALE; HEK293T CELL LINE; HEMATOLOGY; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; SPLEEN CELL; SURGICAL TECHNIQUE; TOXICITY; WILD TYPE;

EID: 85034054886     PISSN: None     EISSN: 20013078     Source Type: Journal    
DOI: 10.1080/20013078.2017.1324730     Document Type: Article

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