Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Journal of Extracellular Vesicles

Volumn 6, Issue 1, 2017, Pages

  Sutaria, Dhruvitkumar S ^a,b   Jiang, Jinmai ^a   Elgamal, Ola A ^a,b   Pomeroy, Steven M ^a   Badawi, Mohamed ^b   Zhu, Xiaohua ^b   Pavlovicz, Ryan ^b   Azevedo Pouly, Ana Clara P ^b   Chalmers, Jeffrey ^c   Li, Chenglong ^b   Phelps, Mitch A ^b   Schmittgen, Thomas D ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c The Ohio State University   (United States)

Author keywords

Exosomes; hepatocellular cancer; HIV 1 TAR RNA; microRNA mimic; shRNA; small hairpin RNA; TAT peptide

Indexed keywords

DICER; HYBRID PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MICRORNA; MICRORNA 199A; PEPTIDE; RECOMBINANT PROTEIN; RNA PRECURSOR; TRANSACTIVATION RESPONSE RNA INTERACTING PEPTIDE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ENGINEERING; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENZYME BINDING; EXOSOME; GEL MOBILITY SHIFT ASSAY; GENETIC ASSOCIATION; HEK293T CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRON; LUCIFERASE ASSAY; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PROTEIN PROCESSING; PROTEIN RNA BINDING; SYNTHESIS; VIRAL GENE DELIVERY SYSTEM;

EID: 85033493022     PISSN: None     EISSN: 20013078     Source Type: Journal    
DOI: 10.1080/20013078.2017.1333882     Document Type: Article

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