Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151

International Journal of Oncology

Volumn 49, Issue 5, 2016, Pages 2037-2045

  Kim, Ji Hye ^a   Badawi, Mohamed ^a   Park, Jong Kook ^a,d   Jiang, Jinmai ^a,c   Mo, Xiaokui ^a   Roberts, Lewis R ^b   Schmittgen, Thomas D ^a,c  

^a OHIO STATE UNIVERSITY   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Liver; Metastasis; MicroRNA; MiR 199a; Tspan24

Indexed keywords

CD151 ANTIGEN; MESSENGER RNA; MESSENGER RNA 199A 3P; MICRORNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; MIRN199 MICRORNA, HUMAN;

ADULT; AGED; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CD151 GENE; CELL MIGRATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CELL CARCINOMA; MALE; MESENCHYME CELL; METASTASIS; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TUMOR INVASION; VERY ELDERLY; APOPTOSIS; CELL MOTION; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; LIVER; LIVER TUMOR; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD151; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; LIVER; LIVER NEOPLASMS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM INVASIVENESS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84992677803     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2016.3677     Document Type: Article

References (28)

1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136: E359-E386, 2015.
2. Raoul JL, Sangro B, Forner A, Mazzaferro V, Piscaglia F, Bolondi L and Lencioni R: Evolving strategies for the management of intermediate-stage hepatocellular carcinoma: Available evidence and expert opinion on the use of transarterial chemoembolization. Cancer Treat Rev 37: 212-220, 2011.
3. Aravalli RN, Steer CJ and Cressman EN: Molecular mechanisms of hepatocellular carcinoma. Hepatology 48: 2047-2063, 2008.
4. Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866, 2006.
5. Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG, Calin GA, Giovannini C, Ferrazzi E, Grazi GL, et al: Cyclin G1 is a target of miR-122a, a microRNA frequently downregulated in human hepatocellular carcinoma. Cancer Res 67: 6092-6099, 2007.
6. Hou J, Lin L, Zhou W, Wang Z, Ding G, Dong Q, Qin L, Wu X, Zheng Y, Yang Y, et al: Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell 19: 232-243, 2011.
7. Jiang J, Gusev Y, Aderca I, Mettler TA, Nagorney DM, Brackett DJ, Roberts LR and Schmittgen TD: Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res 14: 419-427, 2008.
8. Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T and Shimotohno K: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 25: 2537-2545, 2006.
9. Fornari F, Milazzo M, Chieco P, Negrini M, Calin GA, Grazi GL, Pollutri D, Croce CM, Bolondi L and Gramantieri L: MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res 70: 5184-5193, 2010.
10. Kim S, Lee UJ, Kim MN, Lee EJ, Kim JY, Lee MY, Choung S, Kim YJ and Choi YC: MicroRNA miR-199a∗ regulates the MET proto-oncogene and the downstream extracellular signalregulated kinase 2 (ERK2). J Biol Chem 283: 18158-18166, 2008.
11. Henry JC, Park JK, Jiang J, Kim JH, Nagorney DM, Roberts LR, Banerjee S and Schmittgen TD: miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun 403: 120-125, 2010.
12. Ke AW, Shi GM, Zhou J, Wu FZ, Ding ZB, Hu MY, Xu Y, Song ZJ, Wang ZJ, Wu JC, et al: Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma. Hepatology 49: 491-503, 2009.
13. Shi GM, Ke AW, Zhou J, Wang XY, Xu Y, Ding ZB, Devbhandari RP, Huang XY, Qiu SJ, Shi YH, et al: CD151 modulates expression of matrix metalloproteinase 9 and promotes neoangiogenesis and progression of hepatocellular carcinoma. Hepatology 52: 183-196, 2010.
14. Ke AW, Shi GM, Zhou J, Huang XY, Shi YH, Ding ZB, Wang XY, Devbhandari RP and Fan J: CD151 amplifies signaling by integrin alpha6beta1 to PI3K and induces the epithelial-mesenchymal transition in HCC cells. Gastroenterology 140: 1629-1641 e15, 2011.
15. Klosek SK, Nakashiro K, Hara S, Shintani S, Hasegawa H and Hamakawa H: CD151 forms a functional complex with c-Met in human salivary gland cancer cells. Biochem Biophys Res Commun 336: 408-416, 2005.
16. Arora H, Qureshi R and Park WY: miR-506 regulates epithelial mesenchymal transition in breast cancer cell lines. PLoS One 8: e64273, 2013.
17. Han ZB, Yang Z, Chi Y, Zhang L, Wang Y, Ji Y, Wang J, Zhao H and Han ZC: MicroRNA-124 suppresses breast cancer cell growth and motility by targeting CD151. Cell Physiol Biochem 31: 823-832, 2013.
18. Wang X, Yu H, Lu X, Zhang P, Wang M and Hu Y: MiR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151. Biochem Biophys Res Commun 445: 175-179, 2014.
19. Tirmenstein MA, Nicholls-Grzemski FA, Schmittgen TD, Zakrajsek BA and Fariss MW: Characterization of nitric oxide production following isolation of rat hepatocytes. Toxicol Sci 53: 56-62, 2000.
20. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR, et al: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33: e179, 2005.
21. Gebäck T, Schulz MM, Koumoutsakos P and Detmar M: TScratch: A novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques 46: 265-274, 2009.
22. Duan Q, Wang X, Gong W, Ni L, Chen C, He X, Chen F, Yang L, Wang P and Wang DW: ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer. PLoS One 7: e31518, 2012.
23. Shi KQ, Lin Z, Chen XJ, Song M, Wang YQ, Cai YJ, Yang NB, Zheng MH, Dong JZ, Zhang L, et al: Hepatocellular carcinoma associated microRNA expression signature: Integrated bioinformatics analysis, experimental validation and clinical significance. Oncotarget 6: 25093-25108, 2015.
24. Sadej R, Grudowska A, Turczyk L, Kordek R and Romanska HM: CD151 in cancer progression and metastasis: A complex scenario. Lab Invest 94: 41-51, 2014.
25. Johnson JL, Winterwood N, DeMali KA and Stipp CS: Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts. J Cell Sci 122: 2263-2273, 2009.
26. DeLong RK, Nolting A, Fisher M, Chen Q, Wickstrom E, Kligshteyn M, Demirdji S, Caruthers M and Juliano RL: Comparative pharmacokinetics, tissue distribution, and tumor accumulation of phosphorothioate, phosphorodithioate, and methylphosphonate oligonucleotides in nude mice. Antisense Nucleic Acid Drug Dev 7: 71-77, 1997.
27. Murakami Y, Aly HH, Tajima A, Inoue I and Shimotohno K: Regulation of the hepatitis C virus genome replication by miR-199a. J Hepatol 50: 453-460, 2009.
28. Zhang GL, Li YX, Zheng SQ, Liu M, Li X and Tang H: Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. Antiviral Res 88: 169-175, 2010.