메뉴 건너뛰기




Volumn 2, Issue , 2017, Pages

Next-generation probiotics: The spectrum from probiotics to live biotherapeutics

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 10; INTERLEUKIN 2; PROBIOTIC AGENT; TRANSFORMING GROWTH FACTOR BETA1;

EID: 85019614311     PISSN: None     EISSN: 20585276     Source Type: Journal    
DOI: 10.1038/nmicrobiol.2017.57     Document Type: Review
Times cited : (645)

References (53)
  • 1
    • 84905675648 scopus 로고    scopus 로고
    • Expert consensus document. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic
    • Hill, C. et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 11, 506-514 (2014).
    • (2014) Nat. Rev. Gastroenterol. Hepatol. , vol.11 , pp. 506-514
    • Hill, C.1
  • 2
    • 84988847546 scopus 로고    scopus 로고
    • Statement on the update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA. 2: Suitability of taxonomic units notified to EFSA until March 2015
    • EFSA
    • EFSA. Statement on the update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA. 2: suitability of taxonomic units notified to EFSA until March 2015. EFSA J. 13, 4138 (2015).
    • (2015) EFSA J. , vol.13 , pp. 4138
  • 3
    • 84962376125 scopus 로고    scopus 로고
    • Patent watch: Modulating the human microbiome with live biotherapeutic products: Intellectual property landscape
    • Sun, X., Fiala, J. L. & Lowery, D. Patent watch: modulating the human microbiome with live biotherapeutic products: intellectual property landscape. Nat. Rev. Drug. Discov. 15, 224-225 (2016).
    • (2016) Nat. Rev. Drug. Discov. , vol.15 , pp. 224-225
    • Sun, X.1    Fiala, J.L.2    Lowery, D.3
  • 4
    • 84977491722 scopus 로고    scopus 로고
    • A novel strain of bacteroides fragilis enhances phagocytosis and polarises M1 macrophages
    • Deng, H. M. et al. A novel strain of Bacteroides fragilis enhances phagocytosis and polarises M1 macrophages. Sci. Rep. 6, 29401 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 29401
    • Deng, H.M.1
  • 5
    • 0032037637 scopus 로고    scopus 로고
    • Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic bacteroides fragilis
    • Moncrief, J. S., Duncan, A. J., Wright, R. L., Barroso, L. A. & Wilkins, T. D. Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic Bacteroides fragilis. Infect. Immun. 66, 1735-1739 (1998).
    • (1998) Infect. Immun. , vol.66 , pp. 1735-1739
    • Moncrief, J.S.1    Duncan, A.J.2    Wright, R.L.3    Barroso, L.A.4    Wilkins, T.D.5
  • 6
    • 1842289171 scopus 로고    scopus 로고
    • The bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells
    • Obiso, R. J. Jr., Azghani, A. O. & Wilkins, T. D. The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells. Infect. Immun. 65, 1431-1439 (1997).
    • (1997) Infect. Immun. , vol.65 , pp. 1431-1439
    • Obiso, R.J.1    Azghani, A.O.2    Wilkins, T.D.3
  • 7
    • 84889077521 scopus 로고    scopus 로고
    • Substrate cleavage profiling suggests a distinct function of bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface
    • Shiryaev, S. A. et al. Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface. J. Biol. Chem. 288, 34956-34967 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 34956-34967
    • Shiryaev, S.A.1
  • 8
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian, S. K., Liu, C. H., Tzianabos, A. O. & Kasper, D. L. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122, 107-118 (2005).
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 10
    • 84988909614 scopus 로고    scopus 로고
    • Impact of oral consumption of heat-treated bacteroides xylanisolvens DSM 23964 on the level of natural TFα-specific antibodies in human adults
    • Ulsemer, P. et al. Impact of oral consumption of heat-treated Bacteroides xylanisolvens DSM 23964 on the level of natural TFα-specific antibodies in human adults. Benef. Microbes 7, 485-500 (2016).
    • (2016) Benef. Microbes , vol.7 , pp. 485-500
    • Ulsemer, P.1
  • 12
    • 80053516398 scopus 로고    scopus 로고
    • Inhibition of the cytotoxic effect of clostridium difficile in vitro by clostridium butyricum MIYAIRI 588 strain
    • Woo, T. D. et al. Inhibition of the cytotoxic effect of Clostridium difficile in vitro by Clostridium butyricum MIYAIRI 588 strain. J. Med. Microbiol. 60, 1617-1625 (2011).
    • (2011) J. Med. Microbiol. , vol.60 , pp. 1617-1625
    • Woo, T.D.1
  • 13
    • 31144447912 scopus 로고    scopus 로고
    • Effect of clostridium butyricum on fecal flora in helicobacter pylori eradication therapy
    • Shimbo, I. et al. Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy. World J. Gastroenterol. 11, 7520-7524 (2005).
    • (2005) World J. Gastroenterol. , vol.11 , pp. 7520-7524
    • Shimbo, I.1
  • 14
    • 0020600434 scopus 로고
    • Cholesterol-lowering effect of clostridium butyricum in cholesterol-fed rats
    • Kobashi, K., Takeda, Y., Itoh, H. & Hase, J. Cholesterol-lowering effect of Clostridium butyricum in cholesterol-fed rats. Digestion 26, 173-178 (1983).
    • (1983) Digestion , vol.26 , pp. 173-178
    • Kobashi, K.1    Takeda, Y.2    Itoh, H.3    Hase, J.4
  • 15
    • 0020693597 scopus 로고
    • Effect of clostridium butyricum on the formation and dissolution of gallstones in experimental cholesterol cholelithiasis
    • Takeda, Y., Itoh, H. & Kobashi, K. Effect of Clostridium butyricum on the formation and dissolution of gallstones in experimental cholesterol cholelithiasis. Life Sci. 32, 541-546 (1983).
    • (1983) Life Sci. , vol.32 , pp. 541-546
    • Takeda, Y.1    Itoh, H.2    Kobashi, K.3
  • 16
    • 84873636695 scopus 로고    scopus 로고
    • Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8
    • Shinnoh, M. et al. Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8. Int. J. Oncol. 42, 903-911 (2013).
    • (2013) Int. J. Oncol. , vol.42 , pp. 903-911
    • Shinnoh, M.1
  • 17
    • 55949124035 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    • Sokol, H. et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc. Natl Acad. Sci. USA 105, 16731-16736 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 16731-16736
    • Sokol, H.1
  • 18
    • 84953252234 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses
    • Rossi, O. et al. Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses. Sci. Rep. 6, 18507 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 18507
    • Rossi, O.1
  • 19
    • 84907484487 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii inhibits interleukin-17 to ameliorate colorectal colitis in rats
    • Zhang, M. et al. Faecalibacterium prausnitzii inhibits interleukin-17 to ameliorate colorectal colitis in rats. PLoS ONE 9, e109146 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e109146
    • Zhang, M.1
  • 20
    • 84868288692 scopus 로고    scopus 로고
    • Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis
    • Motta, J. P. et al. Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis. Sci. Transl. Med. 4, 158ra144 (2012).
    • (2012) Sci. Transl. Med. , vol.4 , pp. 158ra144
    • Motta, J.P.1
  • 21
    • 34047124665 scopus 로고    scopus 로고
    • Oral administration of an IL-10-secreting lactococcus lactis strain prevents food-induced IgE sensitization
    • Frossard, C. P., Steidler, L. & Eigenmann, P. A. Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization. J. Allergy Clin. Immunol. 119, 952-959 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.119 , pp. 952-959
    • Frossard, C.P.1    Steidler, L.2    Eigenmann, P.A.3
  • 22
    • 77953359952 scopus 로고    scopus 로고
    • AG013, a mouth rinse formulation of lactococcus lactis secreting human trefoil factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis
    • Caluwaerts, S. et al. AG013, a mouth rinse formulation of Lactococcus lactis secreting human trefoil factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis. Oral Oncol. 46, 564-570 (2010).
    • (2010) Oral Oncol. , vol.46 , pp. 564-570
    • Caluwaerts, S.1
  • 23
    • 84906827511 scopus 로고    scopus 로고
    • Recombinant lactococcus lactis can make the difference in antigen-specific immune tolerance induction, the type 1 diabetes case
    • Robert, S. & Steidler, L. Recombinant Lactococcus lactis can make the difference in antigen-specific immune tolerance induction, the type 1 diabetes case. Microb. Cell Fact. 13(Suppl 1), S11 (2014).
    • (2014) Microb. Cell Fact. , vol.13 , pp. S11
    • Robert, S.1    Steidler, L.2
  • 24
    • 17644378995 scopus 로고    scopus 로고
    • Engineering of the gut commensal bacterium bacteroides ovatus to produce and secrete biologically active murine interleukin-2 in response to xylan
    • Farrar, M. D. et al. Engineering of the gut commensal bacterium Bacteroides ovatus to produce and secrete biologically active murine interleukin-2 in response to xylan. J. Appl. Microbiol. 98, 1191-1197 (2005).
    • (2005) J. Appl. Microbiol. , vol.98 , pp. 1191-1197
    • Farrar, M.D.1
  • 25
    • 77950799444 scopus 로고    scopus 로고
    • Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium bacteroides ovatus
    • Hamady, Z. Z. et al. Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus. Gut 59, 461-469 (2010).
    • (2010) Gut , vol.59 , pp. 461-469
    • Hamady, Z.Z.1
  • 26
    • 80051504591 scopus 로고    scopus 로고
    • Treatment of colitis with a commensal gut bacterium engineered to secrete human TGF-β1 under the control of dietary xylan 1
    • Hamady, Z. Z. et al. Treatment of colitis with a commensal gut bacterium engineered to secrete human TGF-β1 under the control of dietary xylan 1. Inflamm. Bowel Dis. 17, 1925-1935 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 1925-1935
    • Hamady, Z.Z.1
  • 27
    • 55549088221 scopus 로고    scopus 로고
    • Identification and use of the putative bacteroides ovatus xylanase promoter for the inducible production of recombinant human proteins
    • Hamady, Z. Z. et al. Identification and use of the putative Bacteroides ovatus xylanase promoter for the inducible production of recombinant human proteins. Microbiology 154, 3165-3174 (2008).
    • (2008) Microbiology , vol.154 , pp. 3165-3174
    • Hamady, Z.Z.1
  • 28
    • 34147219282 scopus 로고    scopus 로고
    • Regulation (EC) no 1924/2006 of the european parliament and of the council of 20 December 2006 on nutrition and health claims made on foods
    • EC
    • EC. Regulation (EC) no 1924/2006 of the European Parliament and of the Council of 20 December 2006 on nutrition and health claims made on foods. OJ L. 404, 9-25 (2013).
    • (2013) OJ L. , vol.404 , pp. 9-25
  • 32
    • 84961208299 scopus 로고    scopus 로고
    • Advancing probiotic research in humans in the United States: Challenges and strategies
    • Sanders, M. E., Shane, A. L. & Merenstein, D. J. Advancing probiotic research in humans in the United States: challenges and strategies. Gut Microbes 7, 97-100 (2016).
    • (2016) Gut Microbes , vol.7 , pp. 97-100
    • Sanders, M.E.1    Shane, A.L.2    Merenstein, D.J.3
  • 34
    • 84877249773 scopus 로고    scopus 로고
    • Medicines from microbiota
    • Olle, B. Medicines from microbiota. Nat. Biotechnol. 31, 309-315 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 309-315
    • Olle, B.1
  • 35
    • 84873019302 scopus 로고    scopus 로고
    • Duodenal infusion of donor feces for recurrent clostridium difficile
    • van Nood, E. et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N. Engl. J. Med. 368, 407-415 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 407-415
    • Van Nood, E.1
  • 36
    • 84898778719 scopus 로고    scopus 로고
    • From stool transplants to next-generation microbiota therapeutics
    • Petrof, E. O. & Khoruts, A. From stool transplants to next-generation microbiota therapeutics. Gastroenterol. 146, 1573-1582 (2014).
    • (2014) Gastroenterol. , vol.146 , pp. 1573-1582
    • Petrof, E.O.1    Khoruts, A.2
  • 37
    • 84877818981 scopus 로고    scopus 로고
    • Specific humoral immune response to the thomsen-friedenreich tumor antigen (CD176) in mice after vaccination with the commensal bacterium bacteroides ovatus D-6
    • Ulsemer, P. et al. Specific humoral immune response to the Thomsen-Friedenreich tumor antigen (CD176) in mice after vaccination with the commensal bacterium Bacteroides ovatus D-6. Cancer Immunol. Immunother. 62, 875-887 (2013).
    • (2013) Cancer Immunol. Immunother. , vol.62 , pp. 875-887
    • Ulsemer, P.1
  • 38
    • 34648825070 scopus 로고    scopus 로고
    • Bacteroides sp. Strain D8, the first cholesterol-reducing bacterium isolated from human feces
    • Gerard, P. et al. Bacteroides sp. strain D8, the first cholesterol-reducing bacterium isolated from human feces. Appl. Environ. Microbiol. 73, 5742-5749 (2007).
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 5742-5749
    • Gerard, P.1
  • 39
    • 84959542812 scopus 로고    scopus 로고
    • Effect of probiotics on postoperative quality of gastric bypass surgeries: A prospective randomized trial
    • Chen, J. C., Lee, W. J., Tsou, J. J., Liu, T. P. & Tsai, P. L. Effect of probiotics on postoperative quality of gastric bypass surgeries: a prospective randomized trial. Surg. Obes. Relat. Dis. 12, 57-61 (2016).
    • (2016) Surg. Obes. Relat. Dis. , vol.12 , pp. 57-61
    • Chen, J.C.1    Lee, W.J.2    Tsou, J.J.3    Liu, T.P.4    Tsai, P.L.5
  • 40
    • 0020357208 scopus 로고
    • The role of intestinal bacteria in gallstone formation in animal model. A study on biliary lipid composition and bile acid profiles in bile, small intestinal contents and feces of clostridium butyricum MIYAIRI no. 588 monocontaminated mice
    • Hosomi, M., Tanida, N. & Shimoyama, T. The role of intestinal bacteria in gallstone formation in animal model. A study on biliary lipid composition and bile acid profiles in bile, small intestinal contents and feces of clostridium butyricum MIYAIRI no. 588 monocontaminated mice. Gastroenterol. Jpn. 17, 316-323 (1982).
    • (1982) Gastroenterol. Jpn. , vol.17 , pp. 316-323
    • Hosomi, M.1    Tanida, N.2    Shimoyama, T.3
  • 41
    • 84978946147 scopus 로고    scopus 로고
    • Safety assessment of the clostridium butyricum MIYAIRI 588(R) probiotic strain including evaluation of antimicrobial sensitivity and presence of clostridium toxin genes in vitro and teratogenicity in vivo
    • Isa, K. et al. Safety assessment of the Clostridium butyricum MIYAIRI 588(R) probiotic strain including evaluation of antimicrobial sensitivity and presence of Clostridium toxin genes in vitro and teratogenicity in vivo. Hum. Exp. Toxicol. 35, 818-832 (2016).
    • (2016) Hum. Exp. Toxicol. , vol.35 , pp. 818-832
    • Isa, K.1
  • 42
    • 42149157680 scopus 로고    scopus 로고
    • Effects of active egg white Product/Clostridium butyricum MIYAIRI 588 additive on peripheral leukocyte populations in periparturient dairy cows
    • Kohiruimaki, M. et al. Effects of active egg white product/Clostridium butyricum MIYAIRI 588 additive on peripheral leukocyte populations in periparturient dairy cows. J. Vet. Med. Sci. 70, 321-323 (2008).
    • (2008) J. Vet. Med. Sci. , vol.70 , pp. 321-323
    • Kohiruimaki, M.1
  • 43
    • 0025397529 scopus 로고
    • Inhibition of enteropathogens by clostridium butyricum MIYAIRI 588
    • Kuroiwa, T., Kobari, K. & Iwanaga, M. Inhibition of enteropathogens by Clostridium butyricum MIYAIRI 588. Kansenshogaku Zasshi 64, 257-263 (1990).
    • (1990) Kansenshogaku Zasshi , vol.64 , pp. 257-263
    • Kuroiwa, T.1    Kobari, K.2    Iwanaga, M.3
  • 44
    • 0028835744 scopus 로고
    • Effects of orally administered clostridium butyricum MIYAIRI 588 on mucosal immunity in mice
    • Murayama, T. et al. Effects of orally administered Clostridium butyricum MIYAIRI 588 on mucosal immunity in mice. Vet. Immunol. Immunopathol. 48, 333-342 (1995).
    • (1995) Vet. Immunol. Immunopathol. , vol.48 , pp. 333-342
    • Murayama, T.1
  • 45
    • 77953230373 scopus 로고    scopus 로고
    • Sequence analysis of a bacteriocinogenic plasmid of clostridium butyricum and expression of the bacteriocin gene in Escherichia coli
    • Nakanishi, S. & Tanaka, M. Sequence analysis of a bacteriocinogenic plasmid of Clostridium butyricum and expression of the bacteriocin gene in Escherichia coli. Anaerobe 16, 253-257 (2010).
    • (2010) Anaerobe , vol.16 , pp. 253-257
    • Nakanishi, S.1    Tanaka, M.2
  • 46
    • 84867693196 scopus 로고    scopus 로고
    • Effect of probiotics on serum bile acids in patients with ulcerative colitis
    • Sato, S., Nagai, H. & Igarashi, Y. Effect of probiotics on serum bile acids in patients with ulcerative colitis. Hepatogastroenterology 59, 1804-1808 (2012).
    • (2012) Hepatogastroenterology , vol.59 , pp. 1804-1808
    • Sato, S.1    Nagai, H.2    Igarashi, Y.3
  • 47
    • 0242515998 scopus 로고    scopus 로고
    • Prevention of antibiotic-associated diarrhea in children by clostridium butyricum MIYAIRI
    • Seki, H. et al. Prevention of antibiotic-associated diarrhea in children by Clostridium butyricum MIYAIRI. Pediatr. Int. 45, 86-90 (2003).
    • (2003) Pediatr. Int. , vol.45 , pp. 86-90
    • Seki, H.1
  • 48
    • 84890125493 scopus 로고    scopus 로고
    • Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats
    • Seo, M. et al. Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats. Dig. Dis. Sci. 58, 3534-3544 (2013).
    • (2013) Dig. Dis. Sci. , vol.58 , pp. 3534-3544
    • Seo, M.1
  • 49
    • 2942545832 scopus 로고    scopus 로고
    • The effect of probiotic treatment with clostridium butyricum on enterohemorrhagic Escherichia coli O157:H7 infection in mice
    • Takahashi, M. et al. The effect of probiotic treatment with Clostridium butyricum on enterohemorrhagic Escherichia coli O157:H7 infection in mice. FEMS Immunol. Med. Microbiol. 41, 219-226 (2004).
    • (2004) FEMS Immunol. Med. Microbiol. , vol.41 , pp. 219-226
    • Takahashi, M.1
  • 50
    • 84922593856 scopus 로고    scopus 로고
    • Induction of peroxisomes by butyrate-producing probiotics
    • Weng, H., Endo, K., Li, J., Kito, N. & Iwai, N. Induction of peroxisomes by butyrate-producing probiotics. PLoS ONE 10, e0117851 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0117851
    • Weng, H.1    Endo, K.2    Li, J.3    Kito, N.4    Iwai, N.5
  • 51
    • 84945550161 scopus 로고    scopus 로고
    • The effect of clostridium butyricum MIYAIRI on the prevention of pouchitis and alteration of the microbiota profile in patients with ulcerative colitis
    • Yasueda, A. et al. The effect of Clostridium butyricum MIYAIRI on the prevention of pouchitis and alteration of the microbiota profile in patients with ulcerative colitis. Surg. Today 46, 939-949 (2016).
    • (2016) Surg. Today , vol.46 , pp. 939-949
    • Yasueda, A.1
  • 52
    • 84973163312 scopus 로고    scopus 로고
    • Emerging evidence of the role of gut microbiota in the development of allergic diseases
    • Simonyte Sjodin, K., Vidman, L., Ryden, P. & West, C. E. Emerging evidence of the role of gut microbiota in the development of allergic diseases. Curr. Opin. Allergy Clin. Immunol. 16, 390-395 (2016).
    • (2016) Curr. Opin. Allergy Clin. Immunol. , vol.16 , pp. 390-395
    • Simonyte Sjodin, K.1    Vidman, L.2    Ryden, P.3    West, C.E.4
  • 53
    • 84945554698 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis
    • Song, H., Yoo, Y., Hwang, J., Na, Y. C. & Kim, H. S. Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis. J. Allergy Clin. Immunol. 137, 852-860 (2016).
    • (2016) J. Allergy Clin. Immunol. , vol.137 , pp. 852-860
    • Song, H.1    Yoo, Y.2    Hwang, J.3    Na, Y.C.4    Kim, H.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.