-
1
-
-
0035289717
-
Chromosomal stability and the DNA double-stranded break connection
-
van Gent DC, Hoeijmakers JH, Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2001; 2:196-206.
-
(2001)
Nat Rev Genet
, vol.2
, pp. 196-206
-
-
Van Gent, D.C.1
Hoeijmakers, J.H.2
Kanaar, R.3
-
2
-
-
36749022214
-
The DNA damage response: Ten years after
-
Harper JW, Elledge SJ. The DNA damage response: Ten years after. Mol Cell 2007; 28:739-745.
-
(2007)
Mol Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
3
-
-
50649100744
-
Mechanism of eukaryotic homologous recombination
-
San Filippo J, Sung P, Klein H. Mechanism of eukaryotic homologous recombination. Annu Rev Biochem 2008; 77:229-257.
-
(2008)
Annu Rev Biochem
, vol.77
, pp. 229-257
-
-
San Filippo, J.1
Sung, P.2
Klein, H.3
-
5
-
-
77953229115
-
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
-
Lieber MR. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 2010; 79:181-211.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 181-211
-
-
Lieber, M.R.1
-
6
-
-
23644452672
-
The repair of DNA damages/modifications during the maturation of the immune system: Lessons from human primary immunodeficiency disorders and animal models
-
Revy P, Buck D, le Deist F, de Villartay JP. The repair of DNA damages/modifications during the maturation of the immune system: Lessons from human primary immunodeficiency disorders and animal models. Adv Immunol 2005; 87:237-295.
-
(2005)
Adv Immunol
, vol.87
, pp. 237-295
-
-
Revy, P.1
Buck, D.2
Le Deist, F.3
De Villartay, J.P.4
-
7
-
-
0035917489
-
Artemis, a novel DNA double-strand break repair/V(D) J recombination protein, is mutated in human severe combined immune deficiency
-
Moshous D, Callebaut I, de Chasseval R, et al. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 2001; 105:177-186.
-
(2001)
Cell
, vol.105
, pp. 177-186
-
-
Moshous, D.1
Callebaut, I.2
De Chasseval, R.3
-
8
-
-
18244362081
-
DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency
-
O'Driscoll M, Cerosaletti KM, Girard PM, et al. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol Cell 2001; 8:1175-1185.
-
(2001)
Mol Cell
, vol.8
, pp. 1175-1185
-
-
O'Driscoll, M.1
Cerosaletti, K.M.2
Girard, P.M.3
-
9
-
-
31044440630
-
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly
-
Buck D, Malivert L, de Chasseval P, et al. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 2006; 124:287-299.
-
(2006)
Cell
, vol.124
, pp. 287-299
-
-
Buck, D.1
Malivert, L.2
De Chasseval, P.3
-
10
-
-
0025224761
-
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, the human Ku autoantigen
-
Lees-Miller SP, Chen YR, Anderson CW. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, the human Ku autoantigen. Mol Cell Biol 1990; 10:6472-6481.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 6472-6481
-
-
Lees-Miller, S.P.1
Chen, Y.R.2
Anderson, C.W.3
-
11
-
-
0021980039
-
Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. Wt. Heat-shock protein in animal cell extracts
-
Walker AI, Hunt T, Jackson RJ, Anderson CW. Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extracts. EMBO J 1985; 4:139-145.
-
(1985)
EMBO J
, vol.4
, pp. 139-145
-
-
Walker, A.I.1
Hunt, T.2
Jackson, R.J.3
Anderson, C.W.4
-
12
-
-
0027397867
-
The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
-
Gottlieb TM, Jackson SP. The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen. Cell 1993; 72:131-142.
-
(1993)
Cell
, vol.72
, pp. 131-142
-
-
Gottlieb, T.M.1
Jackson, S.P.2
-
13
-
-
0029156599
-
DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
-
Hartley KO, Gell D, Smith GC, et al. DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 1995; 82:849-856.
-
(1995)
Cell
, vol.82
, pp. 849-856
-
-
Hartley, K.O.1
Gell, D.2
Smith, G.C.3
-
14
-
-
0028263785
-
DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA
-
Suwa A, Hirakata M, Takeda Y, Jesch SA, Mimori T, Hardin JA. DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA. Proc Natl Acad Sci USA 1994; 91:6904-6908.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 6904-6908
-
-
Suwa, A.1
Hirakata, M.2
Takeda, Y.3
Jesch, S.A.4
Mimori, T.5
Hardin, J.A.6
-
15
-
-
47249150241
-
A mechanism for DNA-PK acti-vation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining
-
Pawelczak KS, Turchi JJ. A mechanism for DNA-PK acti-vation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining. Nucleic Acids Res 2008; 36:4022-4031.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 4022-4031
-
-
Pawelczak, K.S.1
Turchi, J.J.2
-
16
-
-
74049134920
-
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex
-
Hammel M, Yu YP, Mahaney BL, et al. Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem 2010; 285:1414-1423.
-
(2010)
J Biol Chem
, vol.285
, pp. 1414-1423
-
-
Hammel, M.1
Yu, Y.P.2
Mahaney, B.L.3
-
18
-
-
84913597045
-
PIKKs-the solenoid nest where partners and kinases meet
-
Baretic D, Williams RL. PIKKs-the solenoid nest where partners and kinases meet. Curr Opin Struct Biol 2014; 29:134-142.
-
(2014)
Curr Opin Struct Biol
, vol.29
, pp. 134-142
-
-
Baretic, D.1
Williams, R.L.2
-
19
-
-
73849140503
-
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
-
Sibanda BL, Chirgadze DY, Blundell TL. Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature 2010; 463:118-121.
-
(2010)
Nature
, vol.463
, pp. 118-121
-
-
Sibanda, B.L.1
Chirgadze, D.Y.2
Blundell, T.L.3
-
20
-
-
85011345113
-
DNAPKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
-
Sibanda BL, Chirgadze DY, Ascher DB, Blundell TL. DNAPKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair. Science 2017; 355:520-524.
-
(2017)
Science
, vol.355
, pp. 520-524
-
-
Sibanda, B.L.1
Chirgadze, D.Y.2
Ascher, D.B.3
Blundell, T.L.4
-
21
-
-
0024357643
-
The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90a at two NH2-terminal threonine residues
-
Lees-Miller SP, Anderson CW. The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90a at two NH2-terminal threonine residues. J Biol Chem 1989; 264:17275-17280.
-
(1989)
J Biol Chem
, vol.264
, pp. 17275-17280
-
-
Lees-Miller, S.P.1
Anderson, C.W.2
-
22
-
-
0025037502
-
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
-
Jackson SP, MacDonald JJ, Lees-Miller S, Tjian R. GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell 1990; 63:155-165.
-
(1990)
Cell
, vol.63
, pp. 155-165
-
-
Jackson, S.P.1
MacDonald, J.J.2
Lees-Miller, S.3
Tjian, R.4
-
23
-
-
0026525775
-
DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein
-
Iijima S, Teraoka H, Date T, Tsukada K. DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein. Eur J Biochem 1992; 206:595-603.
-
(1992)
Eur J Biochem
, vol.206
, pp. 595-603
-
-
Iijima, S.1
Teraoka, H.2
Date, T.3
Tsukada, K.4
-
24
-
-
84938982424
-
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
-
Jette N, Lees-Miller SP. The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Prog Biophys Mol Biol 2015; 117:194-205.
-
(2015)
Prog Biophys Mol Biol
, vol.117
, pp. 194-205
-
-
Jette, N.1
Lees-Miller, S.P.2
-
25
-
-
84900458715
-
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
-
Davis AJ, Chen BP, Chen DJ. DNA-PK: A dynamic enzyme in a versatile DSB repair pathway. DNA Repair 2014; 17:21-29.
-
(2014)
DNA Repair
, vol.17
, pp. 21-29
-
-
Davis, A.J.1
Chen, B.P.2
Chen, D.J.3
-
26
-
-
0034662228
-
J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D) J recombination
-
Kienker LJ, Shin EK, Meek K. Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination. Nucleic Acids Res 2000; 28:2752-2761.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 2752-2761
-
-
Kienker, L.J.1
Shin, E.K.2
Meek Both V(d), K.3
-
27
-
-
65549111779
-
Essential role for DNAPKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes
-
Callen E, Jankovic M, Wong N, et al. Essential role for DNAPKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell 2009; 34:285-297.
-
(2009)
Mol Cell
, vol.34
, pp. 285-297
-
-
Callen, E.1
Jankovic, M.2
Wong, N.3
-
28
-
-
0032938747
-
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
-
Kurimasa A, Kumano S, Boubnov NV, et al. Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol Cell Biol 1999; 19:3877-3884.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3877-3884
-
-
Kurimasa, A.1
Kumano, S.2
Boubnov, N.V.3
-
29
-
-
85023179058
-
Cryo-EM structure of the DNAPK holoenzyme
-
Sharif H, Li Y, Dong Y, et al. Cryo-EM structure of the DNAPK holoenzyme. Proc Natl Acad Sci USA 2017; 114:7367-7372.
-
(2017)
Proc Natl Acad Sci USA
, vol.114
, pp. 7367-7372
-
-
Sharif, H.1
Li, Y.2
Dong, Y.3
-
30
-
-
33646714595
-
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair
-
Spagnolo L, Rivera-Calzada A, Pearl LH, Llorca O. Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. Mol Cell 2006; 22:511-519.
-
(2006)
Mol Cell
, vol.22
, pp. 511-519
-
-
Spagnolo, L.1
Rivera-Calzada, A.2
Pearl, L.H.3
Llorca, O.4
-
31
-
-
0035833552
-
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
-
Walker JR, Corpina RA, Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 2001; 412:607-614.
-
(2001)
Nature
, vol.412
, pp. 607-614
-
-
Walker, J.R.1
Corpina, R.A.2
Goldberg, J.3
-
32
-
-
85000879059
-
4.4 Å Resolution cryo-EM structure of human mTOR Complex 1
-
Yang H, Wang J, Liu M, et al. 4.4 Å Resolution cryo-EM structure of human mTOR Complex 1. Protein Cell 2016; 7:878-887.
-
(2016)
Protein Cell
, vol.7
, pp. 878-887
-
-
Yang, H.1
Wang, J.2
Liu, M.3
-
33
-
-
84877761058
-
MTOR kinase structure, mechanism and regulation
-
Yang H, Rudge DG, Koos JD, Vaidialingam B, Yang HJ, Pavletich NP. mTOR kinase structure, mechanism and regulation. Nature 2013; 497:217-223.
-
(2013)
Nature
, vol.497
, pp. 217-223
-
-
Yang, H.1
Rudge, D.G.2
Koos, J.D.3
Vaidialingam, B.4
Yang, H.J.5
Pavletich, N.P.6
-
34
-
-
0033198709
-
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
-
Gell D, Jackson SP. Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res 1999; 27:3494-3502.
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 3494-3502
-
-
Gell, D.1
Jackson, S.P.2
-
35
-
-
0032933430
-
The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit
-
Singleton BK, Torres-Arzayus MI, Rottinghaus ST, Taccioli GE, Jeggo PA. The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit. Mol Cell Biol 1999; 19:3267-3277.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3267-3277
-
-
Singleton, B.K.1
Torres-Arzayus, M.I.2
Rottinghaus, S.T.3
Taccioli, G.E.4
Jeggo, P.A.5
-
36
-
-
84929340149
-
Recognition of DNA termini by the C-terminal region of the Ku80 and the DNA-dependent protein kinase catalytic subunit
-
Woods DS, Sears CR, Turchi JJ. Recognition of DNA termini by the C-terminal region of the Ku80 and the DNA-dependent protein kinase catalytic subunit. PLoS One 2015; 10:e0127321.
-
(2015)
PLoS One
, vol.10
, pp. e0127321
-
-
Woods, D.S.1
Sears, C.R.2
Turchi, J.J.3
-
37
-
-
0348149145
-
The role of DNA dependent protein kinase in synapsis of DNA ends
-
Weterings E, Verkaik NS, Bruggenwirth HT, Hoeijmakers JHJ, van Gent DC. The role of DNA dependent protein kinase in synapsis of DNA ends. Nucleic Acids Res 2003; 31:7238-7246.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 7238-7246
-
-
Weterings, E.1
Verkaik, N.S.2
Bruggenwirth, H.T.3
Jhj, H.4
Van Gent, D.C.5
-
38
-
-
0842303305
-
The kinase activity of DNA-PK is required to protect mammalian telomeres
-
Bailey SM, Brenneman MA, Halbrook J, Nickoloff JA, Ullrich RL, Goodwin EH. The kinase activity of DNA-PK is required to protect mammalian telomeres. DNA Repair 2004; 3:225-233.
-
(2004)
DNA Repair
, vol.3
, pp. 225-233
-
-
Bailey, S.M.1
Brenneman, M.A.2
Halbrook, J.3
Nickoloff, J.A.4
Ullrich, R.L.5
Goodwin, E.H.6
-
39
-
-
84875880777
-
Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair
-
Ochi T, Gu X, Blundell TL. Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair. Structure 2013; 21:672-679.
-
(2013)
Structure
, vol.21
, pp. 672-679
-
-
Ochi, T.1
Gu, X.2
Blundell, T.L.3
-
40
-
-
84895890321
-
Sustained active site rigidity during synthesis by human DNA polymerase mu
-
Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC. Sustained active site rigidity during synthesis by human DNA polymerase mu. Nat Struct Mol Biol 2014; 21:253-260.
-
(2014)
Nat Struct Mol Biol
, vol.21
, pp. 253-260
-
-
Moon, A.F.1
Pryor, J.M.2
Ramsden, D.A.3
Kunkel, T.A.4
Bebenek, K.5
Pedersen, L.C.6
-
41
-
-
0031214080
-
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
-
Critchlow SE, Bowater RP, Jackson SP. Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr Biol 1997; 7:588-598.
-
(1997)
Curr Biol
, vol.7
, pp. 588-598
-
-
Critchlow, S.E.1
Bowater, R.P.2
Jackson, S.P.3
-
42
-
-
0030746109
-
Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic-force microscopy studies
-
Yaneva M, Kowalewski T, Lieber MR. Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic-force microscopy studies. EMBO J 1997; 16:5098-5112.
-
(1997)
EMBO J
, vol.16
, pp. 5098-5112
-
-
Yaneva, M.1
Kowalewski, T.2
Lieber, M.R.3
-
43
-
-
0242576857
-
Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs
-
Boskovic J, Rivera-Calzada A, Maman JD, et al. Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs. EMBO J 2003; 22:5875-5882.
-
(2003)
EMBO J
, vol.22
, pp. 5875-5882
-
-
Boskovic, J.1
Rivera-Calzada, A.2
Maman, J.D.3
-
44
-
-
84874914524
-
The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation
-
Davis AJ, Lee KJ, Chen DJ. The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation. J Biol Chem 2013; 288:7037-7046.
-
(2013)
J Biol Chem
, vol.288
, pp. 7037-7046
-
-
Davis, A.J.1
Lee, K.J.2
Chen, D.J.3
-
45
-
-
84860156146
-
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku
-
Meek K, Lees-Miller SP, Modesti M. N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Res 2012; 40:2964-2973.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 2964-2973
-
-
Meek, K.1
Lees-Miller, S.P.2
Modesti, M.3
-
46
-
-
77953229115
-
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
-
Lieber MR. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 2010; 79:181-211.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 181-211
-
-
Lieber, M.R.1
|