Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

Nature

Volumn 549, Issue 7673, 2017, Pages 543-547

  Smith, Zachary D ^a,b,c   Shi, Jiantao ^d,e   Gu, Hongcang ^a   Donaghey, Julie ^a,b   Clement, Kendell ^a,b,f   Cacchiarelli, Davide ^a,b   Gnirke, Andreas ^a   Michor, Franziska ^a,b,d,e   Meissner, Alexander ^a,b,g  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b Harvard University   (United States)

^c HARVARD UNIVERSITY   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^g MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; POLYCOMB GROUP PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL LINEAGE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ECTODERM; EMBRYO; EMBRYO TISSUE; EPIGENETICS; FEMALE; GERM LAYER; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MALIGNANT NEOPLASM; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PLACENTA; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; PROMOTER REGION; RNA SEQUENCING; SIGNAL TRANSDUCTION; WHOLE GENOME SEQUENCING; ANIMAL; BLASTOCYST; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; PREGNANCY;

MAMMALIA;

ANIMALS; BLASTOCYST; CELL LINEAGE; CPG ISLANDS; DNA METHYLATION; ECTODERM; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GERM LAYERS; HUMANS; MALE; MICE; NEOPLASMS; PLACENTA; PREGNANCY; PROMOTER REGIONS, GENETIC;

EID: 85032626002     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature23891     Document Type: Article

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