Potential molecular targets of ampelopsin in prevention and treatment of cancers

Anti-Cancer Agents in Medicinal Chemistry

Volumn 17, Issue 12, 2017, Pages 1610-1616

  Kou, Xianjuan ^a   Fan, Jingjing ^a   Chen, Ning ^a  

^a WUHAN SPORTS UNIVERSITY   (China)

Author keywords

Ampelopsin; Cancer; Chemotherapy; Molecular mechanism; Natural product; Signal pathway

Indexed keywords

AMPELOPSIN; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; POLYGLYCOLIC ACID; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; BREAST CANCER; CELL CYCLE ARREST; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL STRUCTURE; CHEMOTHERAPY; ENDOPLASMIC RETICULUM STRESS; HUMAN; LIVER CELL CARCINOMA; MALIGNANT NEOPLASM; MELANOMA; METASTASIS; NONHUMAN; PHYSICAL CHEMISTRY; PROSTATE CANCER; REVIEW; SIGNAL TRANSDUCTION; TUMOR INVASION; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SYNERGISM; ENDOPLASMIC RETICULUM STRESS; FLAVONOIDS; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; REACTIVE OXYGEN SPECIES;

EID: 85032008372     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871521409666170412130529     Document Type: Review

References (72)

1. Siegel, R.; Naishadham, D.; Jemal, A. Cancer statistics for Hispan-ics/Latinos. CA. Cancer J. Clin., 2012, 62(5), 283-298.
2. Wang, M.; Pan, X.; Meng, B.; Wu, Y. The effect of AMP-Na on HepG2 cell and CyclinD1 expression. Pharmacol. Clin. Chin. Materia Med., 2010, 6(6), 4.
3. Link, A.; Balaguer, F.; Goel, A. Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics. Biochem. Pharmacol., 2010, 80(12), 1771-1792.
4. Riboli, E.; Norat, T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am. J. Clin. Nutr., 2003, 78(3 Suppl), 559S-569S.
5. Ross, J.A.; Kasum, C.M. Dietary flavonoids: Bioavailability, metabolic effects and safety. Annu. Rev. Nutr., 2002, 22, 19-34.
6. Tadjalli-Mehr, K.; Becker, N.; Rahu, M.; Stengrevics, A.; Kurti-naitis, J.; Hakama, M. Randomized trial with fruits and vegetables in prevention of cancer. Acta Oncol., 2003, 42(4), 287-293.
7. Temple, N.J.; Gladwin, K.K. Fruit, vegetables, and the prevention of cancer: Research challenges. Nutrition, 2003, 19(5), 467-470.
8. Chen, C.; Kong, A.N. Dietary cancer-chemopreventive compounds: From signaling and gene expression to pharmacological effects. Trends Pharmacol. Sci., 2005, 26(6), 318-326.
9. Landis-Piwowar, K.R.; Milacic, V.; Dou, Q.P. Relationship between the methylation status of dietary flavonoids and their growth-inhibitory and apoptosis-inducing activities in human cancer cells. J. Cell Biochem., 2008, 105(2), 514-523.
10. Paluszczak, J.; Krajka-Kuzniak, V.; Baer-Dubowska, W. The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells. Toxicol. Lett., 2010, 192(2), 119-125.
11. Millimouno, F.M.; Dong, J.; Yang, L.; Li, J.; Li, X. Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Cancer Prev. Res. (Phila), 2014, 7(11), 1081-1107.
12. Kou, X.; Shen, K.; An, Y.; Qi, S.; Dai, W.X.; Yin, Z. Ampelopsin inhibits H(2)O(2)-induced apoptosis by ERK and Akt signaling pathways and up-regulation of heme oxygenase-1. Phytother. Res., 2012, 26(7), 988-994.
13. Zhang, Y.; Ning, Z.; Hu, Y. Research and utilization of ampelopsin. Chin. Trad. Patent Med., 2002, 24(12), 970-972.
14. He, G.; Pei, G.; Du, F.; Ou, Y.; Li, B. Studies on chemical constituents of Ampelopsis grossedentata. Modern Chin. Med., 2007, 9(12), 3.
15. He, G.; Pei, G.; Zhou, T.; Zhou, X. Determination of total flavonoids and dihydromyricetin in Ampelopsis grossedentata (Hand-mazz) W.T. Wang. J. Chin. Materia Med., 2000, 25(7), 4.
16. Wang, M.; Pan, X.; Meng, B.; Wu, Y. The effect of AMP-Na on HepG2 cell and cyclin D1 expression. Pharmacol. Clin. Chin. Materia Med., 2010, 26(6), 4.
17. Wu, X.; Ni, F. Synthesis and characterization of Cl-PGA-AMP ester. Strait. Pharmaceut. J., 2012, 24(11), 4.
18. Zhang, Y.S.; Xiao, G.S.; Chen, W.D. The synthesis of liposoluble dihydromyricetin (LDMY) and its antioxidation characteristic. Nat. Prod. Res. Dev., 2006, 18(2), 3.
19. Jiao, X.; Liu, F.; Liu, H. The synethesis of the complex of dihydromyricetin with zinc and research on the effect of antitumor in vitro. Asia-Pacific Tradit. Med., 2009, 5(11), 3.
20. Wu, X.; Ni, F. Synthesis and characterization of Cl-PGA-AMP ester. Strait Pharmacy, 2012, 24(11), 4.
21. Marelli, L.; Stigliano, R.; Triantos, C.; Senzolo, M.; Cholongitas, E.; Davies, N.; Tibballs, J.; Meyer, T.; Patch, D.W.; Burroughs, A.K. Transarterial therapy for hepatocellular carcinoma: Which technique is more effective? A systematic review of cohort and randomized studies. Cardio. Intervent. Radiol., 2007, 30(1), 6-25.
22. Zhang, Q.; Liu, D. Ampelopsin induces apoptosis via altering expression of Bcl-2/Bax and activating caspase-3 in human hepatoma cell line Bel-7402. Chin. Pharmacol. Bulletin, 2009, 25(11), 1502-1506.
23. Zheng, Z.; Yan, L. Experimental study of vine tea dihydromyricetin on liver cancer H22. Chin. Arch. Trad. Chinese Med., 2006, 24(9), 1627-1629.
24. Qi, S.; Kou, X.; Lv, J.; Qi, Z.; Yan, L. Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK. Environ. Toxicol. Pharmacol., 2015, 40(3), 847-854.
25. Baek, S.H.; Ko, J.H.; Lee, H.; Jung, J.; Kong, M.; Lee, J.W.; Lee, J.; Chinnathambi, A.; Zayed, M.E.; Alharbi, S.A.; Lee, S.G.; Shim, B.S.; Sethi, G.; Kim, S.H.; Yang, W.M.; Um, J.Y.; Ahn, K.S. Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells. Phytomedicine, 2016, 23(5), 566-577.
26. Ge, Y.; Wang, Y.; Pang, L.; Zhang, L.; Zhai, Y.; Zhou, H. Proliferation, apoptosis and invasion effects of mistletoe alkali on human osteosarcoma U2OS in vitro. Int. Surg., 2016. [Epub ahead of print].
27. Podhorecka, M.; Macheta, A.; Bozko, M.; Bozko, A.; Malek, N.P.; Bozko, P. Deregulation of apoptosis - is it still an important issue in pathogenesis of chronic lymphocytic leukemia? Curr. Cancer Drug Targ., 2016. [Epub ahead of print].
28. De Araujo Junior, R.F.; de Souza, T.P.; Pires, J.G.; Soares, L.A.; de Araujo, A.A.; Petrovick, P.R.; Macedo, H.D.; A dry extract of Phyllanthus niruri protects normal cells and induces apoptosis in human liver carcinoma cells. Exp. Biol. Med. (Maywood), 2012, 237(11), 1281-1288.
29. Yang, G.; Chang, B.; Yang, F.; Guo, X.; Cai, K.Q.; Xiao, X.S.; Wang, H.; Sen, S.; Hung, M.C.; Mills, G.B.; Chang, S.; Multani, A.S.; Mercado-Uribe, I.; Liu, J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin. Cancer Res., 2010, 16(12), 3171-3181.
30. Khan, M.; Yu, B.; Rasul, A.; Al Shawi, A.; Yi, F.; Yang, H.; Ma, T. Jaceosidin induces apoptosis in U87 glioblastoma cells through G2/M phase arrest. Evid. Based Complement. Alternat. Med., 2012, 2012, 703034.
31. Khan, M.; Zheng, B.; Yi, F.; Rasul, A.; Gu, Z.; Li, T.; Gao, H.; Qazi, J.I.; Yang, H.; Ma, T. Pseudolaric acid B induces caspase-dependent and caspase-independent apoptosis in u87 glioblastoma cells. Evid. Based Complement Alternat. Med., 2012, 2012, 957568.
32. Yang, Z.; Guo, J.; Pan, J.; Li, G. The effect of anti-tumor, antioxidation, liver and blood lipid pharmacological research on ampelopsis. Traditional Chin. Med. Res., 2004, 17(4), 57-60.
33. Ni, F.; Yao, X.; Guo, D.; Lin, J.; Zhou, C.; Chen, X. The impact of ampelopsin on human prostate cancer PC3 cell proliferation and apoptosis. Pharmacol. Clin., 2012, 28(3), 39-41.
34. Grivennikov, S.I.; Greten, F.R.; Karin, M. Immunity, inflammation, and cancer. Cell, 2010, 140(6), 883-899.
35. Aita, G.; Da Costa, W.H.; De Cassio Zequi, S.; Da Cunha, I.W.; Soares, F.; Guimaraes, G.C.; Lopes, A. Pattern of invasion is the most important prognostic factor in patients with penile cancer submitted to lymph node dissection and pathological absence of lymph node metastasis. BJU Int., 2015, 116(4), 584-589.
36. Hu, B.; Zhang, K.; Li, S.; Li, H.; Yan, Z.; Huang, L.; Wu, J.; Han, X.; Jiang, W.; Mulatibieke, T.; Zheng, L.; Wan, R.; Wang, X.; Hu, G. HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic cancer. Cancer Lett., 2016. [Epub ahead of print].
37. Yan, W.J.; Ma, X.C.; Gao, X.Y.; Xue, X.H.; Zhang, S.Q. Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis. Mol. Clin. Oncol., 2016, 4(4), 472-476.
38. Liu, D.Y.; Zheng, H.Q.; Luo, G.Q. Effects of ampelopsin on invasion and metastasis of B16 mouse melanoma in vivo and in vitro. Chin. J. Chin. Materia Med., 2003, 28(10), 957-962.
39. Liu, Y.; Xie, S.; Wang, Y.; Luo, K.; Wang, Y.; Cai, Y. Liquiriti-genin inhibits tumor growth and vascularization in a mouse model of HeLa cells. Molecules, 2012, 17(6), 7206-7216.
40. Zhou, Q.; Yan, B.; Hu, X.; Li, X.B.; Zhang, J.; Fang, J. Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin. Mol. Cancer Ther., 2009, 8(6), 1684-1691.
41. Ni, F.; Gong, Y.; Li, L.; Abdolmaleky, H.M.; Zhou, J.R. Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice. PLoS One, 2012, 7(6), e38802.
42. Luo, G.Q.; Zeng, S.; Liu, D.Y. Inhibitory effects of ampelopsin on angiogenesis. J. Chin. Med. Materials, 2006, 29(2), 146-150.
43. Laplante, M.; Sabatini, D.M. mTOR signaling in growth control and disease. Cell, 2012, 149(2), 274-293.
44. Polak, P.; Hall, M.N. mTOR and the control of whole body metabolism. Curr. Opin. Cell Biol., 2009, 21(2), 209-218.
45. Strimpakos, A.S.; Karapanagiotou, E.M.; Saif, M.W.; Syrigos, K.N. The role of mTOR in the management of solid tumors: An overview. Cancer Treat. Rev., 2009, 35(2), 148-159.
46. Zhou, H.; Luo, Y.; Huang, S. Updates of mTOR inhibitors. Anticancer Agents Med. Chem., 2010, 10(7), 571-581.
47. Li, Y.; Luo, S.; Dong, W.; Song, X.; Zhou, H.; Zhao, L.; Jia, L. Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1. Lab. Invest., 2016, 96(7), 731-740.
48. Wang, X.; Cheng, K.; Han, Y.; Zhang, G.; Dong, J.; Cui, Y.; Yang, Z. Effects of psoralen as an anti-tumor agent in human breast cancer MCF-7/ADR cells. Biol. Pharm. Bull., 2016, 39(5), 815-822.
49. Ohtani, H.; Ikegawa, T.; Honda, Y.; Kohyama, N.; Morimoto, S.; Shoyama, Y.; Juichi, M.; Naito, M.; Tsuruo, T.; Sawada, Y. Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. Pharm. Res., 2007, 24(10), 1936-1943.
50. Ye, J.T.; Zheng, Y.; Liu, D.Y. Reversal effect and its mechanism of ampelopsin on multidrug resistance in K562/ADR cells Chin. J. Chin. Materia Med., 2009, 34(6), 761-765.
51. Zhang, Y.; Wu, Y.; Li, W. Experimental study on apoptosis induced by ampelopsin sodium combined with carboplatin on human lung adenocarcinoma cell line GLC-82. Pharmacol. Clin., 2014, 30(4), 26-29.
52. Pan, X.; Wang, M.; Wu, Y.; Zhang, H. Experimental study on enhancement of radiotherapy sensitivity of hepatocellular carcinoma cells by ampelopsin-sodium. J. Chin. Med. Materials, 2013, 36(2), 5.
53. Zhou, W.M.; He, R.R.; Ye, J.T.; Zhang, N.; Liu, D.Y. Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives. Molecules, 2010, 15(4), 2114-2123.
54. Wargasetia, T.L.; Shahib, N.; Martaadisoebrata, D.; Dhianawaty, D.; Hernowo, B. Characterization of apoptosis and autophagy through Bcl-2 and Beclin-1 immunoexpression in gestational tro-phoblastic disease. Iran J. Reprod. Med., 2015, 13(7), 413-420.
55. Zhang, S.; Niu, Q.; Gao, H.; Ma, R.; Lei, R.; Zhang, C.; Xia, T.; Li, P.; Xu, C.; Wang, C.; Chen, J.; Dong, L.; Zhao, Q.; Wang, A. Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride. Environ. Pollut., 2016, 212, 97-104.
56. Klionsky, D.J.; Emr, S.D. Autophagy as a regulated pathway of cellular degradation. Science, 2000, 290(5497), 1717-1721.
57. Levine, B.; Kroemer, G. Autophagy in the pathogenesis of disease. Cell, 2008, 132(1), 27-42.
58. Chen, N.; Karantza, V. Autophagy as a therapeutic target in cancer. Cancer Biol. Ther., 2011, 11(2), 157-168.
59. Chen, N.; Karantza-Wadsworth, V. Role and regulation of autophagy in cancer. Biochim. Biophys. Acta, 2009, 1793(9), 1516-1523.
60. Opipari, A.W.J.R.; Tan, L.; Boitano, A.E.; Sorenson, D.R.; Aurora, A.; Liu, J.R. Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res., 2004, 64(2), 696-703.
61. Zhang, S.F.; Wang, X.L.; Yang, X.Q.; Chen, N. Autophagy-associated targeting pathways of natural products during cancer treatment. Asi. Pac. J. Cancer Prev., 2014, 15(24), 10557-10563.
62. Wang, N.; Feng, Y. Elaborating the role of natural products-induced autophagy in cancer treatment: Achievements and artifacts in the state of the art. Biomed. Res. Int., 2015, 2015, 934207.
63. Bartel, D.P. MicroRNAs: Target recognition and regulatory functions. Cell, 2009, 136(2), 215-233.
64. Calin, G.A.; Croce, C.M. MicroRNA signatures in human cancers. Nat. Rev. Cancer, 2006, 6(11), 857-866.
65. Chan, J.A.; Krichevsky, A.M.; Kosik, K.S. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res., 2005, 65(14), 6029-6033.
66. Chen, Q.; Yang, L.; Xiao, Y.; Zhu, J.; Li, Z. Circulating mi-croRNA-182 in plasma and its potential diagnostic and prognostic value for pancreatic cancer. Med. Oncol., 2014, 31(11), 225.
67. Tuomarila, M.; Luostari, K.; Soini, Y.; Kataja, V.; Kosma, V.M.; Mannermaa, A. Overexpression of microRNA-200c predicts poor outcome in patients with PR-negative breast cancer. PLoS One, 2014, 9(10), e109508.
68. Wang, K.Y.; Ma, J.; Zhang, F.X.; Yu, M.J.; Xue, J.S.; Zhao, J.S. MicroRNA-378 inhibits cell growth and enhances L-OHP-induced apoptosis in human colorectal cancer. IUBMB Life, 2014, 66(9), 645-654.
69. Zhang, W.; Wang, Y.E.; Zhang, Y.; Leleu, X.; Reagan, M.; Zhang, Y.; Mishima, Y.; Glavey, S.; Manier, S.; Sacco, A.; Jiang, B.; Roc-caro, A.M.; Ghobrial, I.M. Global epigenetic regulation of microRNAs in multiple myeloma. PLoS One, 2014, 9(10), e110973.
70. Li, Y.; Kong, D.; Wang, Z.; Sarkar, F.H. Regulation of microRNAs by natural agents: An emerging field in chemoprevention and chemotherapy research. Pharm. Res., 2010, 27(6), 1027-1041.
71. Sun, M.; Estrov, Z.; Ji, Y.; Coombes, K.R.; Harris, D.H.; Kurzrock, R. Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol. Cancer Ther., 2008, 7(3), 464-473.
72. Li, Y.; VandenBoom, T.G., 2nd; Kong, D.; Wang, Z.; Ali, S.; Philip, P.A.; Sarkar, F.H. Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res., 2009, 69(16), 6704-6712.