Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Ni, Feng ^a,b   Gong, Yi ^b   Li, Linglin ^b   Abdolmaleky, Hamid M ^b   Zhou, Jin Rong ^b  

^a Fujian Health College   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPELOPSIN; BETA ACTIN; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 2; CHEMOKINE RECEPTOR CXCR4; CYCLIN B1; CYCLIN DEPENDENT KINASE 2; FLAVONOID; MYRICETIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG POTENCY; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; LUNG METASTASIS; LYMPH NODE METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; TUMOR VASCULARIZATION; TUMOR VOLUME; ANIMAL; CELL MOTION; DRUG EFFECT; GENETICS; METABOLISM; PROSTATE TUMOR; TUMOR CELL LINE;

ANIMALIA; MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FLAVONOIDS; HUMANS; LYMPHATIC METASTASIS; MALE; MICE; PROSTATIC NEOPLASMS; RECEPTORS, CXCR4;

EID: 84861897760     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038802     Document Type: Article

References (35)

1. Siegel R, Naishadham D, Jemal A, (2012) Cancer statistics, 2012. CA: a cancer journal for clinicians 62: 10-29.
2. Zhong ZX, Qin JP, Zhou GF, Chen XF, (2002) [Experimental studies of hypoglycemic action on total flavone of Ampelopsis grossedentata from Guangxi]. Zhongguo Zhong Yao Za Zhi 27: 687-689.
3. He G, Du F, Yang W, Pei G, Zhu Y, (2003) [Effects of tengcha flavonoids on scavenging oxygen free radicals and inhibiting lipid-peroxidation]. Zhong Yao Cai 26: 338-340.
4. Murakami T, Miyakoshi M, Araho D, Mizutani K, Kambara T, et al. (2004) Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin. Biofactors 21: 175-178.
5. Hase K, Ohsugi M, Xiong Q, Basnet P, Kadota S, et al. (1997) Hepatoprotective effect of Hovenia dulcis THUNB. on experimental liver injuries induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide. Biol Pharm Bull 20: 381-385.
6. Zeng S, Luo GQ, Liu DY, (2006) [The chemotaxis effect of ampelopsin on the immunocytes]. Zhong Yao Cai 29: 260-262.
7. Liu D, Luo M, (2001) [Study on inhibitory effect of ampelopsin on melanoma by serologic pharmacological method]. Zhong Yao Cai 24: 348-350.
8. Liu DY, Zheng HQ, Luo GQ, (2003) [Effects of ampelopsin on invasion and metastasis of B16 mouse melanoma in vivo and in vitro]. Zhongguo Zhong Yao Za Zhi 28: 957-961.
9. Zheng HQ, Liu DY, (2003) [Anti-invasive and anti-metastatic effect of ampelopsin on melanoma]. Ai Zheng 22: 363-367.
10. Zeng S, Liu D, Ye Y, Wang L, Wang W, (2004) [Anti-tumor effects of ampelopsin on human lung cancer GLC-82 implanted in nude mice]. Zhong Yao Cai 27: 842-845.
11. Luo GQ, Zeng S, Liu DY, (2006) [Inhibitory effects of ampelopsin on angiogenesis]. Zhong Yao Cai 29: 146-150.
12. Ye J, Zheng Y, Liu D, (2009) [Reversal effect and its mechanism of ampelopsin on multidrug resistance in K562/ADR cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 34: 761-765.
13. Perez de Castro I, de Carcer G, Montoya G, Malumbres M, (2008) Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr Opin Pharmacol 8: 375-383.
14. Krajewska M, Krajewski S, Epstein JI, Shabaik A, Sauvageot J, et al. (1996) Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers. American Journal of Pathology 148: 1567-1576.
15. Raffo AJ, Perlman H, Chen MW, Day ML, Streitman JS, et al. (1995) Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo. Cancer Research 55: 4438-4445.
16. McConkey DJ, Greene G, Pettaway CA, (1996) Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line. Cancer Research 56: 5594-5599.
17. Song R, Harris LD, Pettaway CA, (2010) Downmodulation of Bcl-2 sensitizes metastatic LNCaP-LN3 cells to undergo apoptosis via the intrinsic pathway. Prostate 70: 571-583.
18. Folkman J, (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Medicine 1: 27-31.
19. Cao Y, (2010) Angiogenesis: What can it offer for future medicine? Exp Cell Res 316: 1304-1308.
20. Salvucci O, Bouchard A, Baccarelli A, Deschenes J, Sauter G, et al. (2006) The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study. Breast Cancer Res Treat 97: 275-283.
21. Yang L, Jackson E, Woerner BM, Perry A, Piwnica-Worms D, et al. (2007) Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res 67: 651-658.
22. Harvey JR, Mellor P, Eldaly H, Lennard TW, Kirby JA, et al. (2007) Inhibition of CXCR4-mediated breast cancer metastasis: a potential role for heparinoids? Clin Cancer Res 13: 1562-1570.
23. Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, et al. (2003) A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A 100: 13513-13518.
24. Scotton CJ, Wilson JL, Milliken D, Stamp G, Balkwill FR, (2001) Epithelial cancer cell migration: a role for chemokine receptors? Cancer Res 61: 4961-4965.
25. Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, et al. (2002) Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 62: 5930-5938.
26. Muller A, Homey B, Soto H, Ge N, Catron D, et al. (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56.
27. Liu DY, Ye JT, Yang WH, Yan J, Zeng CH, et al. (2004) Ampelopsin, a small molecule inhibitor of HIV-1 infection targeting HIV entry. Biomed Environ Sci 17: 153-164.
28. Grande F, Garofalo A, Neamati N, (2008) Small molecules anti-HIV therapeutics targeting CXCR4. Curr Pharm Des 14: 385-404.
29. Singh AV, Franke AA, Blackburn GL, Zhou JR, (2006) Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis. Cancer Res 66: 1851-1858.
30. Zhou J-R, Mukherjee P, Gugger ET, Tanaka T, Blackburn GL, et al. (1998) The inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis. Cancer Res 58: 5231-5238.
31. Zhou J-R, Yu L, Zerbini LF, Libermann TA, Blackburn GL, (2004) Progression to androgen-independent LNCaP human prostate tumors: cellular and molecular alterations. Int J Cancer 81: 800-806.
32. NIH OLAW, (2002) Institutional Animal Care and Use Committee Guidebook. In: Pitts M, editors. 2nd ed.
33. Zhou J-R, Gugger ET, Tanaka T, Guo Y, Blackburn GL, et al. (1999) Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr 129: 1628-1635.
34. Zhou J-R, Yu L, Zhong Y, Nassr RL, Franke AA, et al. (2002) Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean components. The Prostate 53: 143-153.
35. Steel RGD, Torrie JH, (1980) Principles and Procedures of Statistics: A Biometrical Approach. New York McGraw-Hill book Company, Inc.