A dry extract of Phyllanthus niruri protects normal cells and induces apoptosis in human liver carcinoma cells

Experimental Biology and Medicine

Volumn 237, Issue 11, 2012, Pages 1281-1288

  de Araújo Júnior, Raimundo Fernandes ^a   de Souza, Tatiane Pereira ^b   Pires, Júlia Glória Lucatelli ^c   Soares, Luiz Alberto Lira ^d   de Araújo, Aurigena Antunes ^a   Petrovick, Pedro Ros ^e   Mâcedo, Helainy Daline Oliveira ^a   Oliveira, Ana Luiza Cabral de Sá Leitão ^a   Guerra, Gerlane Coelho Bernardo ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^b FEDERAL UNIVERSITY OF AMAZONAS   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d FederalUniversityofPernambuco ^*  (Brazil)

^e Federal do Rio Grande do Sul   (Brazil)

Author keywords

Apoptosis; Caspase 3; Hepatocellular carcinoma; Phyllanthus niruri

Indexed keywords

CASPASE 3; PHYLLANTHUS NIRURI EXTRACT;

ANALYSIS OF VARIANCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KERATINOCYTE; LIVER CELL CARCINOMA; PHYLLANTHUS NIRURI;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; HEP G2 CELLS; HT29 CELLS; HUMANS; LIVER NEOPLASMS; PHYLLANTHUS; PILOT PROJECTS; PLANT EXTRACTS;

EUPHORBIACEAE; PHYLLANTHUS NIRURI;

EID: 84871201637     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2012.012130     Document Type: Article

References (24)

1. Barros ME, Schor N, Boim MA. Effects of an aqueous extract from Phyllantus niruri on calcium oxalate crystallization in vitro. Urol Res 2003;30:374-9
2. Bhattacharjee R, Sil PC. The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytother Res 2006;20:595-601
3. Allen PD, Bustin SA, Newland AC. The role of apoptosis (programmed cell death) in haemopoiesis and the immune system. Blood Rev 1993;7:63-73
4. Fulda S. Modulation of apoptosis by natural products for cancer therapy. Planta Med 2010;76:1075-9
5. Freitas AM, Schor N, Boim MA. The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation. BJU Int 2002;89:829-34
6. Sripanidkulchai B, Tattawasart U, Laupatarakasem P, Vinitketkumneun U, Sripanidkulchai K, Furihata C, Matsushima T. Antimutagenic and anticarcinogenic effects of Phyllanthus amarus. Phytomedicine 2002;9:26-32
7. Rajeshkumar NV, Joy KL, Kuttan G, Ramsewak RS, Nair MG, Kuttan R. Antitumour and anticarcinogenic activity of Phyllanthus amarus extract. J Ethnopharmacol 2002;81:17-22
8. Harish R, Shivanandappa T. Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chem 2006;95:180-5
9. Sarkar MK, Sil PC. Hepatocytes are protected by herb Phyllanthus niruri protein isolate against thioacetamide toxicity. Pathophysiology 2007;14:113-20
10. De Souza T, Gómez-Amoza JL, Matínez-Pacheco R, Petrovick PR. Compression behavior of formulations from Phyllantus niruri spray dried extract. Pharmazie 2006;61:213-7
11. Soares LAL, Bassani VL, González Ortega G, Petrovick PR. Total flavonoid determination for the quality control of aqueous extractives from Phyllanthus niruri L. Acta Farm Bonaer 2003;22:18
12. Gong J, Traganos F, Darzynkiewicz Z. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal Biochem 1994;218:314-9
13. Huang ST, Yang RC, Pang JHS. Aqueous extract of Phyllanthus urinaria induces apoptosis in human cancer cells. Am J Chinese Med 2004;32:175-83
14. Tan X, Hu D, Li S, Han Y, Zhang Y, Zhou D. Differences of four catechins in cell cycle arrest and induction of apoptosis in LoVo cells. Cancer Lett 2000;158:1-6
15. Saeki K, Sano M, Miyase T, Nakamura Y, Hara Y, Aoyagi Y, Ysemura M. Apoptosis-inducing activity of polyphenol compounds derived from tea catechins in human histiolytic lymphoma U937 cells. Biosci Biotechnol Biochem 1999;63:585-7
16. O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007;445:106-10
17. Kolenko V, Uzzo RG, Bukowski R, Bander NH, Novick AC, Hsi ED, Finke JH. Dead or dying: necrosis versus apoptosis in caspase-deficient human renal cell carcinoma. Cancer Res 1999;59:2838-42
18. Huang ST, Yang RC, Yang LH, Lee PN, Pang JHS. Phyllanthus urinaria triggers the apoptosis and Bcl-2 down-regulation in Lewis lung carcinoma cells. Life Sci 2003;72:1705-16
19. Tang YQ, Jaganath IB, Sekaran SD. Phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis. PloS One 2010;5:e12644
20. Persad R, Liu C, Wu TT, Houlihan PS, Hamilton SR, Diehl AM, Rashib A. Overexpression of caspase-3 in hepatocellular carcinomas. Mod Pathol 2004;17:861-7
21. Ohno Y, Fukuda K, Takemura G, Toyota M, Watanabe M, Yasuda N, Xinbin Q, Maruyama R, Akao S, Gotou K, Fujiwara T, Fujiwara H. Induction of apoptosis by gallic acid in lung cancer cells. Anti-Cancer Drug 1999;10:845-51
22. Kawada M, Ohno Y, Ri Y, Ikoma T, Yuugetu H, Asai T, Watanabe M, Yasuba N, Akao S, Takemura G, Minatoguchi S, Gotok K, Fujiwara H, Fukuda K. Anti-tumor effect of gallic acid on LL-2 lung cancer cells transplanted in mice. Anti-Cancer Drug 2001;12:847-52
23. Ji BC, Hsu WH, Yang JS, Hsia TC, Lu CC, Chiang JH, Yang JL, Lin CH, Lin JJ, Suen LJ, Gibson Wood W, Chung JG. Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo. J Agric Food Chem 2009;57:7596-604
24. Sharma P, Parmar J, Verma P, Sharma P, Goyal PK. Anti-tumor activity of Phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asian Pac J Cancer P 2009;10:1089-94