In-silico-driven metabolic engineering of Pseudomonas putida for enhanced production of poly-hydroxyalkanoates

Metabolic Engineering

Volumn 15, Issue 1, 2013, Pages 113-123

  Poblete Castro, Ignacio ^a,b   Binger, Danielle ^a   Rodrigues, Andre ^c   Becker, Judith ^c   Martins Dos Santos, Vitor A P ^a,d   Wittmann, Christoph ^c  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b UNIVERSIDAD TECNOLÓGICA METROPOLITANA   (Chile)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Bio polymer; Elementary flux modes; Glucose dehydrogenase; In silico design; Pathway engineering; Phosphogluconolactonase; Polyhydroxyalkanoates; Pseudomonas putida KT2440; Systems metabolic engineering; Transcriptome

Indexed keywords

ELEMENTARY FLUX MODES; GLUCOSE DEHYDROGENASE; IN-SILICO; PHOSPHOGLUCONOLACTONASE; POLYHYDROXYALKANOATES; PSEUDOMONAS PUTIDA; TRANSCRIPTOMES;

BIOCHEMISTRY; GENE EXPRESSION; GLUCOSE; PHYSIOLOGICAL MODELS;

METABOLIC ENGINEERING;

6 PHOSPHOGLUCONOLACTONASE; GLUCONOLACTONASE; GLUCOSE; GLUCOSE DEHYDROGENASE; POLYHYDROXYALKANOIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BATCH FERMENTATION; BATCH REACTOR; BIOMASS PRODUCTION; COMPUTER MODEL; CONTROLLED STUDY; CULTURE MEDIUM; GENE DELETION; GENE EXPRESSION PROFILING; GENE TARGETING; GROWTH RATE; METABOLIC ENGINEERING; MUTANT; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS PUTIDA; SYNTHESIS; WILD TYPE;

COMPUTER SIMULATION; GENETIC ENHANCEMENT; GLUCOSE; METABOLIC ENGINEERING; MODELS, BIOLOGICAL; POLYHYDROXYALKANOATES; PSEUDOMONAS PUTIDA;

PSEUDOMONAS PUTIDA;

EID: 84871463200     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2012.10.004     Document Type: Article

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