Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance

Journal of Endocrinology

Volumn 235, Issue 3, 2017, Pages 179-191

  Wada, Tsutomu ^a   Ishikawa, Akari ^a   Watanabe, Eri ^a   Nakamura, Yuto ^a   Aruga, Yusuke ^a   Hasegawa, Hayate ^a   Onogi, Yasuhiro ^a   Honda, Hiroe ^a,b   Nagai, Yoshinori ^a,c   Takatsu, Kiyoshi ^a,b   Ishii, Yoko ^a   Sasahara, Masakiyo ^a   Koya, Daisuke ^d   Tsuneki, Hiroshi ^a   Sasaoka, Toshiyasu ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b Toyama Prefectural Institute for Pharmaceutical Research   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Glucose metabolism; Mineralocorticoid receptor; NLRP3 inflammasome, adipose tissue macrophage; Renin angiotensin system

Indexed keywords

ADENOSINE TRIPHOSPHATE; ATM PROTEIN; CRYOPYRIN; EPLERENONE; GLUCOSE; GLYCOPROTEIN P 15095; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INSULIN; INTERLEUKIN 1BETA; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; NIGERICIN; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL; CYTOKINE; MINERALOCORTICOID ANTAGONIST; NLRP3 PROTEIN, MOUSE; SPIRONOLACTONE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY FAT; BODY WEIGHT GAIN; BONE MARROW DERIVED MACROPHAGE; CASPASE1 GENE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE RELEASE; DIET INDUCED OBESITY; DRUG MECHANISM; ENERGY METABOLISM; EPIDIDYMIS; GENE; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; IL6 GENE; IN VITRO STUDY; INGUINAL WHITE ADIPOSE TISSUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; INTRA-ABDOMINAL FAT; LIPID STORAGE; LIVER HISTOLOGY; MACROPHAGE; MALE; MOUSE; NLRP3 GENE; NONHUMAN; PRIORITY JOURNAL; PROIL1B GENE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT; TNFA GENE; WHITE ADIPOSE TISSUE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; COMPLICATION; DRUG EFFECTS; INFLAMMATION; LIPID DIET; LIVER; METABOLISM; OBESITY; PATHOLOGY; PRECLINICAL STUDY;

ADIPOSE TISSUE, WHITE; ANIMALS; CYTOKINES; DIET, HIGH-FAT; DRUG EVALUATION, PRECLINICAL; ENERGY METABOLISM; GLUCOSE INTOLERANCE; INFLAMMASOMES; INFLAMMATION; LIVER; MACROPHAGES; MALE; MICE, INBRED C57BL; MINERALOCORTICOID RECEPTOR ANTAGONISTS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; OBESITY; REACTIVE OXYGEN SPECIES; RECEPTORS, MINERALOCORTICOID; SPIRONOLACTONE;

EID: 85031684286     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-17-0351     Document Type: Article

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