Adipocyte mineralocorticoid receptor activation leads to metabolic syndrome and induction of prostaglandin D2 synthase

Hypertension

Volumn 66, Issue 1, 2015, Pages 149-157

  Urbanet, Riccardo ^a,b   Cat, Aurelie Nguyen Dinh ^c   Feraco, Alessandra ^a,d   Venteclef, Nicolas ^a   El Mogrhabi, Soumaya ^a   Sierra Ramos, Catalina ⁱ   De La Rosa, Diego Alvarez ^e   Adler, Gail K ^f   Quilliot, Didier ^g   Rossignol, Patrick ^g,h   Fallo, Francesco ^b   Touyz, Rhian M ^c   Jaisser, Frédéric ^a,g,h  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d IRCCS SAN RAFFAELE PISANA   (Italy)

^e UNIVERSIDAD DE LA LAGUNA   (Spain)

^f HARVARD MEDICAL SCHOOL   (United States)

^g UNIVERSITY HOSPITAL OF NANCY   (France)

^h UNIVERSITÉ DE LORRAINE   (France)

ⁱ CHU de Nancy ^*

Author keywords

aldosterone; obesity; prostaglandin D2 synthase 21kDa, brain; spironolactone

Indexed keywords

ALDOSTERONE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PROSTAGLANDIN D2; PROSTAGLANDIN D2 SYNTHASE; PROSTAGLANDIN SYNTHASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-(4-(2H-TETRAZOL-5-YL)BUTYL)PIPERIDINE; DIBENZO[A,D]CYCLOHEPTENE DERIVATIVE; ISOMERASE; LEPTIN RECEPTOR; LEPTIN RECEPTOR, MOUSE; LIPOCALIN; MINERALOCORTICOID ANTAGONIST; PIPERIDINE DERIVATIVE; PROSTAGLANDIN R2 D-ISOMERASE; SPIRONOLACTONE;

ADIPOCYTE; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL HYPERPLASIA; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FAT MASS; GENE TARGETING; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN RESPONSE; INSULINEMIA; INTRAABDOMINAL FAT; METABOLIC SYNDROME X; MORBID OBESITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBCUTANEOUS FAT; SYSTOLIC BLOOD PRESSURE; TRANSCRIPTION INITIATION SITE; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; 3T3 CELL LINE; ANIMAL; BIOSYNTHESIS; DEFICIENCY; DRUG EFFECTS; ENZYME INDUCTION; GENETICS; MALE; METABOLISM; MOUSE MUTANT; OBESITY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE; TUMOR CELL LINE; WHITE ADIPOCYTE;

3T3-L1 CELLS; ADIPOCYTES, WHITE; ALDOSTERONE; ANIMALS; CELL LINE, TUMOR; DIBENZOCYCLOHEPTENES; ENZYME INDUCTION; HUMANS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; MALE; METABOLIC SYNDROME X; MICE; MICE, OBESE; MICE, TRANSGENIC; MINERALOCORTICOID RECEPTOR ANTAGONISTS; OBESITY; PIPERIDINES; RECEPTORS, LEPTIN; RECEPTORS, MINERALOCORTICOID; RNA, MESSENGER; SPIRONOLACTONE; SUBCUTANEOUS FAT; UP-REGULATION;

EID: 84940048286     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.04981     Document Type: Article

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