Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice

FASEB Journal

Volumn 29, Issue 9, 2015, Pages 3899-3910

  Kadoya, Hiroyuki ^a   Satoh, Minoru ^a   Sasaki, Tamaki ^a   Taniguchi, ShuN'Ichiro ^b   Takahashi, Masafumi ^c   Kashihara, Naoki ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

^b SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Chronic inflammation; Kidney; Mineralocorticoid receptor; Mitochondria; Reactive oxygen species

Indexed keywords

ALDOSTERONE; APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN WITH CASPASE RECRUITMENT DOMAIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; EPLERENONE; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; IL1B PROTEIN, MOUSE; PYCARD PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CELL CULTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPERIMENTAL RENAL FIBROSIS; INTERSTITIAL NEPHRITIS; KIDNEY FIBROSIS; KIDNEY INTERSTITIUM; KIDNEY TUBULE DISORDER; MACROPHAGE ACTIVATION; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENAL TUBULOINTERSTITIAL INFLAMMATION; SUPERNATANT; WILD TYPE; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYME ACTIVATION; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; KIDNEY DISEASE; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ALDOSTERONE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CASPASE 1; ENZYME ACTIVATION; FIBROSIS; GENE EXPRESSION REGULATION; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; KIDNEY DISEASES; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84952718555     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-271734     Document Type: Article

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