Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet

American Journal of Physiology - Endocrinology and Metabolism

Volumn 305, Issue 11, 2013, Pages

  Wada, Tsutomu ^a   Miyashita, Yusuke ^a   Sasaki, Motohiro ^a   Aruga, Yusuke ^a   Nakamura, Yuto ^a   Ishii, Yoko ^a   Sasahara, Masakiyo ^a   Kanasaki, Keizo ^b   Kitada, Munehiro ^b   Koya, Daisuke ^b   Shimano, Hitoshi ^c   Tsuneki, Hiroshi ^a   Sasaoka, Toshiyasu ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Eplerenone; Inflammation; Kupffer cells; Nonalcoholic steatohepatitis; Sterol response element binding protein 1c; Transgenic

Indexed keywords

ADIPONECTIN; ALANINE AMINOTRANSFERASE; ALDOSTERONE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; COLLAGEN; CORTICOSTERONE; EPLERENONE; FRUCTOSE; GLUCOSE; INSULIN; LEPTIN; LIPOPOLYSACCHARIDE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; BONE MARROW CELL; CELL INFILTRATION; CELL SIZE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DYSLIPIDEMIA; ENERGY EXPENDITURE; EPIDIDYMIS FAT; EXPERIMENTAL MODEL; GENE OVEREXPRESSION; GENOTYPE; GLUCONEOGENESIS; GLUCOSE INTOLERANCE; HEPATITIS; HISTOPATHOLOGY; HYPERTROPHY; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; KUPFFER CELL; LIPID DIET; LIPID LIVER LEVEL; LIPID STORAGE; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER PROTECTION; MACROPHAGE; MALE; METABOLIC SYNDROME X; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUGAR INTAKE; TRANSGENIC MOUSE; WILD TYPE;

EPLERENONE; INFLAMMATION; KUPFFER CELLS; NONALCOHOLIC STEATOHEPATITIS; STEROL RESPONSE ELEMENT-BINDING PROTEIN-1C; TRANSGENIC;

ANIMALS; CELLS, CULTURED; DIET, HIGH-FAT; DIETARY CARBOHYDRATES; FATTY LIVER; FRUCTOSE; LIVER; MALE; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MINERALOCORTICOID RECEPTOR ANTAGONISTS; PHENOTYPE; RATS; RATS, WISTAR; SPIRONOLACTONE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84888875158     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00419.2013     Document Type: Article

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