메뉴 건너뛰기




Volumn 77, Issue 20, 2017, Pages 5591-5601

Monocarboxylate transporter MCT1 promotes tumor metastasis independently of its activity as a lactate transporter

Author keywords

[No Author keywords available]

Indexed keywords

CD147 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 1; TRANSCRIPTION FACTOR RELA; COTRANSPORTER; MONOCARBOXYLATE TRANSPORT PROTEIN 1; MONOCARBOXYLATE TRANSPORTER;

EID: 85031399951     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-17-0764     Document Type: Article
Times cited : (101)

References (50)
  • 3
    • 84867112200 scopus 로고    scopus 로고
    • Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay
    • Fiaschi T, Marini A, Giannoni E, Taddei ML, Gandellini P, De Donatis A, et al. Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. Cancer Res 2012; 72:5130–40.
    • (2012) Cancer Res , vol.72 , pp. 5130-5140
    • Fiaschi, T.1    Marini, A.2    Giannoni, E.3    Taddei, M.L.4    Gandellini, P.5    De Donatis, A.6
  • 4
    • 84863397848 scopus 로고    scopus 로고
    • The monocarboxylate transporter family–role and regulation
    • Halestrap AP, Wilson MC. The monocarboxylate transporter family–role and regulation. IUBMB Life 2012;64:109–19.
    • (2012) IUBMB Life , vol.64 , pp. 109-119
    • Halestrap, A.P.1    Wilson, M.C.2
  • 6
    • 0034663601 scopus 로고    scopus 로고
    • The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
    • Dimmer KS, Friedrich B, Lang F, Deitmer JW, Broer S. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J 2000;350(Pt 1):219–27.
    • (2000) Biochem J , vol.350 , pp. 219-227
    • Dimmer, K.S.1    Friedrich, B.2    Lang, F.3    Deitmer, J.W.4    Broer, S.5
  • 7
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    • Ullah MS, Davies AJ, Halestrap AP. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 2006;281:9030–7.
    • (2006) J Biol Chem , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 8
    • 3242798360 scopus 로고    scopus 로고
    • Lactate in solid malignant tumors: Potential basis of a metabolic classification in clinical oncology
    • Walenta S, Schroeder T, Mueller-Klieser W. Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology. Curr Med Chem 2004;11:2195–204.
    • (2004) Curr Med Chem , vol.11 , pp. 2195-2204
    • Walenta, S.1    Schroeder, T.2    Mueller-Klieser, W.3
  • 9
    • 80053640489 scopus 로고    scopus 로고
    • CD147 subunit of lactate/Hþ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
    • Le Floch R, Chiche J, Marchiq I, Naiken T, Ilk K, Murray CM, et al. CD147 subunit of lactate/Hþ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A 2011;108:16663–8.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 16663-16668
    • Le Floch, R.1    Chiche, J.2    Marchiq, I.3    Naiken, T.4    Ilk, K.5    Murray, C.M.6
  • 10
    • 84896701206 scopus 로고    scopus 로고
    • Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer
    • Polanski R, Hodgkinson CL, Fusi A, Nonaka D, Priest L, Kelly P, et al. Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer. Clin Cancer Res 2014;20:926–37.
    • (2014) Clin Cancer Res , vol.20 , pp. 926-937
    • Polanski, R.1    Hodgkinson, C.L.2    Fusi, A.3    Nonaka, D.4    Priest, L.5    Kelly, P.6
  • 12
    • 84979950555 scopus 로고    scopus 로고
    • Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas
    • Miranda-Goncalves V, Granja S, Martinho O, Honavar M, Pojo M, Costa BM, et al. Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas. Oncotarget 2016;7:46335–53.
    • (2016) Oncotarget , vol.7 , pp. 46335-46353
    • Miranda-Goncalves, V.1    Granja, S.2    Martinho, O.3    Honavar, M.4    Pojo, M.5    Costa, B.M.6
  • 14
    • 84857716739 scopus 로고    scopus 로고
    • Multiple biological activities of lactic acid in cancer: Influences on tumor growth, angiogenesis and metastasis
    • Dhup S, Dadhich RK, Porporato PE, Sonveaux P. Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. Curr Pharm Des 2012;18:1319–30.
    • (2012) Curr Pharm Des , vol.18 , pp. 1319-1330
    • Dhup, S.1    Dadhich, R.K.2    Porporato, P.E.3    Sonveaux, P.4
  • 15
    • 0031029634 scopus 로고    scopus 로고
    • Correlation of high lactate levels in head and neck tumors with incidence of metastasis
    • Walenta S, Salameh A, Lyng H, Evensen JF, Mitze M, Rofstad EK, et al. Correlation of high lactate levels in head and neck tumors with incidence of metastasis. Am J Pathol 1997;150:409–15.
    • (1997) Am J Pathol , vol.150 , pp. 409-415
    • Walenta, S.1    Salameh, A.2    Lyng, H.3    Evensen, J.F.4    Mitze, M.5    Rofstad, E.K.6
  • 17
    • 0028784650 scopus 로고
    • Correlation of high lactate levels in human cervical cancer with incidence of metastasis
    • Schwickert G, Walenta S, Sundfor K, Rofstad EK, Mueller-Klieser W. Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res 1995;55:4757–9.
    • (1995) Cancer Res , vol.55 , pp. 4757-4759
    • Schwickert, G.1    Walenta, S.2    Sundfor, K.3    Rofstad, E.K.4    Mueller-Klieser, W.5
  • 18
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, Rofstad EK, et al. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 2000;60:916–21.
    • (2000) Cancer Res , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfor, K.5    Rofstad, E.K.6
  • 19
    • 22844442936 scopus 로고    scopus 로고
    • Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: The ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)
    • Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem 2005;280:27213–21.
    • (2005) J Biol Chem , vol.280 , pp. 27213-27221
    • Wilson, M.C.1    Meredith, D.2    Fox, J.E.3    Manoharan, C.4    Davies, A.J.5    Halestrap, A.P.6
  • 20
    • 84860760655 scopus 로고    scopus 로고
    • CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemo-sensitivity in pancreatic cancer cells
    • Pan Y, He B, Song G, Bao Q, Tang Z, Tian F, et al. CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemo-sensitivity in pancreatic cancer cells. Oncol Rep 2012;27:2003–9.
    • (2012) Oncol Rep , vol.27 , pp. 2003-2009
    • Pan, Y.1    He, B.2    Song, G.3    Bao, Q.4    Tang, Z.5    Tian, F.6
  • 21
    • 84905402353 scopus 로고    scopus 로고
    • Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration
    • De Saedeleer CJ, Porporato PE, Copetti T, Perez-Escuredo J, Payen VL, Brisson L, et al. Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration. Oncogene 2014;33:4060–8.
    • (2014) Oncogene , vol.33 , pp. 4060-4068
    • De Saedeleer, C.J.1    Porporato, P.E.2    Copetti, T.3    Perez-Escuredo, J.4    Payen, V.L.5    Brisson, L.6
  • 22
    • 79954603194 scopus 로고    scopus 로고
    • Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells
    • Izumi H, Takahashi M, Uramoto H, Nakayama Y, Oyama T, Wang KY, et al. Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells. Cancer Sci 2011;102:1007–13.
    • (2011) Cancer Sci , vol.102 , pp. 1007-1013
    • Izumi, H.1    Takahashi, M.2    Uramoto, H.3    Nakayama, Y.4    Oyama, T.5    Wang, K.Y.6
  • 23
    • 84954350066 scopus 로고    scopus 로고
    • Monocarboxylate transporters MCT1 and MCT4 regulate migration and invasion of pancreatic ductal adenocarcinoma cells
    • Kong SC, Nohr-Nielsen A, Zeeberg K, Reshkin SJ, Hoffmann EK, Novak I, et al. Monocarboxylate transporters MCT1 and MCT4 regulate migration and invasion of pancreatic ductal adenocarcinoma cells. Pancreas 2016; 45:1036–47.
    • (2016) Pancreas , vol.45 , pp. 1036-1047
    • Kong, S.C.1    Nohr-Nielsen, A.2    Zeeberg, K.3    Reshkin, S.J.4    Hoffmann, E.K.5    Novak, I.6
  • 24
    • 84973577774 scopus 로고    scopus 로고
    • Monocarboxylate transporter 1 contributes to growth factor-induced tumor cell migration independent of transporter activity
    • Gray AL, Coleman DT, Shi R, Cardelli JA. Monocarboxylate transporter 1 contributes to growth factor-induced tumor cell migration independent of transporter activity. Oncotarget 2016;7:32695–706.
    • (2016) Oncotarget , vol.7 , pp. 32695-32706
    • Gray, A.L.1    Coleman, D.T.2    Shi, R.3    Cardelli, J.A.4
  • 27
    • 85017538868 scopus 로고    scopus 로고
    • Radiosynthesis and validation of (þ/-)-[18F]-3-fluoro-2-hydroxypropio-nate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors
    • Van Hee VF, Labar D, Dehon G, Grasso D, Gregoire V, Muccioli GG, et al. Radiosynthesis and validation of (þ/-)-[18F]-3-fluoro-2-hydroxypropio-nate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. Oncotarget 2017;8:24415–28.
    • (2017) Oncotarget , vol.8 , pp. 24415-24428
    • Van Hee, V.F.1    Labar, D.2    Dehon, G.3    Grasso, D.4    Gregoire, V.5    Muccioli, G.G.6
  • 28
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
    • Halestrap AP, Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 1999;343(Pt 2):281–99.
    • (1999) Biochem J , vol.343 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 29
    • 84875183640 scopus 로고    scopus 로고
    • The SLC16 gene family - Structure, role and regulation in health and disease
    • Halestrap AP. The SLC16 gene family - structure, role and regulation in health and disease. Mol Aspects Med 2013;34:337–49.
    • (2013) Mol Aspects Med , vol.34 , pp. 337-349
    • Halestrap, A.P.1
  • 31
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    • Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 1998;280:1614–7.
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1    Gu, J.2    Matsumoto, K.3    Aota, S.4    Parsons, R.5    Yamada, K.M.6
  • 32
    • 67649763451 scopus 로고    scopus 로고
    • Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells
    • Gillet L, Roger S, Besson P, Lecaille F, Gore J, Bougnoux P, et al. Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J Biol Chem 2009;284:8680–91.
    • (2009) J Biol Chem , vol.284 , pp. 8680-8691
    • Gillet, L.1    Roger, S.2    Besson, P.3    Lecaille, F.4    Gore, J.5    Bougnoux, P.6
  • 35
    • 84949521347 scopus 로고    scopus 로고
    • Metabolic changes associated with tumor metastasis, part 1: Tumor pH, glycolysis and the pentose phosphate pathway
    • Payen VL, Porporato PE, Baselet B, Sonveaux P. Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway. Cell Mol Life Sci 2016;73:1333–48.
    • (2016) Cell Mol Life Sci , vol.73 , pp. 1333-1348
    • Payen, V.L.1    Porporato, P.E.2    Baselet, B.3    Sonveaux, P.4
  • 36
    • 84887607569 scopus 로고    scopus 로고
    • Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-kappaB pathway
    • Zhao Z, Wu MS, Zou C, Tang Q, Lu J, Liu D, et al. Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-kappaB pathway. Cancer Lett 2014;342:150–8.
    • (2014) Cancer Lett , vol.342 , pp. 150-158
    • Zhao, Z.1    Wu, M.S.2    Zou, C.3    Tang, Q.4    Lu, J.5    Liu, D.6
  • 37
    • 0037449711 scopus 로고    scopus 로고
    • BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice
    • Burke JR, Pattoli MA, Gregor KR, Brassil PJ, MacMaster JF, McIntyre KW, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 2003;278:1450–6.
    • (2003) J Biol Chem , vol.278 , pp. 1450-1456
    • Burke, J.R.1    Pattoli, M.A.2    Gregor, K.R.3    Brassil, P.J.4    MacMaster, J.F.5    McIntyre, K.W.6
  • 38
    • 4344688679 scopus 로고    scopus 로고
    • A fluorescent orthotopic model of metastatic cervical carcinoma
    • Cairns RA, Hill RP. A fluorescent orthotopic model of metastatic cervical carcinoma. Clin Exp Metastasis 2004;21:275–81.
    • (2004) Clin Exp Metastasis , vol.21 , pp. 275-281
    • Cairns, R.A.1    Hill, R.P.2
  • 39
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • Aslakson CJ, Miller FR. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 1992;52:1399–405.
    • (1992) Cancer Res , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 40
    • 0028605480 scopus 로고
    • The kinetics, substrate and inhibitor specificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF
    • Carpenter L, Halestrap AP. The kinetics, substrate and inhibitor specificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF. Biochem J 1994;304(Pt 3):751–60.
    • (1994) Biochem J , vol.304 , pp. 751-760
    • Carpenter, L.1    Halestrap, A.P.2
  • 42
    • 79960320020 scopus 로고    scopus 로고
    • Lysyl oxidase-like-1 enhances lung metastasis when lactate accumulation and monocarboxylate transporter expression are involved
    • Lee GH, Kim DS, Chung MJ, Chae SW, Kim HR, Chae HJ. Lysyl oxidase-like-1 enhances lung metastasis when lactate accumulation and monocarboxylate transporter expression are involved. Oncol Lett 2011;2:831–8.
    • (2011) Oncol Lett , vol.2 , pp. 831-838
    • Lee, G.H.1    Kim, D.S.2    Chung, M.J.3    Chae, S.W.4    Kim, H.R.5    Chae, H.J.6
  • 44
    • 0027388949 scopus 로고
    • Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity
    • Newell K, Franchi A, Pouyssegur J, Tannock I. Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity. Proc Natl Acad Sci U S A 1993;90:1127–31.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 1127-1131
    • Newell, K.1    Franchi, A.2    Pouyssegur, J.3    Tannock, I.4
  • 45
    • 28844503376 scopus 로고    scopus 로고
    • Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase
    • Becker HM, Hirnet D, Fecher-Trost C, Sultemeyer D, Deitmer JW. Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase. J Biol Chem 2005;280:39882–9.
    • (2005) J Biol Chem , vol.280 , pp. 39882-39889
    • Becker, H.M.1    Hirnet, D.2    Fecher-Trost, C.3    Sultemeyer, D.4    Deitmer, J.W.5
  • 46
    • 60549091044 scopus 로고    scopus 로고
    • Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells
    • Slomiany MG, Grass GD, Robertson AD, Yang XY, Maria BL, Beeson C, et al. Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells. Cancer Res 2009;69:1293–301.
    • (2009) Cancer Res , vol.69 , pp. 1293-1301
    • Slomiany, M.G.1    Grass, G.D.2    Robertson, A.D.3    Yang, X.Y.4    Maria, B.L.5    Beeson, C.6
  • 47
    • 84922788145 scopus 로고    scopus 로고
    • Analysis of the binding moiety mediating the interaction between monocarboxylate transporters and carbonic anhydrase II
    • Noor SI, Dietz S, Heidtmann H, Boone CD, McKenna R, Deitmer JW, et al. Analysis of the binding moiety mediating the interaction between monocarboxylate transporters and carbonic anhydrase II. J Biol Chem 2015; 290:4476–86.
    • (2015) J Biol Chem , vol.290 , pp. 4476-4486
    • Noor, S.I.1    Dietz, S.2    Heidtmann, H.3    Boone, C.D.4    McKenna, R.5    Deitmer, J.W.6
  • 48
    • 75149178349 scopus 로고    scopus 로고
    • Tumor metabolism of lactate: The influence and therapeutic potential for MCT and CD147 regulation
    • Kennedy KM, Dewhirst MW. Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. Future Oncol 2010;6:127–48.
    • (2010) Future Oncol , vol.6 , pp. 127-148
    • Kennedy, K.M.1    Dewhirst, M.W.2
  • 49
    • 77956176871 scopus 로고    scopus 로고
    • EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-depen-dent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling
    • Venkatesan B, Valente AJ, Prabhu SD, Shanmugam P, Delafontaine P, Chandrasekar B. EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-depen-dent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling. J Mol Cell Cardiol 2010;49:655–63.
    • (2010) J Mol Cell Cardiol , vol.49 , pp. 655-663
    • Venkatesan, B.1    Valente, A.J.2    Prabhu, S.D.3    Shanmugam, P.4    Delafontaine, P.5    Chandrasekar, B.6
  • 50
    • 84953638182 scopus 로고    scopus 로고
    • CD147 promotes IKK/IkappaB/ NF-kappaB pathway to resist TNF-induced apoptosis in rheumatoid arthritis synovial fibroblasts
    • Berl
    • Zhai Y, Wu B, Li J, Yao XY, Zhu P, Chen ZN. CD147 promotes IKK/IkappaB/ NF-kappaB pathway to resist TNF-induced apoptosis in rheumatoid arthritis synovial fibroblasts. J Mol Med (Berl) 2016;94:71–82.
    • (2016) J Mol Med , vol.94 , pp. 71-82
    • Zhai, Y.1    Wu, B.2    Li, J.3    Yao, X.Y.4    Zhu, P.5    Chen, Z.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.