cGAS is activated by DNA in a length-dependent manner

EMBO Reports

Volumn 18, Issue 10, 2017, Pages 1707-1715

  Luecke, Stefanie ^a   Holleufer, Andreas ^a   Christensen, Maria H ^a   Jønsson, Kasper L ^a   Boni, Gerardo A ^a   Sørensen, Lambert K ^b   Johannsen, Mogens ^b   Jakobsen, Martin R ^a   Hartmann, Rune ^a   Paludan, Søren R ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

cGAS; DNA sensing; interferon; length dependence; STING

Indexed keywords

CYCLIC GMP AMP SYNTHASE; DOUBLE STRANDED DNA; INTERFERON; RECOMBINANT ENZYME; SYNTHETASE; UNCLASSIFIED DRUG; DNA; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE;

ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL LINE; CHEMISTRY; CYTOSOL; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM;

CELL LINE; CYTOSOL; DNA; ENZYME ACTIVATION; HUMANS; IMMUNITY, INNATE; INTERFERON TYPE I; MEMBRANE PROTEINS; NUCLEOTIDYLTRANSFERASES; SIGNAL TRANSDUCTION;

EID: 85030171403     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201744017     Document Type: Article

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