SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans

Nature Medicine

Volumn 23, Issue 8, 2017, Pages 975-983

  Allen, E Kaitlynn ^a   Randolph, Adrienne G ^b   Bhangale, Tushar ^c   Dogra, Pranay ^a   Ohlson, Maikke ^c   Oshansky, Christine M ^a,f   Zamora, Anthony E ^a   Shannon, John P ^a   Finkelstein, David ^a   Dressen, Amy ^c   DeVincenzo, John ^d,e   Caniza, Miguela ^a   Youngblood, Ben ^a   Rosenberger, Carrie M ^c   Thomas, Paul G ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c GENENTECH INC   (United States)

^d UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^e LE BONHEUR CHILDREN S HOSPITAL   (United States)

^f U S DEPARTMENT OF HEALTH AND HUMAN SERVICES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR CTCF; CCCTC-BINDING FACTOR; IFITM3 PROTEIN, HUMAN; INTERFERON REGULATORY FACTOR 3; IRF3 PROTEIN, HUMAN; MEMBRANE PROTEIN; REPRESSOR PROTEIN; RNA BINDING PROTEIN;

5' UNTRANSLATED REGION; ADOLESCENT; ADULT; AGED; AIRWAY; ALLELE; ARTICLE; BINDING ASSAY; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHILD; COHORT ANALYSIS; DISEASE SEVERITY; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; IFITM3 GENE; INFECTION RISK; INFLUENZA; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MUCOSAL IMMUNITY; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; QUANTITATIVE TRAIT LOCUS; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION; CYTOLOGY; DNA METHYLATION; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; METABOLISM; NASAL LAVAGE FLUID; SEVERITY OF ILLNESS INDEX; WESTERN BLOTTING;

ALLELES; BLOTTING, WESTERN; CD8-POSITIVE T-LYMPHOCYTES; DNA METHYLATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFLUENZA, HUMAN; INTERFERON REGULATORY FACTOR-3; MEMBRANE PROTEINS; NASAL LAVAGE FLUID; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; QUANTITATIVE TRAIT LOCI; REPRESSOR PROTEINS; RNA-BINDING PROTEINS; SEVERITY OF ILLNESS INDEX;

EID: 85029295000     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4370     Document Type: Article

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