IFITM3 and severe influenza virus infection. No evidence of genetic association

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 35, Issue 11, 2016, Pages 1811-1817

  Lopez Rodriguez M ^a,b   Herrera Ramos, E ^a,b   Sole Violan J ^a   Ruiz Hernandez J J ^a   Borderias L ^c   Horcajada, J P ^d,e   Lerma Chippirraz, E ^d   Rajas, O ^f   Briones, M ^g   Perez Gonzalez M C ^a   Garcia Bello M A ^a   Lopez Granados E ^h   Rodriguez de Castro, F ^a,b   Rodriguez Gallego C ⁱ  

^a HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^b UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^c HOSPITAL SAN JORGE   (Spain)

^d HOSPITAL DEL MAR   (Spain)

^e INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^f HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^g UNIVERSITY OF VALENCIA   (Spain)

^h HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

ⁱ HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON INDUCED TRANSMEMBRANE PROTEIN 3; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; IFITM3 PROTEIN, HUMAN; RNA BINDING PROTEIN;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CAUCASIAN; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC PROCEDURES; HOMOZYGOTE; HUMAN; INFLUENZA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUROLOGIC DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SANGER SEQUENCING; AGED; DNA SEQUENCE; GENETIC PREDISPOSITION; GENETICS; GENOTYPING TECHNIQUE; SPAIN; YOUNG ADULT;

ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPING TECHNIQUES; HUMANS; INFLUENZA, HUMAN; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RNA-BINDING PROTEINS; SEQUENCE ANALYSIS, DNA; SPAIN; YOUNG ADULT;

EID: 84982893713     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-016-2732-7     Document Type: Article

References (14)

1. Bautista E, Chotpitayasunondh T, Gao Z, Harper SA, Shaw M, Uyeki TM et al (2010) Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med 362(18):1708–1719. doi:10.1056/NEJMra1000449
2. Broberg E, Nicoll A, Amato-Gauci A (2011) Seroprevalence to influenza A (H1N1) 2009 virus–where are we? Clin Vaccine Immunol 18:1205–1212. doi:10.1128/CVI.05072-11
3. Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, Anderson LJ, Fukuda K (2003) Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 289:179–186
4. Hayward AC, Fragaszy EB, Bermingham A, Wang L, Copas A, Edmunds WJ et al (2014) Comparative community burden and severity of seasonal and pandemic influenza: results of the Flu Watch cohort study. Lancet Respir Med 2(6):445–454. doi:10.1016/S2213-2600(14)70034-7
5. Albright FS, Orlando P, Pavia AT, Jackson GG, Cannon Albright LA (2008) Evidence for a heritable predisposition to death due to influenza. J Infect Dis 197:18–24. doi:10.1086/524064
6. Horby P, Nguyen NY, Dunstan SJ, Baillie JK (2013) An updated systematic review of the role of host genetics in susceptibility to influenza. Influenza Other Respir Viruses (Suppl 2):37–41. doi:10.1111/irv.12079
7. Keynan Y, Malik S, Fowke KR (2013) The role of polymorphisms in host immune genes in determining the severity of respiratory illness caused by pandemic H1N1 influenza. Public Health Genomics 16(1–2):9–16. doi:10.1159/000345937
8. Herrera-Ramos E, López-Rodríguez M, Ruíz-Hernández JJ, Horcajada JP, Borderías L, Lerma E et al (2014) Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection. Crit Care 18(3):R127. doi:10.1186/cc13934
9. Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE et al (2012) IFITM3 restricts the morbidity and mortality associated with influenza. Nature 484(7395):519–523. doi:10.1038/nature10921
10. Williams DE, Wu WL, Grotefend CR, Radic V, Chung C, Chung YH et al (2014) IFITM3 polymorphism rs12252-C restricts influenza A viruses. PLoS One 9(10):e110096. doi:10.1371/journal.pone.0110096
11. Bailey CC, Huang IC, Kam C, Farzan M (2012) Ifitm3 limits the severity of acute influenza in mice. PLoS Pathog 8(9):e1002909. doi:10.1371/journal.ppat.1002909
12. Zhang YH, Zhao Y, Li N, Peng YC, Giannoulatou E, Jin RH et al (2013) Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun 4:1418. doi:10.1038/ncomms2433
13. Wang Z, Zhang A, Wan Y, Liu X, Qiu C, Xi X et al (2014) Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection. Proc Natl Acad Sci USA 111(2):769–774. doi:10.1073/pnas.1321748111
14. Mills TC, Rautanen A, Elliott KS, Parks T, Naranbhai V, Ieven MM et al (2014) IFITM3 and susceptibility to respiratory viral infections in the community. J Infect Dis 209(7):1028–1031. doi:10.1093/infdis/jit468