Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity

EMBO Reports

Volumn 17, Issue 11, 2016, Pages 1657-1671

  Compton, Alex A ^a   Roy, Nicolas ^a   Porrot, Françoise ^a   Billet, Anne ^a   Casartelli, Nicoletta ^a   Yount, Jacob S ^b   Liang, Chen ^c   Schwartz, Olivier ^a,d,e  

^a INSTITUT PASTEUR   (France)

^b OHIO STATE UNIVERSITY   (United States)

^c MCGILL UNIVERSITY   (Canada)

^d CNRS   (France)

^e Vaccine Research Institute   (France)

Author keywords

evolution; HIV; IFITM; innate immunity; virus

Indexed keywords

ENVELOPE PROTEIN; GAG PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; INTERFERON INDUCED TRANSMEMBRANE PROTEIN; PROTEIN; TYROSINE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; IFITM3 PROTEIN, HUMAN; INTERFERON INDUCING AGENT; MEMBRANE PROTEIN; RNA BINDING PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENDOCYTOSIS; FEMALE; GENE DUPLICATION; GENE LOCUS; GENE MUTATION; GENETIC REGULATION; GENOME ANALYSIS; HOST CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INFLUENZA A VIRUS; MULTIGENE FAMILY; NONHUMAN; PRIMATE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; TRANSLATION REGULATION; UBIQUITINATION; VIRION; ANIMAL; CELL LINE; GENETICS; GENOME; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INNATE IMMUNITY; MOLECULAR EVOLUTION; MUTATION; PHYSIOLOGY; PROTEIN TRANSPORT; VIRUS;

ANIMALS; CELL LINE; EVOLUTION, MOLECULAR; GENOME; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INTERFERON INDUCERS; MEMBRANE PROTEINS; MUTATION; PRIMATES; PROTEIN TRANSPORT; RNA-BINDING PROTEINS; UBIQUITINATION; VIRUSES;

EID: 84985930520     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201642771     Document Type: Article

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