Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 2, 2014, Pages 769-774

  Wang, Zhongfang ^a,b   Zhang, Anli ^a   Wan, Yanmin ^a   Liu, Xinian ^a   Qiu, Chao ^a   Xi, Xiuhong ^a   Ren, Yanqin ^a   Wang, Jing ^a   Dong, Yuan ^a   Bao, Meijuan ^a   Li, Liangzhu ^a   Zhou, Mingzhe ^a   Yuan, Songhua ^a   Sun, Jun ^a   Zhu, Zhaoqin ^a   Chen, Liang ^a   Li, Qingsheng ^c   Zhang, Zhiyong ^a   Zhang, Xiaoyan ^a,d   Lu, Shuihua ^a   Doherty, Peter C ^b,e   Kedzierska, Katherine ^b   Xu, Jianqing ^a,d   more..

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF NEBRASKA   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^e ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Avian influenza; Clinical outcome

Indexed keywords

CHEMOKINE; GAMMA INTERFERON; INTERFERON INDUCED TRANSMEMBRANE PROTEIN 3; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MEMBRANE PROTEIN; METHYLPREDNISOLONE; OSELTAMIVIR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIVIRAL THERAPY; ARTICLE; CLINICAL ARTICLE; CYTOKINE RELEASE; CYTOKINE STORM; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENOTYPE; HISTOLOGY; HOSPITAL ADMISSION; HUMAN; HUMAN TISSUE; INFLAMMATION; INFLAMMATORY INFILTRATE; INFLUENZA A; INFLUENZA VIRUS A H7N9; LUNG LAVAGE; MACROPHAGE; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PATIENT MONITORING; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL; VERY ELDERLY; VIRUS REPLICATION;

AVIAN INFLUENZA; CLINICAL OUTCOME;

BASE SEQUENCE; CHINA; CYTOKINES; DISEASE OUTBREAKS; DNA PRIMERS; GENOTYPE; HISTORY, 21ST CENTURY; HUMANS; INFLUENZA A VIRUS, H7N9 SUBTYPE; INFLUENZA, HUMAN; LUNG; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RNA-BINDING PROTEINS; SEQUENCE ANALYSIS, DNA; STATISTICS, NONPARAMETRIC;

EID: 84892584163     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321748111     Document Type: Article

References (20)

1. Wen Y, Klenk H-D (2013) H7N9 avian influenza virus?Search and re-search. Emerging Microbes Infect 2:e18.
2. Gao R, et al. (2013) Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 368(20):1888-1897.
3. Li Q, et al. (2013) Preliminary Report: Epidemiology of the Avian Influenza A (H7N9) Outbreak in China. N Engl J Med, 10.1056/NEJMoa1304617.
4. Yang F, et al. (2013) A fatal case caused by novel H7N9 avian influenza A virus in China. Emerging Microbes and Infections, 10.1038/emi.2013.22.
5. Chen Y, et al. (2013) Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: Clinical analysis and characterisation of viral genome. Lancet 381(9881):1916-1925.
6. Gao HN, et al. (2013) Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med 368(24):2277-2285.
7. Yu H, et al. (2013) Human infection with avian influenza A H7N9 virus: An assessment of clinical severity. Lancet 382(9887):138-145.
8. Zhou J, et al. (2013) Biological features of novel avian influenza A (H7N9) virus. Nature 499(7459):500-503.
9. Brass AL, et al. (2009) The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 139(7):1243-1254.
10. Feeley EM, et al. (2011) IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog 7(10):e1002337.
11. Everitt AR, et al.; GenISIS Investigators; MOSAIC Investigators (2012) IFITM3 restricts the morbidity and mortality associated with influenza. Nature 484(7395):519-523.
12. Jia R, et al. (2012) The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization. J Virol 86(24):13697-13707.
13. Zhang YH, et al. (2013) Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun 4:1418.
14. de Jong MD, et al. (2006) Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med 12(10):1203-1207.
15. Kohlmeier JE, Woodland DL (2009) Immunity to respiratory viruses. Annu Rev Immunol 27:61-82.
16. Tamura S, Kurata T (2004) Defense mechanisms against influenza virus infection in the respiratory tract mucosa. Jpn J Infect Dis 57(6):236-247.
17. Maines TR, et al. (2008) Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response. Immunol Rev 225:68-84.
18. Fritz RS, et al. (1999) Nasal cytokine and chemokine responses in experimental influenza A virus infection: Results of a placebo-controlled trial of intravenous zanamivir treatment. J Infect Dis 180(3):586-593.
19. Baggiolini M, Walz A, Kunkel SL (1989) Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest 84(4):1045-1049.
20. Driscoll KE (1994) Macrophage inflammatory proteins: Biology and role in pulmonary inflammation. Exp Lung Res 20(6):473-490.