On the role of IRF in host defense

Journal of Interferon and Cytokine Research

Volumn 22, Issue 1, 2002, Pages 59-71

  Barnes, Betsy ^a   Lubyova, Barbora ^a   Pitha, Paula M ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; HISTONE ACETYLTRANSFERASE; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 7; ISOPROTEIN; SERINE; TRANS ACTING FACTOR; UNCLASSIFIED DRUG;

CELL NUCLEUS; CELLULAR DISTRIBUTION; GENE ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC CODE; HERPES VIRUS; HOST RESISTANCE; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ACETYLTRANSFERASES; AMINO ACID SEQUENCE; DNA-BINDING PROTEINS; HERPESVIRUS 8, HUMAN; HISTONE ACETYLTRANSFERASES; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTOR-7; INTERFERON REGULATORY FACTORS; INTERFERON-ALPHA; INTERFERON-BETA; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; VIRUS DISEASES;

HERPESVIRIDAE;

EID: 0036181161     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999002753452665     Document Type: Review

References (96)

1. Humoral immunity due to long-lived plasma cells
2. Transcriptional activation: A complex puzzle with few easy pieces
3. IRF family of transcription factors as regulators of host defense
4. Biochemistry of interferons and their actions
5. The interferon genes
6. Interferons and their actions
7. Positive and negative control of human interferon-β gene expression
8. Lymphocyte responses and cytokines
9. Interferon-gamma: Biology and role in pathogenesis
10. The IFN gamma receptor: A paradigm for cytokine receptor signaling
11. Type I interferon as a powerful adjuvant for monocyte-derived den-dritic cell development and activityin vitro and in Hu-PBL-SCID mice
12. Human Th1 and Th2 subsets: Doubt no more
13. Functional diversity of helper T lymphocytes
14. +T cells
15. +T cells
16. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potentials by Th1 or Th2 human T cell clones
17. Type I interferons and T helper development
18. The nature of the principal type 1 interferon-producing cells in human blood
19. Type I interferons keep activated T cells alive
20. Interferons alpha and beta as immune regulators - A new look
21. The human type I interferon gene cluster
22. Induction of interferon alpha genes expression
23. The mechanism of transcriptional synergy of an in vitro assembled interferon-β enhanceosome
24. Recruitment of CBP/p300 by the IFNβ enhanceosome is required for synergistic activation of transcription
25. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo
26. Differential and cell type specific expression on murine β-interferon genes is regulated on the transcriptional level
27. Reconstitution of virus-mediated expression of interferon alpha genes in human fi-broblast cells by ectopic interferon regulatory factor-7
28. Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7
29. Virus-mediated induction of interferon A gene requires cooperation between multiple binding factors in the interferon a promoter region
30. Silencer activity in the interferon A gene promoter
31. Recruitment of multiple in-terferon regulatory factors and histone acetyltransferase to the tran-scriptionally active IFNA promoters
32. Repression of virus-induced inter-feron A promoters by homeodomain transcription factor Ptx1
33. Regulation of type 1 interferon gene expression by in-terferon regulatory factor-3
34. Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3
35. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction
36. Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity
37. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of in-terferon A genes
38. Lipopolysaccharide inhibits virus-mediated induction of interferon genes by disruption of nuclear transport of interferon regulatory factors 3 and 7
39. Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300
40. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein
41. Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factors
42. The growing family of interferon regulatory factors
43. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
44. Unique properties of a second human herpesvirus 8-encoded interferon regulatory factor (vIRF-2)
45. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation
46. The cell cycle control element of histone H4 gene transcription is maximally responsive to interferon regulatory factor pairs IRF-1/IRF-3 and IRF-1/IRF-7
47. Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes
48. Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF-3 and CBP/p300
49. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1
50. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediate d degradation
51. Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription
52. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1
53. Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene
54. Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon and silencing by hy-permethylation
55. Monocyte differentiation to macrophage requires interferon regulatory factor 7
56. The Ep-stein-Barr virus EBNA-1 promoter Qp requires an initiator-like element
57. IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency
58. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
59. Downregulation of IRF-3 levels by ribozyme modulates the profile of IFNA subtypes expressed in infected human cells
60. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain
61. Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3
62. Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA
63. Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors
64. Multiple regulatory domains control IRF-7 activity in response to virus infection
65. Virus induction of human IFN-α gene expression requires the assembly of an enhanceosome
66. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter
67. The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness
68. Differential expression of human interferon genes
69. Stimulation of interferon and cytokine gene expression by imiquimod and stimulation by Sendai virus utilize similar signal transduction pathways
70. Relative transcriptional inducibility of the human in-terferon-alpha subtypes conferred by the virus-responsive enhancer sequence
71. Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32
72. Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300
73. Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3
74. Human type I interferons differ greatly in their effects on the proliferation of primary B cells
75. Different relative activities of human cell-derived interferon-alpha subtypes: IFN-alpha 8 has very high antiviral potency
76. Comparative analyses of IRF-3, IRF-7 and IFNA gene expression in human type 2 dendritic cell (DC2) precursors vs. monocytes and monocyte derived DC1
77. A weak signal for strong responses: Interferon-alpha/beta revisited
78. Identification of the rel family members required for virus induction of the human beta interferon gene
79. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
80. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body cavity-based lymphomas
81. KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway
82. Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays
83. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor
84. Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription
85. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor confers resistance to the antiproliferative effect of interferon-alpha
86. Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors
87. Inhibition of p53 tumor suppressor by viral interferon regulatory factor
88. Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) binds to, and inhibits transactivation of, CREB-binding protein
89. Inhibition of p300 histone acetyl-transferase by viral interferon regulatory factor
90. HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators
91. Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase
92. Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53
93. Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)
94. Regulation of DNA-raised immune responses by co-transfected interferon regulatory factors