Implications of human genetic variation in CRISPR-based therapeutic genome editing

Nature Medicine

Volumn 23, Issue 9, 2017, Pages 1095-1101

  Scott, David A ^a,b,c   Zhang, Feng ^a,b,c,d  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; GUIDE RNA;

ALLELE; ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; EXOME; EXON; GENE EDITING; GENE FREQUENCY; GENE TARGETING; GENETIC VARIATION; HAPLOTYPE; HUMAN; HUMAN GENOME; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WHOLE GENOME SEQUENCING; PRINCIPAL COMPONENT ANALYSIS;

CRISPR-CAS SYSTEMS; ENDONUCLEASES; GENE EDITING; GENE TARGETING; GENETIC VARIATION; HUMANS; PRINCIPAL COMPONENT ANALYSIS; RNA, GUIDE;

EID: 85029036015     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4377     Document Type: Article

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