Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes

Angewandte Chemie - International Edition

Volumn 56, Issue 42, 2017, Pages 13011-13015

  Liu, Renhe ^a   Lyu, Xiaoxuan ^a   Batt, Sarah M ^b   Hsu, Mei Hui ^c   Harbut, Michael B ^a   Vilchèze, Catherine ^d   Cheng, Bo ^a   Ajayi, Kehinde ^a   Yang, Baiyuan ^a   Yang, Yun ^a   Guo, Hui ^a   Lin, Changyou ^a   Gan, Fei ^a   Wang, Chen ^a   Franzblau, Scott G ^e   Jacobs, William R ^d   Besra, Gurdyal S ^b   Johnson, Eric F ^c   Petrassi, Mike ^a   Chatterjee, Arnab K ^a   Fütterer, Klaus ^b   Wang, Feng ^a   more..

^a California Institute for Biomedical Research   (United States)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

anti tubercular drugs; CYP2C9; DprE1; drug development; drug drug interactions

Indexed keywords

BIOCHEMISTRY; CRYSTAL STRUCTURE;

ANTI TUBERCULARS; CYP2C9; DPRE1; DRUG DEVELOPMENT; DRUG-DRUG INTERACTIONS;

DRUG INTERACTIONS;

BACTERIAL PROTEIN; CYTOCHROME P450 2C9; THIOPHENE DERIVATIVE; TUBERCULOSTATIC AGENT;

ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIBIOTIC RESISTANCE; BINDING SITE; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVE SITE; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR DYNAMICS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS; VETERINARY MEDICINE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 CYP2C9; DRUG RESISTANCE, BACTERIAL; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR DYNAMICS SIMULATION; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TUBERCULOSIS;

EID: 85028927430     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201707324     Document Type: Article

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