Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes

Science

Volumn 319, Issue 5864, 2008, Pages 819-821

  Krishnakumar, Raga ^a   Gamble, Matthew J ^a   Frizzell, Kristine M ^a   Berrocal, Jhoanna G ^a   Kininis, Miltiadis ^a   Kraus, W Lee ^a,b  

^a Department of Obstetrics Gynecology   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; RNA POLYMERASE II; SHORT HAIRPIN RNA;

ENZYME; GENE EXPRESSION; GENOME; PROTEIN; RNA;

ARTICLE; CELL STRAIN MCF 7; CHROMATIN STRUCTURE; DROSOPHILA; GENE CONTROL; GENE EXPRESSION; GENE LOCATION; GENETIC TRANSCRIPTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

CELL LINE, TUMOR; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION REGULATION; HISTONES; HUMANS; NUCLEOSOMES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLY(ADP-RIBOSE) POLYMERASES; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RNA POLYMERASE II; TRANSCRIPTION, GENETIC;

EID: 38949198773     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1149250     Document Type: Article

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24. We thank J. Lis, A. Clark, A. Siepel, and N. Hah for critical reading of this manuscript and A. Clark and members of the Kraus laboratory for technical advice and helpful discussions. This work was supported by grants from the NIH-National Institute of Diabetes and Digestive and Kidney Diseases (DK069710 and DK058110), the Cornell Center of Vertebrate Genomics, and the Endocrine Society (W.L.K.); a postdoctoral fellowship from the American Heart Association (M.J.G.); and predoctoral fellowships from the American Heart Association (K.M.F.), the Alfred P. Sloan Foundation (J.G.B.), and the Department of Defense Breast Cancer Research Program (M.K.).