Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 14, 2016, Pages 3797-3802

  El Gamal, Abrahim ^a   Agarwal, Vinayak ^a   Diethelm, Stefan ^a   Rahman, Imran ^a   Schorn, Michelle A ^a   Sneed, Jennifer M ^b   Louie, Gordon V ^c,d   Whalen, Kristen E ^e   Mincer, Tracy J ^e   Noel, Joseph P ^c,d   Paul, Valerie J ^b   Moore, Bradley S ^a,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SMITHSONIAN MARINE STATION   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^e WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Biosynthesis; Enzymology; Halogenation; Natural products

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BROMINASE; BROMINE DERIVATIVE; ENZYME; PYRROLE DERIVATIVE; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BROMINE; RIBOFLAVIN DERIVATIVE;

ARTICLE; BACTERIAL GENOME; BACTERIAL METABOLISM; BIOCATALYST; BIOSYNTHESIS; BROMINATION; CHLORINATION; CORAL; CRYSTAL STRUCTURE; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME RECONSTITUTION; GENE CLUSTER; GENE LOCUS; HALOGENATION; IN VITRO STUDY; MARINOMONAS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PSEUDOALTEROMONAS; REACTION TIME; SITE DIRECTED MUTAGENESIS; TRANSESTERIFICATION; AMINO ACID SEQUENCE; ANIMAL; ANTHOZOA; AQUATIC SPECIES; BINDING SITE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTHOZOA; AQUATIC ORGANISMS; BACTERIAL PROTEINS; BINDING SITES; BROMINE; CRYSTALLOGRAPHY, X-RAY; FLAVINS; HALOGENATION; PSEUDOALTEROMONAS; PYRROLES;

EID: 84962717976     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519695113     Document Type: Article

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