Coumarin-benzimidazole hybrids as a potent antimicrobial agent: Synthesis and biological elevation

Journal of Antibiotics

Volumn 70, Issue 9, 2017, Pages 954-961

  Singh, L Ravithej ^a   Avula, Srinivasa Rao ^a   Raj, Sneha ^a   Srivastava, Akanksha ^a   Palnati, Gopala Reddy ^a   Tripathi, C K M ^a   Pasupuleti, Mukesh ^a   Sashidhara, Koneni V ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 (3 METHYLBENZYLOXYIMINO)ETHYL] 2H CHROMEN 2 ONE; 3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 [(BENZYLOXY)IMINO]ETHYL] 2H CHROMEN 2 ONE; 3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 [3 (TRIFLUOROMETHYL)BENZYLOXYIMINO]ETHYL] 2H CHROMEN 2 ONE; 3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 [[(2,4 DIFLUOROBENZYL)OXY]IMINO]ETHYL] 2H CHROMEN 2 ONE; 3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 [[(2,5 DICHLOROBENZYL)OXY]IMINO]ETHYL] 2H CHROMEN 2 ONE; 3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 [[(3 CHLOROBENZYL)OXY]IMINO]ETHYL] 2H CHROMEN 2 ONE; 3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 [[(3 NITROBENZYL)OXY]IMINO]ETHYL] 2H CHROMEN 2 ONE; 3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 [[(4 BROMOBENZYL)OXY]IMINO]ETHYL] 2H CHROMEN 2 ONE; 3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 [[(4 CHLOROBENZYL)OXY]IMINO]ETHYL] 2H CHROMEN 2 ONE; 3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 [[(4 FLUOROBENZYL)OXY]IMINO]ETHYL] 2H CHROMEN 2 ONE; 3 [2 (1H BENZO[D]IMIDAZOL 1 YL) 1 [[(4 METHOXYBENZYL)OXY]IMINO]ETHYL] 2H CHROMEN 2 ONE; AMPICILLIN; BENZIMIDAZOLE; CHLORINE; CIPROFLOXACIN; COUMARIN; KANAMYCIN; TETRACYCLINE; UNCLASSIFIED DRUG; (E)-3-(2-1H-BENZO(D)IMIDAZOL-1-YL)-1-((4-CHLOROBENZYL)OXY)IMINO)ETHYL)-2H-CHROMEN-2-ONE; ANTIINFECTIVE AGENT; BENZIMIDAZOLE DERIVATIVE; CHLORINATED HYDROCARBON; COUMARIN DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HEMOLYSIS; HEMOLYSIS ASSAY; HYBRID; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEUS VULGARIS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CONNECTIVE TISSUE CELL; CYTOLOGY; DRUG DESIGN; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MICROBIAL SENSITIVITY TEST; MOLECULAR MODEL; MOUSE; MULTIDRUG RESISTANCE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; BACILLUS SUBTILIS; BENZIMIDAZOLES; CELL LINE; CELL SURVIVAL; CONNECTIVE TISSUE CELLS; COUMARINS; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HEMOLYSIS; HUMANS; HYDROCARBONS, CHLORINATED; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEUS VULGARIS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85028529749     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2017.70     Document Type: Article

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