Coumarin-based inhibitors of bacillus anthracis and staphylococcus aureus replicative DNA helicase: Chemical optimization, biological evaluation, and antibacterial activities

Journal of Medicinal Chemistry

Volumn 55, Issue 24, 2012, Pages 10896-10908

  Li, Bing ^a   Pai, Ramdas ^a   Di, Ming ^a   Aiello, Daniel ^a   Barnes, Marjorie H ^a   Butler, Michelle M ^a   Tashjian, Tommy F ^a   Peet, Norton P ^a   Bowlin, Terry L ^a   Moir, Donald T ^a  

^a MICROBIOTIX INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [4,8 DIMETHYL 2 OXO 7 (PROP 2 YNYLOXY) 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [4,8 DIMETHYL 2 OXO 7 (PYRIDIN 4 YLMETHOXY) 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [4,8 DIMETHYL 2 OXO 7 [(4' TRIFLUOROMETHYLBIPHENYL 4 YL)METHOXY] 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [4,8 DIMETHYL 7 (NAPHTHALEN 2 YLMETHOXY) 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (ALLYLOXY) 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (ANTHRACEN 9 YLMETHOXY) 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (BENZYLOXY) 4, 8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (BIPHENYL 2 YLMETHOXY) 4 METHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (BIPHENYL 2 YLMETHOXY) 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (BIPHENYL 3 YLMETHOXY) 4 METHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (BIPHENYL 3 YLMETHOXY) 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (BIPHENYL 4 YLMETHOXY) 4 METHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (BIPHENYL 4 YLMETHOXY) 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (ISOQUINOLIN 1 YLMETHOXY) 4 METHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 (ISOQUINOLIN 1 YLMETHOXY) 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 [(2' CYANOBIPHENYL 4 YL)METHOXY] 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 [(3',4' DICHLOROBIPHENYL 4 YL)METHOXY] 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 [(4' CHLOROBIPHENYL 4 YL)METHOXY] 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 [(4' FLUOROBIPHENYL 4 YL)METHOXY] 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 [(7 CHLOROQUINOLIN 2 YL)METHOXY] 4 METHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 3 [7 [(7 CHLOROQUINOLIN 2 YL)METHOXY] 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOIC ACID; 7 [(2',4' DIFLUOROBIPHENYL 4 YL)METHOXY] 4,8 DIMETHYL 3 (3 CARBOXYPROPYL) 2 OXO 2H CHROMENE; ANTIBIOTIC AGENT; CIPROFLOXACIN; COUMARIN DERIVATIVE; DOUBLE STRANDED DNA; ETHYL 3 [7 [(4 BROMOBENZYL)OXY] 4,8 DIMETHYL 2 OXO 2H CHROMEN 3 YL]PROPANOATE; HELICASE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACILLUS ANTHRACIS; CIPROFLOXACIN; COUMARINS; DNA, BACTERIAL; DNA, SINGLE-STRANDED; DNAB HELICASES; DRUG RESISTANCE, BACTERIAL; ENZYME ASSAYS; FLUORESCENCE RESONANCE ENERGY TRANSFER; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84871648732     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300922h     Document Type: Article

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