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Volumn 9, Issue 14, 1999, Pages 2079-2084

Synthesis and in vitro evaluation of novel highly potent coumarin inhibitors of gyrase B

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYCOUMARIN DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CYANAMIDE; DICHLOROMETHANE; DNA TOPOISOMERASE (ATP HYDROLYSING); ERYTHROMYCIN; GYRASE INHIBITOR; N ACYLAMINO ACID; NOVOBIOCIN; OFLOXACIN; TEICOPLANIN; TETRAHYDROFURAN; VANCOMYCIN;

EID: 0033584164     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00329-7     Document Type: Article
Times cited : (164)

References (29)
  • 4
    • 0026015132 scopus 로고
    • For a review of gyrase structure and function see
    • For a review of gyrase structure and function see: Reece, R. J.; Maxwell, A. Crit. Rev. Biochem. Mol. Biol. 1991, 26, 335-375.
    • (1991) Crit. Rev. Biochem. Mol. Biol. , vol.26 , pp. 335-375
    • Reece, R.J.1    Maxwell, A.2
  • 20
    • 0009594475 scopus 로고    scopus 로고
    • note
    • We successfully solved X-ray crystal structures of several coumarin derivatives with 24 kDa N-terminal fragment of gyrase B in collaboration with P. Oudet and D. Moras at the University of Louis Pasteur, Illkirch, France, unpublished results.
  • 28
    • 0009631404 scopus 로고    scopus 로고
    • note
    • In all cases 19a-d, only the isomer with E-geometry was observed, as confirmed by NOE experiments. This could be attributed to the strong intramolecular hydrogen bond between the hydrogen of the 4-OH of coumarin and N-atom of the oxime.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.