Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5697-5700

  Tambo Ong, Arlyn ^a   Chopra, Sidharth ^a   Glaser, Bryan T ^a   Matsuyama, Karen ^a   Tran, Tran ^a   Madrid, Peter B ^a  

^a SRI INTERNATIONAL   (United States)

Author keywords

Aminocoumarin; Antibacterial; Gyrase B; Novobiocin; Tuberculosis

Indexed keywords

NOVOBIOCIN; NOVOBIOCIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG POTENCY; ESCHERICHIA COLI; FRANCISELLA TULARENSIS; MANNICH REACTION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSICAL CHEMISTRY; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; CELL MEMBRANE; DNA GYRASE; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; MANNICH BASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NOVOBIOCIN; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; FRANCISELLA TULARENSIS; MYCOBACTERIUM TUBERCULOSIS; STAPHYLOCOCCUS AUREUS;

EID: 80052596207     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.035     Document Type: Article

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