Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 2202-2210

  Zhang, Datong ^a   Wang, Zongheng ^a   Xu, Weiren ^b   Sun, Fanggang ^a   Tang, Lida ^b   Wang, Jianwu ^a  

^a SHANDONG UNIVERSITY   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Actinonin derivatives; Antibacterial activity; Benzimidazole; Synthesis

Indexed keywords

2 [1 BENZYLOXYCARBONYLAMINO 2 METHYL]PROPYL 5 (1 MORPHOLIN)CARBONYLBENZIMIDAZOLE; 2 [1 BENZYLOXYCARBONYLAMINO 2 METHYL]PROPYL 5 (4 METHOXYANILINO)CARBONYLBENZIMIDAZOLE; 2 BUTYL N 4 HYDROXY N 1 [1 (S) (5 METHOXYBENZIMIDAZOL 2 YL) 2 METHYL]PROPYLSUCCINAMIDE; 2 BUTYL N 4 HYDROXY N 1 [1 (S) (5 METHYLBENZIMIDAZOL 2 YL) 2 METHYL]PROPYLSUCCINAMIDE; 2 BUTYL N 4 HYDROXY N 1 [1 (S) (BENZIMIDAZOL 2 YL) 2 METHYL]PROPYLSUCCINAMIDE; 2 BUTYL N 4 HYDROXY N 1 [1 (S) [(5 PIPERIDINOCARBONYL)BENZIMIDAZOL 2 YL] 2 METHYL]PROPYLSUCCINAMIDE; 2 BUTYL N 4 HYDROXY N 1 [1 (S) [5 (MORPHOLINOCARBONYL)BENZIMIDAZOL 2 YL] 2METHYL]PROPYLSUCCINAMIDE; 2 BUTYL N 4 HYDROXY N 1 [1 (S) [[5 (4 METHOXYANILINO)CARBONYL]BENZIMIDAZOL 2 YL] 2 METHYL]PROPYLSUCCINAMIDE; 2 BUTYL N 4 HYDROXY N 1[1 (S) [[5 (CYCLOHEXYLAMINO)CARBONYL]BENZIMIDAZOL 2 YL] 2 METHYL]PROPYLSUCCINAMIDE; ACTINONIN; BENZIMIDAZOLE; N [1 (S) (5 METHOXYBENZIMIDAZOL 2 YL) 2 METHYL]PROPYL 2 METHOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) (5 METHOXYBENZIMIDAZOL 2 YL) 2 METHYL]PROPYL 2 TERTBUTOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) (5 METHYLBENZIMIDAZOL 2 YL) 2 METHYL] PROPYL 2 METHOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) (5 METHYLBENZIMIDAZOL 2 YL) 2 METHYL]PROPYL 2 TERTBUTOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) (BENZIMIDAZOL 2 YL) 2 METHYL]PROPYL 2 METHOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) (BENZIMIDAZOL 2 YL) 2 METHYL]PROPYL 2 TERTBUTOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) [5 (CYCLOHEXYLAMINOCARBONYL)BENZIMIDAZOL 2 YL] 2 METHYL]PROPYL 2 METHOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) [5 (MORPHOLINOCARBONYL)BENZIMIDAZOL 2 YL] 2 METHYL]PROPYL 2 METHOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) [5 (MORPHOLINOCARBONYL)BENZIMIDAZOL 2 YL] 2 METHYL]PROPYL 2 TERTBUTOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) [5 (PIPERIDINOCARBONYL)BENZIMIDAZOL 2 YL] 2 METHYL]PROPYL 2 METHOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) [5 (PIPERIDINOCARBONYL)BENZIMIDAZOL 2 YL] 2 METHYL]PROPYL 2 TERTBUTOXYCARBONYLMETHYLHEXANAMIDE; N [1 (S) [[5 (4 METHOXYANILINO)CARBONYL]BENZIMIDAZOL 2 YL] 2 METHYL]PROPYL 2 METHOXYCARBONYLMETHYLHEXANAMIDE; N [2 AMINO 5 (CYCLOHEXYLAMINO)CARBONYL]PHENYL 3 METHYL 2 (S) BENZYLOXYCARBONYLAMINOBUTAMIDE; N [2 AMINO 5 (PIPERIDINO)CARBONYL]PHENYL 3 METHYL 2 (S) BENZYLOXYCARBONYLAMINOBUTAMIDE; N BENZYLOXYCARBONYL [1 (5 METHOXYLBENZIMIDAZOL 2 YL)] 2 METHYLPROPYLAMINE; N BENZYLOXYCARBONYL(1 BENZIMIDAZOL 2 YL) 2 METHYLPROPYLAMINE; N BENZYLOXYCARBONYL[1 (5 METHYLBENZIMIDAZOL 2 YL)] 2 METHYLPROPYLAMINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MICROCOCCUS LUTEUS; MINIMUM INHIBITORY CONCENTRATION; SPECTROSCOPY; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BENZIMIDAZOLES; DRUG DESIGN; HYDROXAMIC ACIDS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; SARCINA; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62549145285     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.05.009     Document Type: Article

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