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Volumn 8, Issue AUG, 2017, Pages

Anti-fibrotic potential of AT2 receptor agonists

Author keywords

AT2 receptor; Cardiac fibrosis; Compound 21; Inflammation; Renal fibrosis

Indexed keywords


EID: 85028471491     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2017.00564     Document Type: Article
Times cited : (76)

References (73)
  • 1
    • 0034601761 scopus 로고    scopus 로고
    • Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice
    • Akishita, M., Iwai, M., Wu, L., Zhang, L., Ouchi, Y., Dzau, V. J., et al. (2000). Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice. Circulation 102, 1684–1689. doi: 10.1161/01.CIR.102.14.1684
    • (2000) Circulation , vol.102 , pp. 1684-1689
    • Akishita, M.1    Iwai, M.2    Wu, L.3    Zhang, L.4    Ouchi, Y.5    Dzau, V.J.6
  • 2
    • 0027316963 scopus 로고
    • Myocardial electrical propagation in patients with idiopathic dilated cardiomyopathy
    • Anderson, K. P., Walker, R., Urie, P., Ershler, P. R., Lux, R. L., and Karwandee, S. V. (1993). Myocardial electrical propagation in patients with idiopathic dilated cardiomyopathy. J. Clin. Invest. 92, 122–140. doi: 10.1172/JCI116540
    • (1993) J. Clin. Invest. , vol.92 , pp. 122-140
    • Anderson, K.P.1    Walker, R.2    Urie, P.3    Ershler, P.R.4    Lux, R.L.5    Karwandee, S.V.6
  • 3
    • 85004143373 scopus 로고    scopus 로고
    • Renin angiotensin aldosterone system inhibitors in hypertension: is there evidence for benefit independent of blood pressure reduction? Prog
    • Bavishi, C., Bangalore, S., and Messerli, F. H. (2016). Renin angiotensin aldosterone system inhibitors in hypertension: is there evidence for benefit independent of blood pressure reduction? Prog. Cardiovasc. Dis. 59, 253–261. doi: 10.1016/j.pcad.2016.10.002
    • (2016) Cardiovasc. Dis. , vol.59 , pp. 253-261
    • Bavishi, C.1    Bangalore, S.2    Messerli, F.H.3
  • 4
    • 33847347313 scopus 로고    scopus 로고
    • ECM remodeling in hypertensive heart disease
    • Berk, B. C., Fujiwara, K., and Lehoux, S. (2007). ECM remodeling in hypertensive heart disease. J. Clin. Invest. 117, 568–575. doi: 10.1172/JCI31044
    • (2007) J. Clin. Invest. , vol.117 , pp. 568-575
    • Berk, B.C.1    Fujiwara, K.2    Lehoux, S.3
  • 5
    • 80054084671 scopus 로고    scopus 로고
    • Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors
    • Bosnyak, S., Jones, E. S., Christopoulos, A., Aguilar, M. I., Thomas, W. G., and Widdop, R. E. (2011). Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin. Sci. 121, 297–303. doi: 10.1042/CS20110036
    • (2011) Clin. Sci. , vol.121 , pp. 297-303
    • Bosnyak, S.1    Jones, E.S.2    Christopoulos, A.3    Aguilar, M.I.4    Thomas, W.G.5    Widdop, R.E.6
  • 6
    • 10744219938 scopus 로고    scopus 로고
    • Nitric oxide mediates benefits of angiotensin II type 2 receptor overexpression during post-infarct remodeling
    • Bove, C. M., Yang, Z., Gilson, W. D., Epstein, F. H., French, B. A., Berr, S. S., et al. (2004). Nitric oxide mediates benefits of angiotensin II type 2 receptor overexpression during post-infarct remodeling. Hypertension 43, 680–685. doi: 10.1161/01.HYP.0000115924.94236.91
    • (2004) Hypertension , vol.43 , pp. 680-685
    • Bove, C.M.1    Yang, Z.2    Gilson, W.D.3    Epstein, F.H.4    French, B.A.5    Berr, S.S.6
  • 7
    • 0034687149 scopus 로고    scopus 로고
    • Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease
    • Brilla, C. G., Funck, R. C., and Rupp, H. (2000). Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease. Circulation 102, 1388–1393. doi: 10.1161/01.CIR.102.12.1388
    • (2000) Circulation , vol.102 , pp. 1388-1393
    • Brilla, C.G.1    Funck, R.C.2    Rupp, H.3
  • 8
    • 84926621346 scopus 로고    scopus 로고
    • Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis
    • Bruce, E., Shenoy, V., Rathinasabapathy, A., Espejo, A., Horowitz, A., Oswalt, A., et al. (2015). Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br. J. Pharmacol. 172, 2219–2231. doi: 10.1111/bph.13044
    • (2015) Br. J. Pharmacol. , vol.172 , pp. 2219-2231
    • Bruce, E.1    Shenoy, V.2    Rathinasabapathy, A.3    Espejo, A.4    Horowitz, A.5    Oswalt, A.6
  • 9
    • 0023120913 scopus 로고
    • Circulating and tissue angiotensin systems
    • Campbell, D. J. (1987). Circulating and tissue angiotensin systems. J. Clin. Invest. 79, 1–6. doi: 10.1172/JCI112768
    • (1987) J. Clin. Invest. , vol.79 , Issue.1 , pp. 6
    • Campbell, D.J.1
  • 10
    • 85000925662 scopus 로고    scopus 로고
    • Update on angiotensin AT2 receptors
    • Carey, R. M. (2017). Update on angiotensin AT2 receptors. Curr. Opin. Nephrol. Hypertens 26, 91–96. doi: 10.1097/MNH.0000000000000304
    • (2017) Curr. Opin. Nephrol. Hypertens , vol.26 , pp. 91-96
    • Carey, R.M.1
  • 11
    • 84916633473 scopus 로고    scopus 로고
    • Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats
    • Castoldi, G., di Gioia, C. R., Bombardi, C., Maestroni, S., Carletti, R., Steckelings, U. M., et al. (2014). Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats. Am. J. Physiol. Renal Physiol. 307, F1123–F1131. doi: 10.1152/ajprenal.00247.2014
    • (2014) Am. J. Physiol. Renal Physiol. , vol.307 , pp. F1123-F1131
    • Castoldi, G.1    di Gioia, C.R.2    Bombardi, C.3    Maestroni, S.4    Carletti, R.5    Steckelings, U.M.6
  • 12
    • 84903773477 scopus 로고    scopus 로고
    • Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis
    • Chow, B. S., Kocan, M., Bosnyak, S., Sarwar, M., Wigg, B., Jones, E. S., et al. (2014). Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis. Kidney Int. 86, 75–85. doi: 10.1038/ki.2013.518
    • (2014) Kidney Int. , vol.86 , pp. 75-85
    • Chow, B.S.1    Kocan, M.2    Bosnyak, S.3    Sarwar, M.4    Wigg, B.5    Jones, E.S.6
  • 13
    • 84942809272 scopus 로고    scopus 로고
    • I., et al. (2015). β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats
    • doi
    • Del Borgo, M. P., Wang, Y., Bosnyak, S., Khan, M., Walters, P., Spizzo, I., et al. (2015). β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats. Clin. Sci. 129, 505–513. doi: 10.1042/CS20150077
    • Clin. Sci. , vol.129 , pp. 505-513
    • Borgo, D.1    Wang, M.P.2    Bosnyak, Y.3    Khan, S.4    Walters, M.5    Spizzo, P.6
  • 14
    • 0027212686 scopus 로고
    • Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
    • Desmouliere, A., Geinoz, A., Gabbiani, F., and Gabbiani, G. (1993). Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J. Cell Biol. 122, 103–111. doi: 10.1083/jcb.122.1.103
    • (1993) J. Cell Biol. , vol.122 , pp. 103-111
    • Desmouliere, A.1    Geinoz, A.2    Gabbiani, F.3    Gabbiani, G.4
  • 15
    • 0037188574 scopus 로고    scopus 로고
    • Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients
    • Diez, J., Querejeta, R., Lopez, B., Gonzalez, A., Larman, M., and Martinez Ubago, J. L. (2002). Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients. Circulation 105, 2512–2517. doi: 10.1161/01.CIR.0000017264.66561.3D
    • (2002) Circulation , vol.105 , pp. 2512-2517
    • Diez, J.1    Querejeta, R.2    Lopez, B.3    Gonzalez, A.4    Larman, M.5    Martinez Ubago, J.L.6
  • 16
    • 33745162185 scopus 로고    scopus 로고
    • Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease
    • Ferrario, C. M., and Strawn, W. B. (2006). Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease. Am. J. Cardiol. 98, 121–128. doi: 10.1016/j.amjcard.2006.01.059
    • (2006) Am. J. Cardiol. , vol.98 , pp. 121-128
    • Ferrario, C.M.1    Strawn, W.B.2
  • 17
    • 0032005821 scopus 로고    scopus 로고
    • Interleukin-1 in myocardium and coronary arteries of patients with dilated cardiomyopathy
    • Francis, S. E., Holden, H., Holt, C. M., and Duff, G. W. (1998). Interleukin-1 in myocardium and coronary arteries of patients with dilated cardiomyopathy. J. Mol. Cell Cardiol. 30, 215–223. doi: 10.1006/jmcc.1997.0592
    • (1998) J. Mol. Cell Cardiol. , vol.30 , pp. 215-223
    • Francis, S.E.1    Holden, H.2    Holt, C.M.3    Duff, G.W.4
  • 18
    • 73649119592 scopus 로고    scopus 로고
    • Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage
    • Gelosa, P., Pignieri, A., Fandriks, L., de Gasparo, M., Hallberg, A., Banfi, C., et al. (2009). Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. J. Hypertens. 27, 2444–2451. doi: 10.1097/HJH.0b013e3283311ba1
    • (2009) J. Hypertens. , vol.27 , pp. 2444-2451
    • Gelosa, P.1    Pignieri, A.2    Fandriks, L.3    de Gasparo, M.4    Hallberg, A.5    Banfi, C.6
  • 19
    • 80053360926 scopus 로고    scopus 로고
    • cGMP inhibits TGF-beta signaling by sequestering Smad3 with cytosolic beta2-tubulin in pulmonary artery smooth muscle cells
    • Gong, K., Xing, D., Li, P., Hilgers, R. H., Hage, F. G., Oparil, S., et al. (2011). cGMP inhibits TGF-beta signaling by sequestering Smad3 with cytosolic beta2-tubulin in pulmonary artery smooth muscle cells. Mol. Endocrinol. 25, 1794–1803. doi: 10.1210/me.2011-1009
    • (2011) Mol. Endocrinol. , vol.25 , pp. 1794-1803
    • Gong, K.1    Xing, D.2    Li, P.3    Hilgers, R.H.4    Hage, F.G.5    Oparil, S.6
  • 21
    • 84877334814 scopus 로고    scopus 로고
    • Renin-angiotensin system: upgrade of recent knowledge and perspectives
    • Herichova, I., and Szantoova, K. (2013). Renin-angiotensin system: upgrade of recent knowledge and perspectives. Endocr. Regul. 47, 39–52. doi: 10.4149/ endo_2013_01_39
    • (2013) Endocr. Regul. , vol.47 , pp. 39-52
    • Herichova, I.1    Szantoova, K.2
  • 22
    • 84891658499 scopus 로고    scopus 로고
    • Protective effect of captopril, olmesartan, melatonin and compound 21 on doxorubicin-induced nephrotoxicity in rats
    • Hrenak, J., Arendasova, K., Rajkovicova, R., Aziriova, S., Repova, K., Krajcirovicova, K., et al. (2013). Protective effect of captopril, olmesartan, melatonin and compound 21 on doxorubicin-induced nephrotoxicity in rats. Physiol. Res. 62(Suppl. 1), S181–S189.
    • (2013) Physiol. Res. , vol.62 , pp. S181-S189
    • Hrenak, J.1    Arendasova, K.2    Rajkovicova, R.3    Aziriova, S.4    Repova, K.5    Krajcirovicova, K.6
  • 23
    • 36849028767 scopus 로고    scopus 로고
    • Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling
    • Isbell, D. C., Voros, S., Yang, Z., DiMaria, J. M., Berr, S. S., French, B. A., et al. (2007). Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling. Am. J. Physiol. Heart Circ. Physiol. 293, H3372–H3378. doi: 10.1152/ajpheart.00997.2007
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.293 , pp. H3372-H3378
    • Isbell, D.C.1    Voros, S.2    Yang, Z.3    DiMaria, J.M.4    Berr, S.S.5    French, B.A.6
  • 24
    • 79953216990 scopus 로고    scopus 로고
    • A single β-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function
    • Jones, E. S., Del Borgo, M. P., Kirsch, J. F., Clayton, D., Bosnyak, S., Welungoda, I., et al. (2011). A single β-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function. Hypertension 57, 570–576. doi: 10.1161/HYPERTENSIONAHA.110.164301
    • (2011) Hypertension , vol.57 , pp. 570-576
    • Jones, E.S.1    Del Borgo, M.P.2    Kirsch, J.F.3    Clayton, D.4    Bosnyak, S.5    Welungoda, I.6
  • 25
    • 56149096807 scopus 로고    scopus 로고
    • AT2 receptors: functional relevance in cardiovascular disease
    • Jones, E. S., Vinh, A., McCarthy, C. A., Gaspari, T. A., and Widdop, R. E. (2008). AT2 receptors: functional relevance in cardiovascular disease. Pharmacol. Ther. 120, 292–316. doi: 10.1016/j.pharmthera.2008.08.009
    • (2008) Pharmacol. Ther. , vol.120 , pp. 292-316
    • Jones, E.S.1    Vinh, A.2    McCarthy, C.A.3    Gaspari, T.A.4    Widdop, R.E.5
  • 26
    • 84942014315 scopus 로고    scopus 로고
    • International union of basic and clinical pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli [corrected]
    • Karnik, S. S., Unal, H., Kemp, J. R., Tirupula, K. C., Eguchi, S., Vanderheyden, P. M., et al. (2015). International union of basic and clinical pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli [corrected]. Pharmacol. Rev. 67, 754–819. doi: 10.1124/pr.114.010454
    • (2015) Pharmacol. Rev. , vol.67 , pp. 754-819
    • Karnik, S.S.1    Unal, H.2    Kemp, J.R.3    Tirupula, K.C.4    Eguchi, S.5    Vanderheyden, P.M.6
  • 27
    • 58149375072 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction
    • Kaschina, E., Grzesiak, A., Li, J., Foryst-Ludwig, A., Timm, M., Rompe, F., et al. (2008). Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 118, 2523–2532. doi: 10.1161/CIRCULATIONAHA.108.784868
    • (2008) Circulation , vol.118 , pp. 2523-2532
    • Kaschina, E.1    Grzesiak, A.2    Li, J.3    Foryst-Ludwig, A.4    Timm, M.5    Rompe, F.6
  • 28
    • 85013853157 scopus 로고    scopus 로고
    • EMA401: an old antagonist of the AT2R for a new indication in neuropathic pain
    • Keppel Hesselink, J. M., and Schatman, M. E. (2017). EMA401: an old antagonist of the AT2R for a new indication in neuropathic pain. J. Pain Res. 10, 439–443. doi: 10.2147/JPR.S128520
    • (2017) J. Pain Res. , vol.10 , pp. 439-443
    • Keppel Hesselink, J.M.1    Schatman, M.E.2
  • 29
    • 84930989439 scopus 로고    scopus 로고
    • AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy
    • Koulis, C., Chow, B. S., McKelvey, M., Steckelings, U. M., Unger, T., Thallas-Bonke, V., et al. (2015). AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy. Hypertension 65, 1073–1081. doi: 10.1161/HYPERTENSIONAHA.115.05204
    • (2015) Hypertension , vol.65 , pp. 1073-1081
    • Koulis, C.1    Chow, B.S.2    McKelvey, M.3    Steckelings, U.M.4    Unger, T.5    Thallas-Bonke, V.6
  • 30
    • 0037222491 scopus 로고    scopus 로고
    • Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis
    • Kurisu, S., Ozono, R., Oshima, T., Kambe, M., Ishida, T., Sugino, H., et al. (2003). Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis. Hypertension 41, 99–107. doi: 10.1161/01.HYP.0000050101.90932.14
    • (2003) Hypertension , vol.41 , pp. 99-107
    • Kurisu, S.1    Ozono, R.2    Oshima, T.3    Kambe, M.4    Ishida, T.5    Sugino, H.6
  • 31
    • 84894417555 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor beta1 in the rat heart
    • Lauer, D., Slavic, S., Sommerfeld, M., Thone-Reineke, C., Sharkovska, Y., Hallberg, A., et al. (2014). Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor beta1 in the rat heart. Hypertension 63, e60–e67. doi: 10.1161/HYPERTENSIONAHA.113.02522
    • (2014) Hypertension , vol.63 , pp. e60-e67
    • Lauer, D.1    Slavic, S.2    Sommerfeld, M.3    Thone-Reineke, C.4    Sharkovska, Y.5    Hallberg, A.6
  • 32
    • 0033813219 scopus 로고    scopus 로고
    • Induction of cardiac fibrosis by transforming growth factor-beta(1)
    • Lijnen, P. J., Petrov, V. V., and Fagard, R. H. (2000). Induction of cardiac fibrosis by transforming growth factor-beta(1). Mol. Genet. Metab. 71, 418–435. doi: 10.1006/mgme.2000.3032
    • (2000) Mol. Genet. Metab. , vol.71 , pp. 418-435
    • Lijnen, P.J.1    Petrov, V.V.2    Fagard, R.H.3
  • 33
    • 0032040212 scopus 로고    scopus 로고
    • Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction
    • Ma, J., Nishimura, H., Fogo, A., Kon, V., Inagami, T., and Ichikawa, I. (1998). Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int. 53, 937–944. doi: 10.1111/j.1523-1755.1998.00893.x
    • (1998) Kidney Int. , vol.53 , pp. 937-944
    • Ma, J.1    Nishimura, H.2    Fogo, A.3    Kon, V.4    Inagami, T.5    Ichikawa, I.6
  • 34
    • 84957309995 scopus 로고    scopus 로고
    • Differential effects of β-blockers, angiotensin II receptor blockers and a novel AT2R agonist NP-6A4 on stress response of nutrient-starved cardiovascular cells
    • Mahmood, A., and Pulakat, L. (2015). Differential effects of β-blockers, angiotensin II receptor blockers and a novel AT2R agonist NP-6A4 on stress response of nutrient-starved cardiovascular cells. PLoS ONE 10:e0144824. doi: 10.1371/journal.pone.0144824
    • (2015) PLoS ONE , vol.10 , pp. e0144824
    • Mahmood, A.1    Pulakat, L.2
  • 35
    • 84874318834 scopus 로고    scopus 로고
    • Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials
    • BMJ
    • Makani, H., Bangalore, S., Desouza, K. A., Shah, A., and Messerli, F. H. (2013). Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials. BMJ 346:f360. doi: 10.1136/bmj.f360
    • (2013) , vol.346 , pp. f360
    • Makani, H.1    Bangalore, S.2    Desouza, K.A.3    Shah, A.4    Messerli, F.H.5
  • 36
    • 79551505061 scopus 로고    scopus 로고
    • Angiotensin AT(2) receptor stimulation inhibits early renal inflammation in renovascular hypertension
    • Matavelli, L. C., Huang, J., and Siragy, H. M. (2011). Angiotensin AT(2) receptor stimulation inhibits early renal inflammation in renovascular hypertension. Hypertension 57, 308–313. doi: 10.1161/HYPERTENSIONAHA.110.164202
    • (2011) Hypertension , vol.57 , pp. 308-313
    • Matavelli, L.C.1    Huang, J.2    Siragy, H.M.3
  • 37
    • 84939998893 scopus 로고    scopus 로고
    • A nonpeptide angiotensin II type 2 receptor agonist prevents renal inflammation in early diabetes
    • Matavelli, L. C., Zatz, R., and Siragy, H. M. (2015). A nonpeptide angiotensin II type 2 receptor agonist prevents renal inflammation in early diabetes. J. Cardiovasc. Pharmacol. 65, 371–376. doi: 10.1097/FJC.0000000000000207
    • (2015) J. Cardiovasc. Pharmacol. , vol.65 , pp. 371-376
    • Matavelli, L.C.1    Zatz, R.2    Siragy, H.M.3
  • 39
    • 33846362954 scopus 로고    scopus 로고
    • Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
    • Mehta, P. K., and Griendling, K. K. (2007). Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am. J. Physiol. Cell Physiol. 292, C82–C97.
    • (2007) Am. J. Physiol. Cell Physiol. , vol.292 , pp. C82-C97
    • Mehta, P.K.1    Griendling, K.K.2
  • 40
    • 77956904820 scopus 로고    scopus 로고
    • Of fads, fashion, surrogate endpoints and dual RAS blockade
    • Messerli, F. H., Staessen, J. A., and Zannad, F. (2010). Of fads, fashion, surrogate endpoints and dual RAS blockade. Eur. Heart J. 31, 2205–2208. doi: 10.1093/ eurheartj/ehq255
    • (2010) Eur. Heart J. , vol.31 , pp. 2205-2208
    • Messerli, F.H.1    Staessen, J.A.2    Zannad, F.3
  • 41
    • 2542499706 scopus 로고    scopus 로고
    • Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer
    • Metcalfe, B. L., Huentelman, M. J., Parilak, L. D., Taylor, D. G., Katovich, M. J., Knot, H. J., et al. (2004). Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer. Hypertension 43, 1233–1238. doi: 10.1161/01.HYP.0000127563.14064.fd
    • (2004) Hypertension , vol.43 , pp. 1233-1238
    • Metcalfe, B.L.1    Huentelman, M.J.2    Parilak, L.D.3    Taylor, D.G.4    Katovich, M.J.5    Knot, H.J.6
  • 42
    • 84898047210 scopus 로고    scopus 로고
    • 1990-2010 global cardiovascular disease atlas
    • Moran, A. E., Roth, G. A., Narula, J., and Mensah, G. A. (2014). 1990-2010 global cardiovascular disease atlas. Glob. Heart 9, 3–16. doi: 10.1016/j.gheart.2014.03.1220
    • (2014) Glob. Heart , vol.9 , pp. 3-16
    • Moran, A.E.1    Roth, G.A.2    Narula, J.3    Mensah, G.A.4
  • 43
    • 33745204406 scopus 로고    scopus 로고
    • Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis
    • Nabeshima, Y., Tazuma, S., Kanno, K., Hyogo, H., Iwai, M., Horiuchi, M., et al. (2006). Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis. Biochem. Biophys. Res. Commun. 346, 658–664. doi: 10.1016/j.bbrc.2006.05.183
    • (2006) Biochem. Biophys. Res. Commun. , vol.346 , pp. 658-664
    • Nabeshima, Y.1    Tazuma, S.2    Kanno, K.3    Hyogo, H.4    Iwai, M.5    Horiuchi, M.6
  • 44
    • 11144251584 scopus 로고    scopus 로고
    • Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction
    • Nakayama, M., Yan, X., Price, R. L., Borg, T. K., Ito, K., Sanbe, A., et al. (2005). Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction. Am. J. Physiol. Heart Circ. Physiol. 288, H317–H327.
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.288 , pp. H317-H327
    • Nakayama, M.1    Yan, X.2    Price, R.L.3    Borg, T.K.4    Ito, K.5    Sanbe, A.6
  • 45
    • 84881669408 scopus 로고    scopus 로고
    • Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle
    • Painemal, P., Acuña, M. J., Riquelme, C., Brandan, E., and Cabello-Verrugio, C. (2013). Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle. Biofactors 39, 467–475. doi: 10.1002/biof.1087
    • (2013) Biofactors , vol.39 , pp. 467-475
    • Painemal, P.1    Acuña, M.J.2    Riquelme, C.3    Brandan, E.4    Cabello-Verrugio, C.5
  • 46
    • 84856201427 scopus 로고    scopus 로고
    • Direct angiotensin II type 2 receptor stimulation in Nomega-nitro-L-arginine-methyl ester-induced hypertension: the effect on pulse wave velocity and aortic remodeling
    • Paulis, L., Becker, S. T., Lucht, K., Schwengel, K., Slavic, S., Kaschina, E., et al. (2012). Direct angiotensin II type 2 receptor stimulation in Nomega-nitro-L-arginine-methyl ester-induced hypertension: the effect on pulse wave velocity and aortic remodeling. Hypertension 59, 485–492. doi: 10.1161/HYPERTENSIONAHA.111.185496
    • (2012) Hypertension , vol.59 , pp. 485-492
    • Paulis, L.1    Becker, S.T.2    Lucht, K.3    Schwengel, K.4    Slavic, S.5    Kaschina, E.6
  • 47
    • 0031679963 scopus 로고    scopus 로고
    • Left-ventricular expression of interleukin-6 messenger-RNA higher in idiopathic dilated than in ischemic cardiomyopathy
    • Plenz, G., Song, Z. F., Reichenberg, S., Tjan, T. D., Robenek, H., and Deng, M. C. (1998). Left-ventricular expression of interleukin-6 messenger-RNA higher in idiopathic dilated than in ischemic cardiomyopathy. Thorac. Cardiovasc. Surg. 46, 213–216. doi: 10.1055/s-2007-1010227
    • (1998) Thorac. Cardiovasc. Surg. , vol.46 , pp. 213-216
    • Plenz, G.1    Song, Z.F.2    Reichenberg, S.3    Tjan, T.D.4    Robenek, H.5    Deng, M.C.6
  • 48
    • 84355162846 scopus 로고    scopus 로고
    • Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury
    • Qi, Y., Li, H., Shenoy, V., Li, Q., Wong, F., Zhang, L., et al. (2012). Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury. Exp. Physiol. 97, 89–101. doi: 10.1113/expphysiol.2011.060673
    • (2012) Exp. Physiol. , vol.97 , pp. 89-101
    • Qi, Y.1    Li, H.2    Shenoy, V.3    Li, Q.4    Wong, F.5    Zhang, L.6
  • 49
    • 4444229005 scopus 로고    scopus 로고
    • Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis
    • Querejeta, R., Lopez, B., Gonzalez, A., Sanchez, E., Larman, M., Martinez Ubago, J. L., et al. (2004). Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis. Circulation 110, 1263–1268. doi: 10.1161/01.CIR.0000140973.60992.9A
    • (2004) Circulation , vol.110 , pp. 1263-1268
    • Querejeta, R.1    Lopez, B.2    Gonzalez, A.3    Sanchez, E.4    Larman, M.5    Martinez Ubago, J.L.6
  • 50
    • 84856120678 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats
    • Rehman, A., Leibowitz, A., Yamamoto, N., Rautureau, Y., Paradis, P., and Schiffrin, E. L. (2012). Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension 59, 291–299. doi: 10.1161/HYPERTENSIONAHA.111.180158
    • (2012) Hypertension , vol.59 , pp. 291-299
    • Rehman, A.1    Leibowitz, A.2    Yamamoto, N.3    Rautureau, Y.4    Paradis, P.5    Schiffrin, E.L.6
  • 51
    • 84925060829 scopus 로고    scopus 로고
    • Fibrosis–A common pathway to organ injury and failure
    • Rockey, D. C., Bell, P. D., and Hill, J. A. (2015). Fibrosis–A common pathway to organ injury and failure. N. Engl. J. Med. 372, 1138–1149. doi: 10.1056/ NEJMra1300575
    • (2015) N. Engl. J. Med. , vol.372 , pp. 1138-1149
    • Rockey, D.C.1    Bell, P.D.2    Hill, J.A.3
  • 52
    • 77950472601 scopus 로고    scopus 로고
    • Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB
    • Rompe, F., Artuc, M., Hallberg, A., Alterman, M., Stroder, K., Thone-Reineke, C., et al. (2010). Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension 55, 924–931. doi: 10.1161/HYPERTENSIONAHA.109.147843
    • (2010) Hypertension , vol.55 , pp. 924-931
    • Rompe, F.1    Artuc, M.2    Hallberg, A.3    Alterman, M.4    Stroder, K.5    Thone-Reineke, C.6
  • 53
    • 84877035619 scopus 로고    scopus 로고
    • Strategies for anti-fibrotic therapies
    • Rosenbloom, J., Mendoza, F. A., and Jimenez, S. A. (2013). Strategies for anti-fibrotic therapies. Biochim. Biophys. Acta 1832, 1088–1103. doi: 10.1016/j.bbadis.2012.12.007
    • (2013) Biochim. Biophys. Acta , vol.1832 , pp. 1088-1103
    • Rosenbloom, J.1    Mendoza, F.A.2    Jimenez, S.A.3
  • 54
    • 0027182438 scopus 로고
    • Molecular characterization of angiotensin II–induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype
    • Sadoshima, J., and Izumo, S. (1993). Molecular characterization of angiotensin II–induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ. Res. 73, 413–423. doi: 10.1161/01.RES.73.3.413
    • (1993) Circ. Res. , vol.73 , pp. 413-423
    • Sadoshima, J.1    Izumo, S.2
  • 55
    • 84957442777 scopus 로고    scopus 로고
    • Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo
    • Sampson, A. K., Irvine, J. C., Shihata, W. A., Dragoljevic, D., Lumsden, N., Huet, O., et al. (2016). Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo. Br. J. Pharmacol. 173, 729–740. doi: 10.1111/bph.13063
    • (2016) Br. J. Pharmacol. , vol.173 , pp. 729-740
    • Sampson, A.K.1    Irvine, J.C.2    Shihata, W.A.3    Dragoljevic, D.4    Lumsden, N.5    Huet, O.6
  • 56
    • 84901611008 scopus 로고    scopus 로고
    • Therapeutic targets in heart failure: refocusing on the myocardial interstitium
    • Schelbert, E. B., Fonarow, G. C., Bonow, R. O., Butler, J., and Gheorghiade, M. (2014). Therapeutic targets in heart failure: refocusing on the myocardial interstitium. J. Am. Coll. Cardiol. 63, 2188–2198. doi: 10.1016/j.jacc.2014.01.068
    • (2014) J. Am. Coll. Cardiol. , vol.63 , pp. 2188-2198
    • Schelbert, E.B.1    Fonarow, G.C.2    Bonow, R.O.3    Butler, J.4    Gheorghiade, M.5
  • 57
    • 3242802874 scopus 로고    scopus 로고
    • TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing
    • Schiller, M., Javelaud, D., and Mauviel, A. (2004). TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing. J. Dermatol. Sci. 35, 83–92. doi: 10.1016/j.jdermsci.2003.12.006
    • (2004) J. Dermatol. Sci. , vol.35 , pp. 83-92
    • Schiller, M.1    Javelaud, D.2    Mauviel, A.3
  • 58
    • 0029664773 scopus 로고    scopus 로고
    • The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3′ , 5′ -monophosphate and AT1 receptormediated prostaglandin E2 production in conscious rats
    • Siragy, H.M., and Carey, R.M. (1996). The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3′ , 5′ -monophosphate and AT1 receptormediated prostaglandin E2 production in conscious rats. J. Clin. Invest. 97, 1978–1982. doi: 10.1172/JCI118630
    • (1996) J. Clin. Invest. , vol.97 , pp. 1978-1982
    • Siragy, H.M.1    Carey, R.M.2
  • 59
    • 0030610587 scopus 로고    scopus 로고
    • The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats
    • Siragy, H. M., and Carey, R. M. (1997). The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J. Clin. Invest. 100, 264–269. doi: 10.1172/JCI119531
    • (1997) J. Clin. Invest. , vol.100 , pp. 264-269
    • Siragy, H.M.1    Carey, R.M.2
  • 60
    • 84930169739 scopus 로고    scopus 로고
    • Hypertension: renin-angiotensin-aldosterone system alterations
    • Te Riet, L., van Esch, J. H., Roks, A. J., van den Meiracker, A. H., and Danser, A. H. (2015). Hypertension: renin-angiotensin-aldosterone system alterations. Circ. Res. 116, 960–975. doi: 10.1161/CIRCRESAHA.116.303587
    • (2015) Circ. Res. , vol.116 , pp. 960-975
    • Te Riet, L.1    van Esch, J.H.2    Roks, A.J.3    van den Meiracker, A.H.4    Danser, A.H.5
  • 62
    • 0029670957 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart
    • Torre-Amione, G., Kapadia, S., Lee, J., Durand, J. B., Bies, R. D., Young, J. B., et al. (1996). Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation 93, 704–711. doi: 10.1161/01.CIR.93.4.704
    • (1996) Circulation , vol.93 , pp. 704-711
    • Torre-Amione, G.1    Kapadia, S.2    Lee, J.3    Durand, J.B.4    Bies, R.D.5    Young, J.B.6
  • 63
    • 84863807562 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158,998 patients
    • van Vark, L. C., Bertrand, M., Akkerhuis, K. M., Brugts, J. J., Fox, K., Mourad, J. J., et al. (2012). Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158,998 patients. Eur. Heart J. 33, 2088–2097. doi: 10.1093/eurheartj/ehs075
    • (2012) Eur. Heart J. , vol.33 , pp. 2088-2097
    • van Vark, L.C.1    Bertrand, M.2    Akkerhuis, K.M.3    Brugts, J.J.4    Fox, K.5    Mourad, J.J.6
  • 64
    • 84865467701 scopus 로고    scopus 로고
    • Compound 21 induces vasorelaxation via an endothelium- and angiotensin II type 2 receptor-independent mechanism
    • Verdonk, K., Durik, M., Abd-Alla, N., Batenburg, W. W., van den Bogaerdt, A. J., van Veghel, R., et al. (2012). Compound 21 induces vasorelaxation via an endothelium- and angiotensin II type 2 receptor-independent mechanism. Hypertension 60, 722–729. doi: 10.1161/HYPERTENSIONAHA.112.196022
    • (2012) Hypertension , vol.60 , pp. 722-729
    • Verdonk, K.1    Durik, M.2    Abd-Alla, N.3    Batenburg, W.W.4    van den Bogaerdt, A.J.5    van Veghel, R.6
  • 65
    • 77957663006 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors (ACEIs), not angiotensin receptor blockers (ARBs), are preferred and effective mode of therapy in high cardiovascular risk patients
    • Vijan, S. G. (2009). Angiotensin-converting enzyme inhibitors (ACEIs), not angiotensin receptor blockers (ARBs), are preferred and effective mode of therapy in high cardiovascular risk patients. J. Indian Med. Assoc. 107, 178–182.
    • (2009) J. Indian Med. Assoc. , vol.107 , pp. 178-182
    • Vijan, S.G.1
  • 66
    • 8644281991 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist
    • Wan, Y., Wallinder, C., Plouffe, B., Beaudry, H., Mahalingam, A. K., Wu, X., et al. (2004). Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J. Med. Chem. 47, 5995–6008. doi: 10.1021/ jm049715t
    • (2004) J. Med. Chem. , vol.47 , pp. 5995-6008
    • Wan, Y.1    Wallinder, C.2    Plouffe, B.3    Beaudry, H.4    Mahalingam, A.K.5    Wu, X.6
  • 67
    • 0024319420 scopus 로고
    • Cardiac interstitium in health and disease: the fibrillar collagen network
    • Weber, K. T. (1989). Cardiac interstitium in health and disease: the fibrillar collagen network. J. Am. Coll. Cardiol. 13, 1637–1652. doi: 10.1016/0735-1097(89)90360-4
    • (1989) J. Am. Coll. Cardiol. , vol.13 , pp. 1637-1652
    • Weber, K.T.1
  • 68
    • 84871796377 scopus 로고    scopus 로고
    • Myofibroblast-mediated mechanisms of pathological remodelling of the heart
    • Weber, K. T., Sun, Y., Bhattacharya, S. K., Ahokas, R. A., and Gerling, I. C. (2013). Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat. Rev. Cardiol. 10, 15–26. doi: 10.1038/nrcardio.2012.158
    • (2013) Nat. Rev. Cardiol. , vol.10 , pp. 15-26
    • Weber, K.T.1    Sun, Y.2    Bhattacharya, S.K.3    Ahokas, R.A.4    Gerling, I.C.5
  • 69
    • 84878011465 scopus 로고    scopus 로고
    • Renin Inhibition and AT1R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling
    • Whaley-Connell, A., Habibi, J., Rehmer, N., Ardhanari, S., Hayden, M. R., Pulakat, L., et al. (2013). Renin Inhibition and AT1R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling. Metab. Clin. Exp. 62, 861–872. doi: 10.1016/j.metabol.2012.12.012
    • (2013) Metab. Clin. Exp. , vol.62 , pp. 861-872
    • Whaley-Connell, A.1    Habibi, J.2    Rehmer, N.3    Ardhanari, S.4    Hayden, M.R.5    Pulakat, L.6
  • 70
    • 0345304290 scopus 로고    scopus 로고
    • Angiotensin AT2 receptors: cardiovascular hope or hype
    • Widdop, R. E., Jones, E. S., Hannan, R. E., and Gaspari, T. A. (2003). Angiotensin AT2 receptors: cardiovascular hope or hype? Br. J. Pharmacol. 140, 809–824. doi: 10.1038/sj.bjp.0705448
    • (2003) Br. J. Pharmacol. , vol.140 , pp. 809-824
    • Widdop, R.E.1    Jones, E.S.2    Hannan, R.E.3    Gaspari, T.A.4
  • 71
    • 84902295269 scopus 로고    scopus 로고
    • Effects of cardiac overexpression of the angiotensin II type 2 receptor on remodeling and dysfunction in mice post-myocardial infarction
    • Xu, J., Sun, Y., Carretero, O. A., Zhu, L., Harding, P., Shesely, E. G., et al. (2014). Effects of cardiac overexpression of the angiotensin II type 2 receptor on remodeling and dysfunction in mice post-myocardial infarction. Hypertension 63, 1251–1259. doi: 10.1161/HYPERTENSIONAHA.114.03247
    • (2014) Hypertension , vol.63 , pp. 1251-1259
    • Xu, J.1    Sun, Y.2    Carretero, O.A.3    Zhu, L.4    Harding, P.5    Shesely, E.G.6
  • 72
    • 0036645586 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction
    • Yang, Z., Bove, C. M., French, B. A., Epstein, F. H., Berr, S. S., DiMaria, J. M., et al. (2002). Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction. Circulation 106, 106–111. doi: 10.1161/01.CIR.0000020014.14176.6D
    • (2002) Circulation , vol.106 , pp. 106-111
    • Yang, Z.1    Bove, C.M.2    French, B.A.3    Epstein, F.H.4    Berr, S.S.5    DiMaria, J.M.6
  • 73
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan, ramipril, or both in patients at high risk for vascular events
    • Yusuf, S., Teo, K. K., Pogue, J., Dyal, L., Copland, I., Schumacher, H., et al. (2008). Telmisartan, ramipril, or both in patients at high risk for vascular events. N. Engl. J. Med. 358, 1547–1559. doi: 10.1056/NEJMoa0801317
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1547-1559
    • Yusuf, S.1    Teo, K.K.2    Pogue, J.3    Dyal, L.4    Copland, I.5    Schumacher, H.6


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