β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats

Clinical Science

Volumn 129, Issue 6, 2015, Pages 505-513

  Del Borgo, Mark ^a   Wang, Yan ^a   Bosnyak, Sanja ^a   Khan, Morimer ^a   Walters, Pia ^a   Spizzo, Iresha ^a   Perlmutter, Patrick ^a   Hilliard, Lucinda ^a   Denton, Kate ^a   Aguilar, Marie Isabel ^a   Widdop, Robert E ^a   Jones, Emma S ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Angiotensin II type 2 (AT2) receptor; Angiotensin III; Blood pressure; Vasorelaxation; amino acid substitutions

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 2 RECEPTOR; BETA PRO7 ANGIOTENSIN III; CARDIOVASCULAR AGENT; NICOTINOYLTYROSYL(N BENZYLOXYCARBONYLARGINYL)LYSYLHISTIDYLPROLYLISOLEUCINE; UNCLASSIFIED DRUG; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN III; ANGIOTENSIN III, BETA-PRO(7)-; ANGIOTENSIN RECEPTOR; BENZIMIDAZOLE DERIVATIVE; CANDESARTAN; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; TETRAZOLE DERIVATIVE; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; EMBRYO; HUMAN; HUMAN CELL; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; VASCULAR RING; VASODILATATION; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; ANALYSIS OF VARIANCE; ANIMAL; BINDING COMPETITION; BLOOD; CHEMISTRY; DRUG EFFECTS; DRUG STABILITY; HEK293 CELL LINE; HYPERTENSION; IC50; IN VITRO STUDY; MALE; METABOLISM; MUSCLE ISOMETRIC CONTRACTION; PATHOPHYSIOLOGY; THORACIC AORTA; VASCULAR SMOOTH MUSCLE;

AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANGIOTENSIN II TYPE 2 RECEPTOR BLOCKERS; ANGIOTENSIN III; ANIMALS; AORTA, THORACIC; BENZIMIDAZOLES; BINDING, COMPETITIVE; DRUG STABILITY; HEK293 CELLS; HUMANS; HYPERTENSION; IMIDAZOLES; IN VITRO TECHNIQUES; INHIBITORY CONCENTRATION 50; ISOMETRIC CONTRACTION; MALE; MICE; MUSCLE, SMOOTH, VASCULAR; PYRIDINES; RATS; RECEPTORS, ANGIOTENSIN; TETRAZOLES; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 84942809272     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20150077     Document Type: Article

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