Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment

Cell Reports

Volumn 19, Issue 8, 2017, Pages 1503-1511

  Kirschner, Kristina ^a,b,c   Chandra, Tamir ^d,e   Kiselev, Vladimir ^f   Flores Santa Cruz, David ^a   Macaulay, Iain C ^f   Park, Hyun Jun ^a   Li, Juan ^a   Kent, David G ^a   Kumar, Rupa ^a   Pask, Dean C ^a   Hamilton, Tina L ^a   Hemberg, Martin ^f   Reik, Wolf ^d,f   Green, Anthony R ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d BABRAHAM INSTITUTE   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

aging; cancer; cellular aging; genomics; hematology; JAK2; leukemia; p53; scRNA seq; stem cells

Indexed keywords

JANUS KINASE; JANUS KINASE 2; PROTEIN P53; STAT PROTEIN; JAK2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL AGING; CELL EXPANSION; CELL HETEROGENEITY; CELL PROLIFERATION; CELL SUBPOPULATION; CONTROLLED STUDY; ENZYME ACTIVATION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; ANIMAL; BONE MARROW CELL; CELL COMPARTMENTALIZATION; CELL CYCLE; CYTOLOGY; METABOLISM;

ANIMALS; CELL COMPARTMENTATION; CELL CYCLE; CELL PROLIFERATION; CELLULAR SENESCENCE; HEMATOPOIETIC STEM CELLS; JANUS KINASE 2; MICE; MYELOID CELLS; TRANSCRIPTION FACTORS;

EID: 85019709160     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.04.074     Document Type: Article

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