Anthocyanin pharmacokinetics and dose-dependent plasma antioxidant pharmacodynamics following whole tart cherry intake in healthy humans

Journal of Functional Foods

Volumn 11, Issue C, 2014, Pages 509-516

  Seymour, E Mitchell ^a   Warber, Sara M ^b   Kirakosyan, Ara ^a   Noon, Kathleen R ^c   Gillespie, Brenda ^b   Uhley, Virginia E ^d   Wunder, Jenna ^b   Urcuyo, Daniel E ^e   Kaufman, Peter B ^a   Bolling, Steven F ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d OAKLAND UNIVERSITY WILLIAM BEAUMONT SCHOOL OF MEDICINE   (United States)

^e CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

Author keywords

Anthocyanins; Antioxidant; Pharmacokinetics; Tart cherry

Indexed keywords

PRUNUS CERASUS;

EID: 85027924159     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2014.08.007     Document Type: Article

References (27)

1. Bell P.G., Walshe I.H., Davison G.W., Stevenson E., Howatson G. Montmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cycling. Nutrients 2014, 6(2):829-843. 10.3390/nu6020829.
2. Burton-Freeman B. Postprandial metabolic events and fruit-derived phenolics: A review of the science. The British Journal of Nutrition 2010, 104(Suppl. 3):S1-S14. 10.1017/S0007114510003909.
3. Cao G., Muccitelli H.U., Sanchez-Moreno C., Prior R.L. Anthocyanins are absorbed in glycated forms in elderly women: A pharmacokinetic study. The American Journal of Clinical Nutrition 2001, 73(5):920-926.
4. Carkeet C., Clevidence B.A., Novotny J.A. Anthocyanin excretion by humans increases linearly with increasing strawberry dose. The Journal of Nutrition 2008, 138(5):897-902.
5. Ceriello A., Taboga C., Tonutti L., Quagliaro L., Piconi L., Bais B., Da Ros R., Motz E. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: Effects of short- and long-term simvastatin treatment. Circulation 2002, 106(10):1211-1218.
6. de Ferrars R.M., Czank C., Zhang Q., Botting N.P., Kroon P.A., Cassidy A., Kay C.D. The pharmacokinetics of anthocyanins and their metabolites in humans. British Journal of Pharmacology 2014, 171(13):3268-3282. 10.1111/bph.12676.
7. Felgines C., Talavera S., Gonthier M.P., Texier O., Scalbert A., Lamaison J.L., Remesy C. Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans. The Journal of Nutrition 2003, 133(5):1296-1301.
8. Felgines C., Talavera S., Texier O., Gil-Izquierdo A., Lamaison J.L., Remesy C. Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans. Journal of Agricultural and Food Chemistry 2005, 53(20):7721-7727. 10.1021/jf051092k.
9. Hollands W., Brett G.M., Dainty J.R., Teucher B., Kroon P.A. Urinary excretion of strawberry anthocyanins is dose dependent for physiological oral doses of fresh fruit. Molecular Nutrition & Food Research 2008, 52(10):1097-1105. 10.1002/mnfr.200700372.
10. Howatson G., McHugh M.P., Hill J.A., Brouner J., Jewell A.P., van Someren K.A., Shave R.E., Howatson S.A. Influence of tart cherry juice on indices of recovery following marathon running. Scandinavian Journal of Medicine and Science in Sports 2010, 20(6):843-852. 10.1111/j.1600-0838.2009.01005.x.
11. Kay C.D., Mazza G., Holub B.J., Wang J. Anthocyanin metabolites in human urine and serum. The British Journal of Nutrition 2004, 91(6):933-942.
12. Kim D.O., Heo H.J., Kim Y.J., Yang H.S., Lee C.Y. Sweet and sour cherry phenolics and their protective effects on neuronal cells. Journal of Agricultural and Food Chemistry 2005, 53(26):9921-9927. 10.1021/jf0518599.
13. Kirakosyan A., Seymour E.M., Llanes D.E.U., Kaufman P.B., Bolling S.F. Chemical profile and antioxidant capacities of tart cherry products. Food Chemistry 2009, 115(1):20-25.
14. Lynn A., Mathew S., Moore C.T., Russell J., Robinson E., Soumpasi V., Barker M.E. Effect of a tart cherry juice supplement on arterial stiffness and inflammation in healthy adults: A randomised controlled trial. Plant Foods for Human Nutrition 2014, 69(2):122-127. 10.1007/s11130-014-0409-x.
15. Matchynski J.J., Lowrance S.A., Pappas C., Rossignol J., Puckett N., Sandstrom M., Dunbar G.L. Combinatorial treatment of tart cherry extract and essential fatty acids reduces cognitive impairments and inflammation in the mu-p75 saporin-induced mouse model of Alzheimer's disease. Journal of Medicinal Food 2013, 16(4):288-295. 10.1089/jmf.2012.0131.
16. McGhie T.K., Ainge G.D., Barnett L.E., Cooney J.M., Jensen D.J. Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolized by both humans and rats. Journal of Agricultural and Food Chemistry 2003, 51(16):4539-4548. 10.1021/jf026206w.
17. Mertens-Talcott S.U., Rios J., Jilma-Stohlawetz P., Pacheco-Palencia L.A., Meibohm B., Talcott S.T., Derendorf H. Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers. Journal of Agricultural and Food Chemistry 2008, 56(17):7796-7802. 10.1021/jf8007037.
18. Mink P.J., Scrafford C.G., Barraj L.M., Harnack L., Hong C.P., Nettleton J.A., Jacobs D.R. Flavonoid intake and cardiovascular disease mortality: A prospective study in postmenopausal women. The American Journal of Clinical Nutrition 2007, 85(3):895-909.
19. Ou B., Bosak K.N., Brickner P.R., Iezzoni D.G., Seymour E.M. Processed tart cherry products - Comparative phytochemical content, in vitro antioxidant capacity and in vitro anti-inflammatory activity. Journal of Food Science 2012, 77(5):H105-H112. 10.1111/j.1750-3841.2012.02681.x.
20. Prior R.L., Gu L., Wu X., Jacob R.A., Sotoudeh G., Kader A.A., Cook R.A. Plasma antioxidant capacity changes following a meal as a measure of the ability of a food to alter in vivo antioxidant status. Journal of the American College of Nutrition 2007, 26(2):170-181.
21. Prior R.L., Wu X., Schaich K. Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. Journal of Agricultural and Food Chemistry 2005, 53(10):4290-4302. 10.1021/jf0502698.
22. Schumacher H.R., Pullman-Mooar S., Gupta S.R., Dinnella J.E., Kim R., McHugh M.P. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis and Cartilage/OARS, Osteoarthritis Research Society 2013, 21(8):1035-1041. 10.1016/j.joca.2013.05.009.
23. Seymour E.M., Lewis S.K., Urcuyo-Llanes D.E., Tanone I.I., Kirakosyan A., Kaufman P.B., Bolling S.F. Regular tart cherry intake alters abdominal adiposity, adipose gene transcription, and inflammation in obesity-prone rats fed a high fat diet. Journal of Medicinal Food 2009, 12(5):935-942. 10.1089/jmf.2008.0270.
24. Tall J.M., Seeram N.P., Zhao C., Nair M.G., Meyer R.A., Raja S.N. Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Behavioural Brain Research 2004, 153(1):181-188. 10.1016/j.bbr.2003.11.011.
25. Traustadottir T., Davies S.S., Stock A.A., Su Y., Heward C.B., Roberts L.J., Harman S.M. Tart cherry juice decreases oxidative stress in healthy older men and women. The Journal of Nutrition 2009, 139(10):1896-1900. 10.3945/jn.109.111716.
26. Wautier J.L., Boulanger E., Wautier M.P. Postprandial hyperglycemia alters inflammatory and hemostatic parameters. Diabetes and Metabolism 2006, 32(Spec No 2). 2S34-2S36.
27. Wu X., Cao G., Prior R.L. Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry. The Journal of Nutrition 2002, 132(7):1865-1871.