Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Blood

Volumn 130, Issue 12, 2017, Pages 1445-1455

  Madhusudhan, Thati ^a,b   Wang, Hongjie ^a,c   Ghosh, Sanchita ^a   Dong, Wei ^a,d   Kumar, Varun ^e   Al Dabet, Moh’d Mohanad ^a   Manoharan, Jayakumar ^a   Nazir, Sumra ^a   Elwakiel, Ahmed ^a   Bock, Fabian ^a,f   Kohli, Shrey ^a   Marquardt, Andi ^a   Sögüt, Ibrahim ^a,g   Shahzad, Khurrum ^a,h   Müller, Andreas J ^a,i   Esmon, Charles T ^j   Nawroth, Peter P ^e   Reiser, Jochen ^k   Chavakis, Triantafyllos ^l   Ruf, Wolfram ^b,m   Isermann, Berend ^a   more..

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^g ISTANBUL BILIM UNIVERSITY   (Turkey)

^h UNIVERSITY OF SARGODHA   (Pakistan)

ⁱ HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^j UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^k RUSH MEDICAL COLLEGE   (United States)

^l DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^m SCRIPPS RESEARCH INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C; PROTEIN P85; PROTEIN P85ALPHA; PROTEIN P85BETA; THROMBOMODULIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; PEPTIDE HYDROLASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; THBD PROTEIN, MOUSE; XBP1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENE MAPPING; GENE TARGETING; GENOME; HOMEOSTASIS; HUMAN; HUMAN CELL; INSULIN SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UNFOLDED PROTEIN RESPONSE; ANIMAL; BIOLOGICAL MODEL; BLOOD CLOTTING; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ANIMALS; BLOOD COAGULATION; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; DIABETIC NEPHROPATHIES; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; INSULIN; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PEPTIDE HYDROLASES; PROTEIN C; SIGNAL TRANSDUCTION; THROMBOMODULIN; UNFOLDED PROTEIN RESPONSE; X-BOX BINDING PROTEIN 1;

EID: 85027712509     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2017-02-767921     Document Type: Article

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