Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation

Thrombosis Research

Volumn 115, Issue 4, 2005, Pages 319-325

  Yamaji, Kazuyo ^a,b   Wang, Yin ^a,c   Liu, Yan ^a,c   Abeyama, Kazuhiro ^a   Hashiguchi, Teruto ^a   Uchimura, Tomonori ^a   Krishna Biswas, Kamal ^a   Iwamoto, Hisahiko ^d   Maruyama, Ikuro ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d Dept of R and D for Diagnostics   (Japan)

Author keywords

Activated protein C; Advanced glycation end products; Lipid peroxidation; Reactive oxygen species

Indexed keywords

ACTIVATED PROTEIN C; THROMBIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CELL ACTIVATION; CELL PROTECTION; CONTROLLED STUDY; DIABETES MELLITUS; GLYCATION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MACROPHAGE; PRIORITY JOURNAL;

ANIMALS; ANTICOAGULANTS; ANTIOXIDANTS; CELL LINE; CELL-FREE SYSTEM; COPPER; CYTOKINES; GLYCOSYLATION END PRODUCTS, ADVANCED; INFLAMMATION MEDIATORS; INTERLEUKIN-1; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; LIPOPROTEINS, LDL; MICE; NF-KAPPA B; PROTEIN C; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 12544253819     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2004.09.011     Document Type: Article

References (31)

1. K. Murakami, K. Okajima, M. Uchida, M. Johno, T. Nakagaki, and H. Okabe Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production Am. J. Physiol. 27 1997 L197 L202
2. S.T. Grey, A. Tsuchida, H. Hau, C.L. Orthner, H.H. Salem, and W.W. Hancock Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester J. Immunol. 153 1994 3664 3672
3. B. White, M. Schmidt, C. Murphy, W. Livingstone, D. O'Toole, and M. Lawler Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line Br. J. Haematol. 110 2000 130 134
4. D.E. Joyce, L. Gelbert, A. Ciaccia, B. DeHoff, and B.W. Grinnell Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis J. Biol. Chem. 276 2001 11199 11203
5. S.D. Yan, A.M. Schmidt, G.M. Anderson, J. Zhang, J. Brett, and Y.S. Zou Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins J. Biol. Chem. 269 1994 9889 9897
6. D.A. Bass, J.W. Parce, L.R. Dechatelet, P. Szejda, M.C. Seeds, and M. Thomas Flow cytometric studies of oxidative product formation by neutrophils: a granded response to membrane stimulation J. Immunol. 130 1983 1910 1917
7. I. Kitajima, T. Shinohara, J. Bilakovics, D.A. Brown, X. Xu, and M. Nerenberg Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B Science 258 1992 1792 1795
8. J.A. Buege, and S.D. Aust Microsomal lipid peroxidation Methods Enzymol. 52 1978 302 310
9. T. Uchimura, K. Nakano, T. Hashiguchi, H. Iwamoto, K. Miura, and Y. Yoshimura Elevation of N-(carboxymethyl)valine residue in hemoglobin of diabetic patients. Its role in the development of diabetic nephropathy Diabetes Care 24 2001 891 896
10. U. Pattanaik, and K. Prasad Endotoxiemia and oxidative stress Ann. N.Y. Acad. Sci. 793 1996 506 510
11. J. Yao, N. Mackman, T.S. Edgington, and S.T. Fan Lipopolysaccharide induction of the tumor necrosis factor-α promoter in human monocytic cells: regulation by Egr-1, c-Jun, and NF-κB transcription factors J. Biol. Chem. 272 1997 17795 17801
12. S.L. Weinstein, M.R. Gold, and A.L. DeFranco Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages Proc. Natl. Acad. Sci. U. S. A. 88 1991 4148 4152
13. H.Y. Hsu, and M.H. Wen Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression J. Biol. Chem. 277 2002 22131 22139
14. N.R. Harris, J.M. Russell, and D.N. Granger Mediators of endotoxin-induced leukocyte adhesion in mesenteric postcapillary venules Circ. Shock 43 4 1994 155 160
15. W.H. Cerwinka, D. Cooper, C.F. Krieglstein, C.R. Ross, J.M. McCord, and D.N. Granger Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules Am. J. Physiol., Heart Circ. Physol. 284 2003 H535 H541
16. F. Shu, H. Kobayashi, K. Fukudome, N. Tsuneyoshi, M. Kimoto, and T. Terao Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner FEBS Lett. 477 2000 208 212
17. T. Cheng, D. Liu, J.H. Griffin, J.A. Fernandez, F. Castellino, and E.D. Rosen Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nat. Med. 9 2003 338 342
18. F.B.J. Taylor, D.J. Stearns-Kurosawa, S. Kurosawa, G. Ferrell, A.C. Chang, and Z. Laszik The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis Blood 95 2000 1680 1686
19. M. Yuksel, K. Okajima, M. Uchiba, S. Horiuchi, and H. Okabe Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes Thromb. Haemost. 88 2002 267 273
20. J. Raingeaud, S. Gupta, J.S. Rogers, M. Dickens, J. Han, and R.J. Ulevitch Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine J. Biol. Chem. 270 1995 7420 7426
21. D. Callsen, and B. Brune Role of mitogen-activated protein kinases in S-nitrosoglutathione-induced macrophage apoptosis Biochemistry 38 1999 2279 2286
22. A. Gruber, and J.H. Griffin Direct detection of activated protein C in blood from human subjects Blood 79 1992 2340 2348
23. S.M. Opal, P.J. Scannon, J.L. Vincent, M. White, S.F. Carroll, and J.E. Palardy Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock J. Infect. Dis. 180 1999 1584 1589
24. J.L. Witztum, and D. Steinberg Role of oxidized low density lipoprotein in atherogenesis J. Clin. Invest. 88 1991 1785 1792
25. J.F.J. Keaney, D.I. Simon, and J.E. Freedman Vitamin E and vascular homeostasis: implications for atherosclerosis FASEB J. 13 1999 965 975
26. V.M. Monnier, D.R. Sell, R.H. Nagaraj, S. Miyata, S. Grandhee, and P. Odetti Maillard reaction-mediated molecular damage to extracellular matrix and other tissue proteins in diabetes, aging, and uremia Diabetes 41 1992 36 41
27. J.W. Baynes Role of oxidative stress in development of complications in diabetes Diabetes 40 1991 405 412
28. M.X. Fu, J.R. Requena, A.J. Jenkins, T.J. Lyons, J.W. Baynes, and S.R. Thorpe The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions J. Biol. Chem. 271 1996 9982 9986
29. R. Shapiro, M.J. McManus, C. Zalut, and H.F. Bunn Sites of nonenzymatic glycosylation of human hemoglobin A J. Biol. Chem. 255 1980 3120 3127
30. F.W. Miriam, A.R. Roger, C.J. Amy, and E.H. Donald Free pentosidine and neoptarin as markers of progression rate in diabetic nephropathy Kidney Int. 54 1998 193 202
31. M. Portero-Otin, R.H. Nagaraj, and V.M. Monnier Chromatographic evidence for pyrraline formation during protein glycation in vitro and in vivo Biochim. Biophys. Acta 1247 1995 74 80