Activated protein C prevents methylglyoxal-induced endoplasmic reticulum stress and cardiomyocyte apoptosis via regulation of the AMP-activated protein kinase signaling pathway

Biochemical and Biophysical Research Communications

Volumn 480, Issue 4, 2016, Pages 622-628

  Nam, Dae Hwan ^a   Han, Jung Hwa ^a   Kim, Suji ^a   Shin, YoungHyun ^b   Lim, Jae Hyang ^c   Choi, Hyoung Chul ^a   Woo, Chang Hoon ^a  

^a Yeungnam University College of Medicine   (South Korea)

^b Korea National Institute of Health   (South Korea)

^c Ewha Womans University School of Medicine   (South Korea)

Author keywords

AMPK; APC; Cardiomyocyte; CHOP; ER stress; Methylglyoxal

Indexed keywords

ACTIVATED PROTEIN C; CALCIUM ION; CYTOPROTECTIVE AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; METHYLGLYOXAL; PROTEIN SERINE THREONINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; CARDIOTONIC AGENT; PROTEIN C;

ADENOVIRIDAE; ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CARDIAC MUSCLE CELL; CELL PROTECTION; DIABETIC CARDIOMYOPATHY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION; HEART PROTECTION; MOUSE; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; PHYSIOLOGY;

AMP-ACTIVATED PROTEIN KINASES; APOPTOSIS; CARDIOTONIC AGENTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; HUMANS; MYOCYTES, CARDIAC; PROTEIN C; PYRUVALDEHYDE; SIGNAL TRANSDUCTION;

EID: 84994527514     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.10.106     Document Type: Article

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