PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 33, 2017, Pages E6902-E6911

  Liu, Yonghong ^a   Qu, Linlin ^a   Liu, Yuanyuan ^a   Roizman, Bernard ^b,c   Zhou, Grace Guoying ^a,b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b Shenzhen Investigation and Research Institute   (China)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Interferon; LGP2; MDA5; PUM1; RIG I

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HISTONE DEACETYLASE 4; ICP 27 PROTEIN; IFIT 1 PROTEIN; INFECTED CELL PROTEIN 8; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; INTERLEUKIN 16; INTERLEUKIN 6; LGP 2 PROTEIN; MESSENGER RNA; NUCLEAR FACTOR KAPPA B1; PEPTIDES AND PROTEINS; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN KINASE R; PROTEIN VP16; PUMILIO PROTEIN 1; RETINOIC ACID INDUCIBLE PROTEIN I; RNA 18S; RNA BINDING PROTEIN; SMALL INTERFERING RNA; SP 100 PROTEIN; STING PROTEIN; UL 42 PROTEIN; UNCLASSIFIED DRUG; DHX58 PROTEIN, HUMAN; PUM1 PROTEIN, HUMAN; RNA HELICASE;

ARTICLE; BINDING SITE; CONSERVED SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSFECTION; HEP-2 CELL LINE; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REPRESSOR GENE; RNA-BINDING DOMAIN; SYNTHESIS; TRANSLATION INITIATION; UPREGULATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RNA INTERFERENCE; TUMOR CELL LINE;

CELL LINE, TUMOR; CHEMOKINE CXCL10; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERFERON-BETA; INTERLEUKIN-6; RNA HELICASES; RNA INTERFERENCE; RNA-BINDING PROTEINS;

EID: 85027415632     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1708713114     Document Type: Article

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