The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins

RNA

Volumn 3, Issue 12, 1997, Pages 1421-1433

  Zamore, Phillip D ^a   Williamson, James R ^a   Lehmann, Ruth ^b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Drosophila melanogaster; Hunchback mRNA; Nanos Response Element (NRE); Pumilio (PUM); Pumilio Homology Domain (PUM HD); RNA binding proteins; Translational regulation

Indexed keywords

MESSENGER RNA; RNA BINDING PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN RNA BINDING; TRANSLATION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BIOSYNTHESIS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TRANSCRIPTION FACTORS;

ANIMALIA; DROSOPHILA MELANOGASTER; FUNGI; MELANOGASTER;

EID: 0031440357     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Ahringer J. Kimble J. 1991. Control of the sperm-oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3′ untranslated region. Nature 349:346-348.
2. Ahringer J, Rosenquist TA, Lawson DN, Kimble J. 1992. The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally. EMBO J 11:2303-2310.
3. Barker DD, Wang C, Moore J, Dickinson LK, Lehmann R. 1992. Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos. Genes & Dev 6:2312-2326.
4. Chen W, Balzi E, Capieaux E, Goffeau A. 1991. The YGL023 gene encodes a putative regulatory protein. Yeast 7:309-312.
5. Curtis D, Lehmann R, Zamore P. 1995. Translational regulation in development. Cell 81:171-178.
6. Curtis D, Treiber DK, Tao F, Zamore PD, Williamson JR, Lehmann R. 1997. A CCHC metal-binding domain in Nanos is essential for translational regulation. EMBO J 16:834-843.
7. Dalby B, Glover DM. 1993. Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila. EMBO J 12:1219-1227.
8. Dubnau J, Struhl G. 1996. RNA recognition and translational regulation by a homeodomain protein. Nature 379:694-699.
9. Evans TC, Crittenden SL, Kodoyianni V, Kimble J. 1994. Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo. Cell 77:183-194.
10. Gavis ER, Lehmann R. 1992. Localization of manos RNA controls embryonic polarity Cell 71:301-313.
11. Goodwin EB, Okkema PG, Evans TC, Kimble J. 1993. Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans. Cell 75:329-339.
12. Hülskamp M, Pfeifle C, Tautz D. 1990. A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo. Nature 346:577-580.
13. Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM, Guarente L. 1997. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89:381-391.
14. Lee RC, Feinbaum RL, Ambros V. 1991. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843-854.
15. Lehmann R, Nüsslein-Valhard C. 1987. Involvement of the pumilio gene in the transport of an abdominal signal in the Drosophila embryo. Nature 329:167-170.
16. Lehmann R, Nüsslein-Volhard C. 1991. The maternal gene nanos has a central role in posterior pattern formation of the Drosophila embryo. Development 112:679-691.
17. Macdonald PM. 1992. The Drosophila pumilio gene: An unusually long transcription unit and an unusual protein. Development 114:221-232.
18. Mlodzik M, Gehring WJ. 1987. Expression of the caudal gene in the germ line of Drosophila: Formation of an RNA and protein gradient during early embryogenesis. Cell 48:465-478.
19. Moss EG, Lee RC, Ambros V. 1997. The cold shock domain protein LIN-28 controls development timing in C. elegans and is regulated by the lin-4 RNA. Cell 88:637-646.
20. Murata Y, Wharton RP. 1995. Binding of Pumilio to materinal hunchembryos. Cell 80:747-756.
21. Rivera-Pomar R, Lu X, Perrimon N, Taubert H, Jäckle H. 1995. Activation of posterior gap gene expression in the Drosophila blastoderm. Nature 376:253-256.
22. St Johnston D, Nüsslein-Volhard C. 1992. The origin of pattern and polarity in the Drosophila embryo. Cell 68:201-219.
23. Tautz D, Lehmann R, Schnurch H, Schuh R, Seifert E, Kienlin A, Jones K, Jäckle H. 1987. Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes. Nature 327:383-389.
24. Tautz D, Pfeifle C. 1989. A non-radioactive in situ hybridization Method for the localization of specific RNAs in Drosophila embroyos reveals translational control of the segmentation gene hunchback Chromosoma 98:81-85.
25. Wang C, Dickinson LK, Lehmann R. 1994. The genetics of nanos localization in Drosophila. Developmental Dynamics 199:103-115.
26. Wang C, Lehmann R. 1991. Nanos is the localized posterior determinant in Drosophila. Cell 66:637-648.
27. Wharton RP, Struhl, G. 1991. RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos. Cell 67:955-697.
28. Wickens M, Kimble J, Strickland S. 1996. Translational control of developmental decisions. In: Hershey JWB, Mathews MB, Sonenberg N, eds. Translational control. Plainview, New York: Cold Spring Harbor Laboratory Press. pp 411-450.
29. Wightman B, Ha I, Ruvkun G. 1993. Posttranscriptinal regulation of the heterochronic gene lin-14 by lin-4 mediates temporal patten formation in C. elegans. Cell 75:855-862.
30. Wreden C, Verrotti AC, Schisa JA, Lieberfard ME, Strickland S. 1997. Nanos and pumilio estabilish embryonic polarity in Drosophila by promoting posterior deadenylation of lunchback mRNA. Development 124:3015-3023.
31. Zhang B, Gallegos M, Puoti A, Durkin E, Fields S, Kimble J, Wickens MP, FBF, a conserved RNA binding protein that regulates patterning of sexual fates in the C. elegans hermaphrodite germline. Nature, in press.