-
1
-
-
84879028884
-
Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes
-
Koon HW, Shih DQ, Hing TC, Yoo JH, Ho S, Chen X, Kelly CP, Targan SR, Pothoulakis C. 2013. Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes. Antimicrob Agents Chemother 57:3214–3223. https://doi.org/10.1128/AAC.02633-12.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 3214-3223
-
-
Koon, H.W.1
Shih, D.Q.2
Hing, T.C.3
Yoo, J.H.4
Ho, S.5
Chen, X.6
Kelly, C.P.7
Targan, S.R.8
Pothoulakis, C.9
-
2
-
-
77954848009
-
The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives
-
Carter GP, Rood JI, Lyras D. 2010. The role of toxin A and toxin B in Clostridium difficile-associated disease: past and present perspectives. Gut Microbes 1:58–64. https://doi.org/10.4161/gmic.1.1.10768.
-
(2010)
Gut Microbes
, vol.1
, pp. 58-64
-
-
Carter, G.P.1
Rood, J.I.2
Lyras, D.3
-
3
-
-
67649391053
-
Clostridium difficile infection: New developments in epidemiology and pathogenesis
-
Rupnik M, Wilcox MH, Gerding DN. 2009. Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol 7:526–536. https://doi.org/10.1038/nrmicro2164.
-
(2009)
Nat Rev Microbiol
, vol.7
, pp. 526-536
-
-
Rupnik, M.1
Wilcox, M.H.2
Gerding, D.N.3
-
4
-
-
84876160855
-
Effect of host defenses on Clostridium difficile toxin-induced intestinal barrier injury
-
Olson A, Diebel LN, Liberati DM. 2013. Effect of host defenses on Clostridium difficile toxin-induced intestinal barrier injury. J Trauma Acute Care Surg 74:983–989. https://doi.org/10.1097/TA.0b013e3182858477.
-
(2013)
J Trauma Acute Care Surg
, vol.74
, pp. 983-989
-
-
Olson, A.1
Diebel, L.N.2
Liberati, D.M.3
-
5
-
-
84890821186
-
Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis
-
Madan R, Guo X, Naylor C, Buonomo EL, Mackay D, Noor Z, Concannon P, Scully KW, Pramoonjago P, Kolling GL, Warren CA, Duggal P, Petri WA, Jr. 2014. Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis. Infect Immun 82:341–349. https://doi.org/10.1128/IAI.00972-13.
-
(2014)
Infect Immun
, vol.82
, pp. 341-349
-
-
Madan, R.1
Guo, X.2
Naylor, C.3
Buonomo, E.L.4
Mackay, D.5
Noor, Z.6
Concannon, P.7
Scully, K.W.8
Pramoonjago, P.9
Kolling, G.L.10
Warren, C.A.11
Duggal, P.12
Petri, W.A.13
-
6
-
-
79960420811
-
The host immune response to Clostridium difficile
-
Kelly CP, Kyne L. 2011. The host immune response to Clostridium difficile. J Med Microbiol 60:1070–1079. https://doi.org/10.1099/jmm.0.030015-0.
-
(2011)
J Med Microbiol
, vol.60
, pp. 1070-1079
-
-
Kelly, C.P.1
Kyne, L.2
-
7
-
-
84878317467
-
Markers of intestinal inflammation, not bacterial burden, correlate with clinical outcomes in Clostridium difficile infection
-
El Feghaly RE, Stauber JL, Deych E, Gonzalez C, Tarr PI, Haslam DB. 2013. Markers of intestinal inflammation, not bacterial burden, correlate with clinical outcomes in Clostridium difficile infection. Clin Infect Dis 56: 1713–1721. https://doi.org/10.1093/cid/cit147.
-
(2013)
Clin Infect Dis
, vol.56
, pp. 1713-1721
-
-
El Feghaly, R.E.1
Stauber, J.L.2
Deych, E.3
Gonzalez, C.4
Tarr, P.I.5
Haslam, D.B.6
-
8
-
-
28844442756
-
Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase
-
Kim H, Kokkotou E, Na X, Rhee SH, Moyer MP, Pothoulakis C, Lamont JT. 2005. Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology 129:1875–1888. https://doi.org/10 .1053/j.gastro.2005.09.011.
-
(2005)
Gastroenterology
, vol.129
, pp. 1875-1888
-
-
Kim, H.1
Kokkotou, E.2
Na, X.3
Rhee, S.H.4
Moyer, M.P.5
Pothoulakis, C.6
Lamont, J.T.7
-
9
-
-
84867598881
-
Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strains
-
Theriot CM, Koumpouras CC, Carlson PE, Bergin II, Aronoff DM, Young VB. 2011. Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strains. Gut Microbes 2:326–234. https://doi.org/10.4161/gmic.19142.
-
(2011)
Gut Microbes
, vol.2
, pp. 326-1234
-
-
Theriot, C.M.1
Koumpouras, C.C.2
Carlson, P.E.3
Bergin, I.I.4
Aronoff, D.M.5
Young, V.B.6
-
10
-
-
77951026738
-
Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
-
Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, Pepin J, Wilcox MH. 2010. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Contrl Hosp Epidemiol 31:431– 455. https://doi.org/10.1086/651706.
-
(2010)
Infect Contrl Hosp Epidemiol
, vol.31
, pp. 431-455
-
-
Cohen, S.H.1
Gerding, D.N.2
Johnson, S.3
Kelly, C.P.4
Loo, V.G.5
McDonald, L.C.6
Pepin, J.7
Wilcox, M.H.8
-
11
-
-
34547133720
-
A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity
-
Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. 2007. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis 45: 302–307. https://doi.org/10.1086/519265.
-
(2007)
Clin Infect Dis
, vol.45
, pp. 302-307
-
-
Zar, F.A.1
Bakkanagari, S.R.2
Moorthi, K.M.3
Davis, M.B.4
-
12
-
-
80055115172
-
Antibiotic treatment for Clostridium difficile-associated diarrhea in adults
-
Nelson RL, Kelsey P, Leeman H, Meardon N, Patel H, Paul K, Rees R, Taylor B, Wood E, Malakun R. 2011. Antibiotic treatment for Clostridium difficile-associated diarrhea in adults. Cochrane Database Syst Rev 9:CD004610.
-
(2011)
Cochrane Database Syst Rev
, vol.9
, pp. CD004610
-
-
Nelson, R.L.1
Kelsey, P.2
Leeman, H.3
Meardon, N.4
Patel, H.5
Paul, K.6
Rees, R.7
Taylor, B.8
Wood, E.9
Malakun, R.10
-
13
-
-
19344364596
-
Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole
-
Musher DM, Aslam S, Logan N, Nallacheru S, Bhaila I, Borchert F, Hamill RJ. 2005. Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole. Clin Infect Dis 40:1586–1590. https://doi.org/10.1086/430311.
-
(2005)
Clin Infect Dis
, vol.40
, pp. 1586-1590
-
-
Musher, D.M.1
Aslam, S.2
Logan, N.3
Nallacheru, S.4
Bhaila, I.5
Borchert, F.6
Hamill, R.J.7
-
14
-
-
84908399534
-
The role of local systemic cytokines in patients infected with Clostridium difficile
-
Czepiel J, Biesiada G, Brzozowski T, Ptak-Belowska A, Perucki W, Birczynska M, Jurczyszyn A, Strzalka M, Targosz A, Garlicki A. 2014. The role of local systemic cytokines in patients infected with Clostridium difficile. J Physiol Pharmacol 65:695–703.
-
(2014)
J Physiol Pharmacol
, vol.65
, pp. 695-703
-
-
Czepiel, J.1
Biesiada, G.2
Brzozowski, T.3
Ptak-Belowska, A.4
Perucki, W.5
Birczynska, M.6
Jurczyszyn, A.7
Strzalka, M.8
Targosz, A.9
Garlicki, A.10
-
15
-
-
84924181912
-
Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile
-
Cowardin CA, Kuehne SA, Buonomo EL, Marie CS, Minton NP, Petri WA, Jr. 2015. Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile. mBio 6:e02386-14. https://doi.org/10.1128/mBio.02386-14.
-
(2015)
Mbio
, vol.6
, pp. e02386-e02414
-
-
Cowardin, C.A.1
Kuehne, S.A.2
Buonomo, E.L.3
Marie, C.S.4
Minton, N.P.5
Petri, W.A.6
-
16
-
-
36849012986
-
Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A
-
Lee JY, Park HR, Oh YK, Kim YJ, Youn J, Han JS, Kim JM. 2007. Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A. J Mol Med 85: 1393–1404. https://doi.org/10.1007/s00109-007-0237-7.
-
(2007)
J Mol Med
, vol.85
, pp. 1393-1404
-
-
Lee, J.Y.1
Park, H.R.2
Oh, Y.K.3
Kim, Y.J.4
Youn, J.5
Han, J.S.6
Kim, J.M.7
-
17
-
-
0034049140
-
P38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
-
Warny M, Keates AC, Keates S, Castagliuolo I, Zacks JK, Aboudola S, Qaman A, Pothoulakis C, LaMont JT, Kelly CP. 2000. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. J Clin Investig 105:1147–1156. https://doi.org/10.1172/JCI7545.
-
(2000)
J Clin Investig
, vol.105
, pp. 1147-1156
-
-
Warny, M.1
Keates, A.C.2
Keates, S.3
Castagliuolo, I.4
Zacks, J.K.5
Aboudola, S.6
Qaman, A.7
Pothoulakis, C.8
LaMont, J.T.9
Kelly, C.P.10
-
18
-
-
0033571379
-
Roles of intracellular calcium and NF-kappa B in the Clostridium difficile toxin A-induced upregulation and secretion of IL-8 from human monocytes
-
Jefferson KK, Smith MF, Jr, Bobak DA. 1999. Roles of intracellular calcium and NF-kappa B in the Clostridium difficile toxin A-induced upregulation and secretion of IL-8 from human monocytes. J Immunol 163:5183–5191.
-
(1999)
J Immunol
, vol.163
, pp. 5183-5191
-
-
Jefferson, K.K.1
Smith, M.F.2
Bobak, D.A.3
-
19
-
-
33745536745
-
NF-kappa B activation pathway is essential for the chemokine expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A
-
Kim JM, Lee JY, Yoon YM, Oh YK, Youn J, Kim YJ. 2006. NF-kappa B activation pathway is essential for the chemokine expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A. Scand J Immunol 63: 453– 460. https://doi.org/10.1111/j.1365-3083.2006.001756.x.
-
(2006)
Scand J Immunol
, vol.63
, pp. 453-460
-
-
Kim, J.M.1
Lee, J.Y.2
Yoon, Y.M.3
Oh, Y.K.4
Youn, J.5
Kim, Y.J.6
-
20
-
-
78649835299
-
A common polymorphism in the interleukin-8 gene promoter is associated with an increased risk for recurrent Clostridium difficile infection
-
Garey KW, Jiang ZD, Ghantoji S, Tam VH, Arora V, Dupont HL. 2010. A common polymorphism in the interleukin-8 gene promoter is associated with an increased risk for recurrent Clostridium difficile infection. Clin Infect Dis 51:1406 –1410. https://doi.org/10.1086/657398.
-
(2010)
Clin Infect Dis
, vol.51
, pp. 1406-1410
-
-
Garey, K.W.1
Jiang, Z.D.2
Ghantoji, S.3
Tam, V.H.4
Arora, V.5
Dupont, H.L.6
-
21
-
-
33646578156
-
A common polymorphism in the interleukin 8 gene promoter is associated with Clostridium difficile diarrhea
-
Jiang ZD, DuPont HL, Garey K, Price M, Graham G, Okhuysen P, Dao-Tran T, LaRocco M. 2006. A common polymorphism in the interleukin 8 gene promoter is associated with Clostridium difficile diarrhea. Am J Gastroenterol 101:1112–1116. https://doi.org/10.1111/j.1572-0241.2006.00482.x.
-
(2006)
Am J Gastroenterol
, vol.101
, pp. 1112-1116
-
-
Jiang, Z.D.1
DuPont, H.L.2
Garey, K.3
Price, M.4
Graham, G.5
Okhuysen, P.6
Dao-Tran, T.7
LaRocco, M.8
-
22
-
-
84855804372
-
Interleukin-15 biology and its therapeutic implications in cancer
-
Steel JC, Waldmann TA, Morris JC. 2012. Interleukin-15 biology and its therapeutic implications in cancer. Trends Pharmacol Sci 33:35–41. https://doi.org/10.1016/j.tips.2011.09.004.
-
(2012)
Trends Pharmacol Sci
, vol.33
, pp. 35-41
-
-
Steel, J.C.1
Waldmann, T.A.2
Morris, J.C.3
-
23
-
-
0028246297
-
Molecular and functional analysis of a lymphocyte chemoattractant factor: Association of biologic function with CD4 expression
-
Cruikshank WW, Center DM, Nisar N, Wu M, Natke B, Theodore AC, Kornfeld H. 1994. Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression. Proc Natl Acad Sci U S A 91:5109–5113. https://doi.org/10.1073/pnas.91.11.5109.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 5109-5113
-
-
Cruikshank, W.W.1
Center, D.M.2
Nisar, N.3
Wu, M.4
Natke, B.5
Theodore, A.C.6
Kornfeld, H.7
-
24
-
-
0031408179
-
IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes
-
Linevsky JK, Pothoulakis C, Keates S, Warny M, Keates AC, Lamont JT, Kelly CP. 1997. IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes. Am J Physiol 273:G13.
-
(1997)
Am J Physiol
, vol.273
, pp. G13
-
-
Linevsky, J.K.1
Pothoulakis, C.2
Keates, S.3
Warny, M.4
Keates, A.C.5
Lamont, J.T.6
Kelly, C.P.7
-
25
-
-
0030909985
-
Early functional effects of Clostridium difficile toxin A on human colonocytes
-
Branka JE, Vallette G, Jarry A, Bou-Hanna C, Lemarre P, Van PN, Laboisse CL. 1997. Early functional effects of Clostridium difficile toxin A on human colonocytes. Gastroenterology 112:1887. https://doi.org/10.1053/gast.1997.v112.pm9178681.
-
(1997)
Gastroenterology
, vol.112
, pp. 1887
-
-
Branka, J.E.1
Vallette, G.2
Jarry, A.3
Bou-Hanna, C.4
Lemarre, P.5
Van, P.N.6
Laboisse, C.L.7
-
26
-
-
0029868433
-
Effect of Clostridium difficile toxin A on human intestinal epithelial cells: Induction of interleukin 8 production and apoptosis after cell detachment
-
Mahida YR, Makh S, Hyde S, Gray T, Borriello SP. 1996. Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment. Gut 38: 337. https://doi.org/10.1136/gut.38.3.337.
-
(1996)
Gut
, vol.38
, pp. 337
-
-
Mahida, Y.R.1
Makh, S.2
Hyde, S.3
Gray, T.4
Borriello, S.P.5
-
27
-
-
0034176003
-
IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production
-
Liu Z, Geboes K, Colpaert S, D’Haens GR, Rutgeerts P, Ceuppens JL. 2000. IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J Immunol 164:3608–3615. https://doi.org/10.4049/jimmunol.164.7.3608.
-
(2000)
J Immunol
, vol.164
, pp. 3608-3615
-
-
Liu, Z.1
Geboes, K.2
Colpaert, S.3
D’Haens, G.R.4
Rutgeerts, P.5
Ceuppens, J.L.6
-
28
-
-
0035062508
-
Increased expression of IL-16 in inflammatory bowel disease
-
Seegert D, Rosenstiel P, Pfahler H, Pfefferkorn P, Nikolaus S, Schreiber S. 2001. Increased expression of IL-16 in inflammatory bowel disease. Gut 48:326–332. https://doi.org/10.1136/gut.48.3.326.
-
(2001)
Gut
, vol.48
, pp. 326-332
-
-
Seegert, D.1
Rosenstiel, P.2
Pfahler, H.3
Pfefferkorn, P.4
Nikolaus, S.5
Schreiber, S.6
-
29
-
-
0033778054
-
Interleukin 16 is up-regulated in Crohn’s disease and participates in TNBS colitis in mice
-
Keates AC, Castagliuolo I, Cruickshank WW, Qiu B, Arseneau KO, Brazer W, Kelly CP. 2000. Interleukin 16 is up-regulated in Crohn’s disease and participates in TNBS colitis in mice. Gastroenterology 119:972–982. https://doi.org/10.1053/gast.2000.18164.
-
(2000)
Gastroenterology
, vol.119
, pp. 972-982
-
-
Keates, A.C.1
Castagliuolo, I.2
Cruickshank, W.W.3
Qiu, B.4
Arseneau, K.O.5
Brazer, W.6
Kelly, C.P.7
-
30
-
-
0030853278
-
Fecal lactoferrin, interleukin-1beta, and interleukin-8 are elevated in patients with severe Clostridium difficile colitis
-
Steiner TS, Flores CA, Pizarro TT, Guerrant RL. 1997. Fecal lactoferrin, interleukin-1beta, and interleukin-8 are elevated in patients with severe Clostridium difficile colitis. Clin Diagn Lab Immunol 4:719–722.
-
(1997)
Clin Diagn Lab Immunol
, vol.4
, pp. 719-722
-
-
Steiner, T.S.1
Flores, C.A.2
Pizarro, T.T.3
Guerrant, R.L.4
-
31
-
-
1342345853
-
Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis
-
Ishida Y, Maegawa T, Kondo T, Kimura A, Iwakura Y, Nakamura S, Mukaida N. 2004. Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis. J Immunol 172:3018–3025. https://doi.org/10.4049/jimmunol.172.5.3018.
-
(2004)
J Immunol
, vol.172
, pp. 3018-3025
-
-
Ishida, Y.1
Maegawa, T.2
Kondo, T.3
Kimura, A.4
Iwakura, Y.5
Nakamura, S.6
Mukaida, N.7
-
32
-
-
78649537405
-
Murine model of Clostridium difficile infection with aged gnotobiotic C57BL/6 mice and a BI/ NAP1 strain
-
Pawlowski SW, Calabrese G, Kolling GL, Platts-Mills J, Freire R, Alcantara Warren C, Liu B, Sartor RB, Guerrant RL. 2010. Murine model of Clostridium difficile infection with aged gnotobiotic C57BL/6 mice and a BI/ NAP1 strain. J Infect Dis 202:1708 –1712. https://doi.org/10.1086/657086.
-
(2010)
J Infect Dis
, vol.202
, pp. 1708-1712
-
-
Pawlowski, S.W.1
Calabrese, G.2
Kolling, G.L.3
Platts-Mills, J.4
Freire, R.5
Alcantara Warren, C.6
Liu, B.7
Sartor, R.B.8
Guerrant, R.L.9
-
33
-
-
0028044948
-
Clostridium difficile colitis
-
Kelly CP, Pothoulakis C, LaMont JT. 1994. Clostridium difficile colitis. N Engl J Med 330:257–262. https://doi.org/10.1056/NEJM199401273300406.
-
(1994)
N Engl J Med
, vol.330
, pp. 257-262
-
-
Kelly, C.P.1
Pothoulakis, C.2
LaMont, J.T.3
-
34
-
-
0022646133
-
Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon
-
Mitchell TJ, Ketley JM, Haslam SC, Stephen J, Burdon DW, Candy DC, Daniel R. 1986. Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon. Gut 27:78–85. https://doi.org/10.1136/gut.27.1.78.
-
(1986)
Gut
, vol.27
, pp. 78-85
-
-
Mitchell, T.J.1
Ketley, J.M.2
Haslam, S.C.3
Stephen, J.4
Burdon, D.W.5
Candy, D.C.6
Daniel, R.7
-
35
-
-
0020029308
-
Effects of the two toxins of Clostridium difficile in antibiotic-associated cecitis in hamsters
-
Libby JM, Jortner BS, Wilkins TD. 1982. Effects of the two toxins of Clostridium difficile in antibiotic-associated cecitis in hamsters. Infect Immun 36:822–829.
-
(1982)
Infect Immun
, vol.36
, pp. 822-829
-
-
Libby, J.M.1
Jortner, B.S.2
Wilkins, T.D.3
-
36
-
-
0021049242
-
Toxin A of Clostridium difficile: Production, purification and effect in mouse intestine
-
Lonnroth I, Lange S. 1983. Toxin A of Clostridium difficile: production, purification and effect in mouse intestine. Acta Pathol Microbiol Immunol Scand B 91:395–400.
-
(1983)
Acta Pathol Microbiol Immunol Scand B
, vol.91
, pp. 395-400
-
-
Lonnroth, I.1
Lange, S.2
-
37
-
-
0030271882
-
Large clostridial cytotoxins–a family of glycosyltransferases modifying small GTP-binding proteins
-
von Eichel-Streiber C, Boquet P, Sauerborn M, Thelestam M. 1996. Large clostridial cytotoxins–a family of glycosyltransferases modifying small GTP-binding proteins. Trends Microbiol 4:375–382. https://doi.org/10.1016/0966-842X(96)10061-5.
-
(1996)
Trends Microbiol
, vol.4
, pp. 375-382
-
-
Von Eichel-Streiber, C.1
Boquet, P.2
Sauerborn, M.3
Thelestam, M.4
-
38
-
-
58549112757
-
Clostridium difficile toxin A promotes dendritic cell maturation and chemokine CXCL2 expression through p38, IKK, and the NF-kappa B signaling pathway
-
Lee JY, Kim H, Cha MY, Park HG, Kim YJ, Kim IY, Kim JM. 2009. Clostridium difficile toxin A promotes dendritic cell maturation and chemokine CXCL2 expression through p38, IKK, and the NF-kappa B signaling pathway. J Mol Med (Berlin) 87:169 –180. https://doi.org/10.1007/s00109-008-0415-2.
-
(2009)
J Mol Med (Berlin)
, vol.87
, pp. 169-180
-
-
Lee, J.Y.1
Kim, H.2
Cha, M.Y.3
Park, H.G.4
Kim, Y.J.5
Kim, I.Y.6
Kim, J.M.7
-
39
-
-
0030987740
-
Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: Role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes
-
Rocha MF, Maia ME, Bezerra LR, Lyerly DM, Guerrant RL, Ribeiro RA, Lima AA. 1997. Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes. Infect Immun 65:2740–2746.
-
(1997)
Infect Immun
, vol.65
, pp. 2740-2746
-
-
Rocha, M.F.1
Maia, M.E.2
Bezerra, L.R.3
Lyerly, D.M.4
Guerrant, R.L.5
Ribeiro, R.A.6
Lima, A.A.7
-
40
-
-
84979775141
-
Glucosylation drives the innate inflammatory response to Clostridium difficile toxin A
-
Cowardin CA, Jackman BM, Noor Z, Burgess SL, Feig AL, Petri WA, Jr. 2016. Glucosylation drives the innate inflammatory response to Clostridium difficile toxin A. Infect Immun 84:2317–2323. https://doi.org/10.1128/IAI.00327-16.
-
(2016)
Infect Immun
, vol.84
, pp. 2317-2323
-
-
Cowardin, C.A.1
Jackman, B.M.2
Noor, Z.3
Burgess, S.L.4
Feig, A.L.5
Petri, W.A.6
-
41
-
-
78049517380
-
Assessment of Clostridium difficile infections by quantitative detection of tcdB toxin by use of a real-time cell analysis system
-
Ryder AB, Huang Y, Li H, Zheng M, Wang X, Stratton CW, Xu X, Tang YW. 2010. Assessment of Clostridium difficile infections by quantitative detection of tcdB toxin by use of a real-time cell analysis system. J Clin Microbiol 48:4129–4134. https://doi.org/10.1128/JCM.01104-10.
-
(2010)
J Clin Microbiol
, vol.48
, pp. 4129-4134
-
-
Ryder, A.B.1
Huang, Y.2
Li, H.3
Zheng, M.4
Wang, X.5
Stratton, C.W.6
Xu, X.7
Tang, Y.W.8
-
42
-
-
17444366186
-
Clostridium difficile toxins: Mechanism of action and role in disease
-
Voth DE, Ballard JD. 2005. Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev 18:247–263. https://doi.org/10.1128/CMR.18.2.247-263.2005.
-
(2005)
Clin Microbiol Rev
, vol.18
, pp. 247-263
-
-
Voth, D.E.1
Ballard, J.D.2
-
43
-
-
84944448131
-
Glucosyltransferase activity of Clostridium difficile toxin B is essential for disease pathogenesis
-
Yang Z, Zhang Y, Huang T, Feng H. 2015. Glucosyltransferase activity of Clostridium difficile toxin B is essential for disease pathogenesis. Gut Microbes 6:221–224. https://doi.org/10.1080/19490976.2015.1062965.
-
(2015)
Gut Microbes
, vol.6
, pp. 221-224
-
-
Yang, Z.1
Zhang, Y.2
Huang, T.3
Feng, H.4
-
44
-
-
84917706337
-
Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice
-
Kim MN, Koh SJ, Kim JM, Im JP, Jung HC, Kim JS. 2014. Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice. World J Gastroenterol 20:17084 –17091. https://doi.org/10.3748/wjg.v20.i45.17084.
-
(2014)
World J Gastroenterol
, vol.20
, pp. 17084-17091
-
-
Kim, M.N.1
Koh, S.J.2
Kim, J.M.3
Im, J.P.4
Jung, H.C.5
Kim, J.S.6
-
45
-
-
84907270863
-
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
-
Xu H, Yang J, Gao W, Li L, Li P, Zhang L, Gong YN, Peng X, Xi JJ, Chen S, Wang F, Shao F. 2014. Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature 513:237–241. https://doi.org/10.1038/nature13449.
-
(2014)
Nature
, vol.513
, pp. 237-241
-
-
Xu, H.1
Yang, J.2
Gao, W.3
Li, L.4
Li, P.5
Zhang, L.6
Gong, Y.N.7
Peng, X.8
Xi, J.J.9
Chen, S.10
Wang, F.11
Shao, F.12
-
46
-
-
77955482224
-
Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome
-
Ng J, Hirota SA, Gross O, Li Y, Ulke-Lemee A, Potentier MS, Schenck LP, Vilaysane A, Seamone ME, Feng H, Armstrong GD, Tschopp J, Macdonald JA, Muruve DA, Beck PL. 2010. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology 139:542–552. https://doi.org/10.1053/j.gastro.2010.04.005.
-
(2010)
Gastroenterology
, vol.139
, pp. 542-552
-
-
Ng, J.1
Hirota, S.A.2
Gross, O.3
Li, Y.4
Ulke-Lemee, A.5
Potentier, M.S.6
Schenck, L.P.7
Vilaysane, A.8
Seamone, M.E.9
Feng, H.10
Armstrong, G.D.11
Tschopp, J.12
Macdonald, J.A.13
Muruve, D.A.14
Beck, P.L.15
-
47
-
-
84868203487
-
Immune responses to Clostridium difficile infection
-
Madan R, Petri WA, Jr. 2012. Immune responses to Clostridium difficile infection. Trends Mol Med 18:658–666. https://doi.org/10.1016/j.molmed.2012.09.005.
-
(2012)
Trends Mol Med
, vol.18
, pp. 658-666
-
-
Madan, R.1
Petri, W.A.2
-
48
-
-
84896738465
-
The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelia barrier dysfunction
-
Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA. 2013. The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelia barrier dysfunction. PLoS One 8:e81491. https://doi.org/10.1371/journal.pone.0081491.
-
(2013)
Plos One
, vol.8
-
-
Hansen, A.1
Alston, L.2
Tulk, S.E.3
Schenck, L.P.4
Grassie, M.E.5
Alhassan, B.F.6
Veermalla, A.T.7
Al-Bashir, S.8
Gendron, F.P.9
Altier, C.10
MacDonald, J.A.11
Beck, P.L.12
Hirota, S.A.13
-
49
-
-
56649108115
-
Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
-
Yang G, Zhou B, Wang J, He X, Sun X, Nie W, Tzipori S, Feng H. 2008. Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium. BMC Microbiol 8:192. https://doi.org/10.1186/1471-2180-8-192.
-
(2008)
BMC Microbiol
, vol.8
, pp. 192
-
-
Yang, G.1
Zhou, B.2
Wang, J.3
He, X.4
Sun, X.5
Nie, W.6
Tzipori, S.7
Feng, H.8
-
50
-
-
84864821779
-
A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection
-
Wang H, Sun X, Zhang Y, Li S, Chen K, Shi L, Nie W, Kumar R, Tzipori S, Wang J, Savidge T, Feng H. 2012. A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infect Immun 80:2679–2688. https://doi.org/10.1128/IAI.00215-12.
-
(2012)
Infect Immun
, vol.80
, pp. 2679-2688
-
-
Wang, H.1
Sun, X.2
Zhang, Y.3
Li, S.4
Chen, K.5
Shi, L.6
Nie, W.7
Kumar, R.8
Tzipori, S.9
Wang, J.10
Savidge, T.11
Feng, H.12
-
51
-
-
0031931516
-
Cytokine production in cell culture by peripheral blood mononuclear cells from immunocompetent host
-
Katial RK, Sachanandani D, Pinney C, Lieberman MM. 1998. Cytokine production in cell culture by peripheral blood mononuclear cells from immunocompetent host. Clin Diagn Lab Immunol 5:78–81.
-
(1998)
Clin Diagn Lab Immunol
, vol.5
, pp. 78-81
-
-
Katial, R.K.1
Sachanandani, D.2
Pinney, C.3
Lieberman, M.M.4
|