Increased expression of IL-16 in inflammatory bowel disease

Gut

Volumn 48, Issue 3, 2001, Pages 326-332

  Seegert, D ^a   Rosenstiel, P ^a   Pfahler, H ^a   Pfefferkorn, P ^a   Nikolaus, S ^a   Schreiber, S ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Crohn's disease; Eosinophils; Inflammatory bowel disease; Interleukin 16; T lymphocytes; Ulcerative colitis

Indexed keywords

INTERLEUKIN 16;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE BIOPSY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULCERATIVE COLITIS;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CASPASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHILS; FEMALE; GENE EXPRESSION; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-16; INTESTINAL MUCOSA; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

EID: 0035062508     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.48.3.326     Document Type: Article

References (34)

1. Modulation of lymphocyte migration by human lymphokines. II. Purification of a lymphotactic factor (LCF)
2. Modulation of lymphocyte migration by human lymphokines. I. Identification and characterization of chemoattractant activity for lymphocytes from mitogen-stimulated mononuclear cells
3. Migration of human helper/inducer T cells in response to supernatants from Con A-stimulated suppressor/cytotoxic T cells
4. Chemoattractant lymphokines specific for the helper/inducer T-lymphocyte subset
5. Tissue and T cell distribution of precursor and mature IL-16
6. Human eosinophils elaborate the lymphocyte chemoattractants. IL-16 (lymphocyte chemoattractant factor) and RANTES
7. Human mast cells produce the CD4+ T lymphocyte chemoattractant factor, IL-16
8. Bronchial epithelial cells of patients with asthma release chemoattractant factors for T lymphocytes
9. Signaling and functional properties of interleukin-16
10. Molecular and functional analysis of a lymphocyte chemoattractant factor: Association of biologic function with CD4 expression
11. Cutting edge: CD4 is not required for the functional activity of IL-16
12. Interleukin-16 stimulates the expression and production of pro-inflammatory cytokines by human monocytes
13. Synergistic activation of CD4+ T cells by IL-16 and IL-2
14. IL-16 activates the SAPK signaling pathway in CD4+ macrophages
15. Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma
16. Cytokines in inflammatory bowel disease
17. Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease
18. Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease
19. Review article: Chemokine production by intestinal epithelial cells: A therapeutic target in inflammatory bowel disease?
20. Processing and activation of pro-interleukin-16 by caspase-3
21. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study
22. Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: A randomised trial
23. Role of interleukin 1 in inflammatory bowel disease - Enhanced production during active disease
24. Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine
25. Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent
26. Enhanced synthesis of neutrophil-activating peptideinterleukin-8 in active ulcerative colitis
27. Interleukin-12 expression is focally enhanced in the gastric mucosa of pediatric patients with Crohn's disease
28. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
29. Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor
30. Histamine-induced secretion of lymphocyte chemoattractant factor from CD8+ T cells is independent of transcription and translation. Evidence for constitutive protein synthesis and storage
31. Secretion of IL-16 (lymphocyte chemoattractant factor) from serotonin-stimulated CD8+ T cells in vitro
32. Processing and release of IL-16 from CD4+ but not CD8+ T cells is activation dependent
33. CD4 antibody treatment in patients with active Crohn's disease: A phase 1 dose finding study
34. A synthetic mimetic of CD4 is able to suppress disease in a rodent model of immune colitis