Severe viral respiratory infections in children with IFIH1 loss-of-function mutations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 31, 2017, Pages 8342-8347

  Asgari, Samira ^a,b   Schlapbach, Luregn J ^c,d,e   Anchisi, Stéphanie ^f   Hammer, Christian ^a,b   Bartha, Istvan ^a,b   Junier, Thomas ^a,b   Mottet Osman, Geneviève ^f   Posfay Barbe, Klara M ^g   Longchamp, David ^h   Stocker, Martin ⁱ   Cordey, Samuel ^j   Kaiser, Laurent ^j   Riedel, Thomas ^e   Kenna, Tony ^k   Long, Deborah ^c,d   Schibler, Andreas ^c,d   Telenti, Amalio ^l   Tapparel, Caroline ^f   McLaren, Paul J ^m,n   Garcin, Dominique ^f   Fellay, Jacques ^a,b   more..

^a EPFL   (Switzerland)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d LADY CILENTO CHILDREN S HOSPITAL   (Australia)

^e UNIVERSITY OF BERN   (Switzerland)

^f UNIVERSITY OF GENEVA   (Switzerland)

^g GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^h LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

ⁱ CHILDREN S HOSPITAL   (Switzerland)

^j UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^k QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^l J CRAIG VENTER INSTITUTE   (United States)

^m PUBLIC HEALTH AGENCY OF CANADA   (Canada)

ⁿ UNIVERSITY OF MANITOBA   (Canada)

more..

Author keywords

IFIH1; Respiratory syncytial virus; Rhinovirus; RIG I like receptor family severe pediatric infectious disease

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BETA INTERFERON; DNA; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; TRANSCRIPTOME; IFIH1 PROTEIN, HUMAN; ISOPROTEIN;

ANTIGEN RECOGNITION; ARTICLE; BRONCHIOLITIS; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; FRAMESHIFT MUTATION; GENE FREQUENCY; GENE IDENTIFICATION; GENE SEQUENCE; GENE TARGETING; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; IMMUNE DEFICIENCY; IN VITRO STUDY; INFANT; INTENSIVE CARE; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PEDIATRIC INTENSIVE CARE UNIT; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN STABILITY; RESPIRATORY SYNCYTIAL VIRUS INFECTION; RNA SEQUENCE; STOP CODON; VIRAL RESPIRATORY TRACT INFECTION; VIRUS REPLICATION; WHOLE EXOME SEQUENCING; BIOSYNTHESIS; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; IMMUNOLOGY; NEWBORN; PNEUMOVIRUS; PRESCHOOL CHILD; PROSPECTIVE STUDY; RESPIRATORY TRACT INFECTION; RHINOVIRUS; VIROLOGY;

ADENOSINE TRIPHOSPHATASES; CHILD, PRESCHOOL; CRITICAL CARE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFANT; INFANT, NEWBORN; INTERFERON-BETA; INTERFERON-INDUCED HELICASE, IFIH1; MALE; PROSPECTIVE STUDIES; PROTEIN ISOFORMS; RESPIRATORY SYNCYTIAL VIRUSES; RESPIRATORY TRACT INFECTIONS; RHINOVIRUS; VIRUS REPLICATION;

EID: 85026787138     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1704259114     Document Type: Article

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