메뉴 건너뛰기




Volumn 7, Issue 1, 2017, Pages

RNA sequencing reveals resistance of TLR4 ligand-activated microglial cells to inflammation mediated by the selective jumonji H3K27 demethylase inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

BENZAZEPINE DERIVATIVE; ENZYME INHIBITOR; GSK-J4; HISTONE DEMETHYLASE; KDM6B PROTEIN, MOUSE; PYRIMIDINE DERIVATIVE; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4;

EID: 85026400351     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-06914-5     Document Type: Article
Times cited : (29)

References (66)
  • 2
    • 78649434414 scopus 로고    scopus 로고
    • Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation
    • Hughes, M. M., Field, R. H., Perry, V. H., Murray, C. L. & Cunningham, C. Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation. Glia 58, 2017-2030 (2010)
    • (2010) Glia , vol.58 , pp. 2017-2030
    • Hughes, M.M.1    Field, R.H.2    Perry, V.H.3    Murray, C.L.4    Cunningham, C.5
  • 3
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C. & Gage, F. H. Mechanisms underlying inflammation in neurodegeneration. Cell 140, 918-934 (2010)
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 4
    • 84903269246 scopus 로고    scopus 로고
    • Innate immune activation in neurodegenerative disease
    • Heneka, M. T., Kummer, M. P. & Latz, E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol 14, 463-477 (2014)
    • (2014) Nat Rev Immunol , vol.14 , pp. 463-477
    • Heneka, M.T.1    Kummer, M.P.2    Latz, E.3
  • 5
    • 33745292215 scopus 로고    scopus 로고
    • A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia
    • Lehnardt, S. et al. A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol 177, 583-592 (2006)
    • (2006) J Immunol , vol.177 , pp. 583-592
    • Lehnardt, S.1
  • 6
    • 84874594801 scopus 로고    scopus 로고
    • Suppression of LPS-induced inflammatory responses by inflexanin B in BV2 microglial cells
    • Lim, J. Y. et al. Suppression of LPS-induced inflammatory responses by inflexanin B in BV2 microglial cells. Can J Physiol Pharmacol 91, 141-148 (2013)
    • (2013) Can J Physiol Pharmacol , vol.91 , pp. 141-148
    • Lim, J.Y.1
  • 7
    • 70350754328 scopus 로고    scopus 로고
    • Jmjd3 contributes to the control of gene expression in LPS-activated macrophages
    • De Santa, F. et al. Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J 28, 3341-3352 (2009)
    • (2009) EMBO J , vol.28 , pp. 3341-3352
    • De Santa, F.1
  • 8
    • 84931833419 scopus 로고    scopus 로고
    • Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process
    • Salminen, A., Kaarniranta, K., Hiltunen, M. & Kauppinen, A. Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process. J Mol Med (Berl) 92, 1035-1043 (2014)
    • (2014) J Mol Med (Berl) , vol.92 , pp. 1035-1043
    • Salminen, A.1    Kaarniranta, K.2    Hiltunen, M.3    Kauppinen, A.4
  • 9
    • 70350435962 scopus 로고    scopus 로고
    • Epigenetic regulation of the alternatively activated macrophage phenotype
    • Ishii, M. et al. Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 114, 3244-3254 (2009)
    • (2009) Blood , vol.114 , pp. 3244-3254
    • Ishii, M.1
  • 10
    • 84865120905 scopus 로고    scopus 로고
    • A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
    • Kruidenier, L. et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488, 404-408 (2012)
    • (2012) Nature , vol.488 , pp. 404-408
    • Kruidenier, L.1
  • 11
    • 84907526739 scopus 로고    scopus 로고
    • Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
    • Ntziachristos, P. et al. Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia. Nature 514, 513-517 (2014)
    • (2014) Nature , vol.514 , pp. 513-517
    • Ntziachristos, P.1
  • 12
    • 84961291627 scopus 로고    scopus 로고
    • Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
    • Hashizume, R. et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med 20, 1394-1396 (2014)
    • (2014) Nat Med , vol.20 , pp. 1394-1396
    • Hashizume, R.1
  • 13
    • 78751570979 scopus 로고    scopus 로고
    • RNA sequencing: Advances, challenges and opportunities
    • Ozsolak, F. & Milos, P. M. RNA sequencing: advances, challenges and opportunities. Nat Rev Genet 12, 87-98 (2011)
    • (2011) Nat Rev Genet , vol.12 , pp. 87-98
    • Ozsolak, F.1    Milos, P.M.2
  • 14
    • 45549088326 scopus 로고    scopus 로고
    • The transcriptional landscape of the yeast genome defined by RNA sequencing
    • Nagalakshmi, U. et al. The transcriptional landscape of the yeast genome defined by RNA sequencing. Science 320, 1344-1349 (2008)
    • (2008) Science , vol.320 , pp. 1344-1349
    • Nagalakshmi, U.1
  • 15
    • 79251644774 scopus 로고    scopus 로고
    • Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease
    • Twine, N. A., Janitz, K., Wilkins, M. R. & Janitz, M. Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease. PLoS One 6, e16266 (2011)
    • (2011) PLoS One , vol.6 , pp. e16266
    • Twine, N.A.1    Janitz, K.2    Wilkins, M.R.3    Janitz, M.4
  • 16
    • 84926215948 scopus 로고    scopus 로고
    • Dual RNA sequencing reveals the expression of unique transcriptomic signatures in lipopolysaccharide-induced BV-2 microglial cells
    • Das, A. et al. Dual RNA sequencing reveals the expression of unique transcriptomic signatures in lipopolysaccharide-induced BV-2 microglial cells. PLoS One 10, e0121117 (2015)
    • (2015) PLoS One , vol.10 , pp. e0121117
    • Das, A.1
  • 17
    • 84977614161 scopus 로고    scopus 로고
    • Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia
    • Das, A. et al. Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia. J Neuroinflammation 13, 182 (2016)
    • (2016) J Neuroinflammation , vol.13 , pp. 182
    • Das, A.1
  • 18
    • 33750627921 scopus 로고    scopus 로고
    • The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions
    • Lund, S. et al. The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions. J Neuroimmunol 180, 71-87 (2006)
    • (2006) J Neuroimmunol , vol.180 , pp. 71-87
    • Lund, S.1
  • 19
    • 33645839000 scopus 로고    scopus 로고
    • Gene expression profile of activated microglia under conditions associated with dopamine neuronal damage
    • Thomas, D. M., Francescutti-Verbeem, D. M. & Kuhn, D. M. Gene expression profile of activated microglia under conditions associated with dopamine neuronal damage. FASEB J 20, 515-517 (2006)
    • (2006) FASEB J , vol.20 , pp. 515-517
    • Thomas, D.M.1    Francescutti-Verbeem, D.M.2    Kuhn, D.M.3
  • 20
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da, W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4, 44-57 (2009)
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 21
    • 84936754279 scopus 로고    scopus 로고
    • Transcriptome sequencing of microglial cells stimulated with TLR3 and TLR4 ligands
    • Das, A. et al. Transcriptome sequencing of microglial cells stimulated with TLR3 and TLR4 ligands. BMC Genomics 16, 517 (2015)
    • (2015) BMC Genomics , vol.16 , pp. 517
    • Das, A.1
  • 22
    • 58149350049 scopus 로고    scopus 로고
    • Differential expression of the type i interferon pathway during persistent and transient bovine viral diarrhea virus infection
    • Shoemaker, M. L. et al. Differential expression of the type I interferon pathway during persistent and transient bovine viral diarrhea virus infection. J Interferon Cytokine Res 29, 23-35 (2009)
    • (2009) J Interferon Cytokine Res , vol.29 , pp. 23-35
    • Shoemaker, M.L.1
  • 23
    • 84155176729 scopus 로고    scopus 로고
    • Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice
    • Salem, M., Mony, J. T., Lobner, M., Khorooshi, R. & Owens, T. Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice. J Neuroinflammation 8, 181 (2011)
    • (2011) J Neuroinflammation , vol.8 , pp. 181
    • Salem, M.1    Mony, J.T.2    Lobner, M.3    Khorooshi, R.4    Owens, T.5
  • 24
    • 84859972127 scopus 로고    scopus 로고
    • JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
    • O'Shea, J. J. & Plenge, R. JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity 36, 542-550 (2012)
    • (2012) Immunity , vol.36 , pp. 542-550
    • O'Shea, J.J.1    Plenge, R.2
  • 25
    • 67849114236 scopus 로고    scopus 로고
    • Pscan: Finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes
    • Zambelli, F., Pesole, G. & Pavesi, G. Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes. Nucleic Acids Res 37, W247-252 (2009)
    • (2009) Nucleic Acids Res , vol.37 , pp. W247-252
    • Zambelli, F.1    Pesole, G.2    Pavesi, G.3
  • 26
    • 84894571860 scopus 로고    scopus 로고
    • Causal analysis approaches in Ingenuity Pathway Analysis
    • Kramer, A., Green, J., Pollard, J. Jr. & Tugendreich, S. Causal analysis approaches in Ingenuity Pathway Analysis. Bioinformatics 30, 523-530 (2014)
    • (2014) Bioinformatics , vol.30 , pp. 523-530
    • Kramer, A.1    Green, J.2    Pollard, J.3    Tugendreich, S.4
  • 27
    • 84898038159 scopus 로고    scopus 로고
    • The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia
    • Przanowski, P. et al. The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia. J Mol Med (Berl) 92, 239-254 (2014)
    • (2014) J Mol Med (Berl) , vol.92 , pp. 239-254
    • Przanowski, P.1
  • 28
    • 84873289305 scopus 로고    scopus 로고
    • Heat shock protein 70: Roles in multiple sclerosis
    • Mansilla, M. J., Montalban, X. & Espejo, C. Heat shock protein 70: roles in multiple sclerosis. Mol Med 18, 1018-1028 (2012)
    • (2012) Mol Med , vol.18 , pp. 1018-1028
    • Mansilla, M.J.1    Montalban, X.2    Espejo, C.3
  • 29
    • 84926646109 scopus 로고    scopus 로고
    • Hsp70 regulates immune response in experimental autoimmune encephalomyelitis
    • Mansilla, M. J. et al. Hsp70 regulates immune response in experimental autoimmune encephalomyelitis. PLoS One 9, e105737 (2014)
    • (2014) PLoS One , vol.9 , pp. e105737
    • Mansilla, M.J.1
  • 30
    • 0034954215 scopus 로고    scopus 로고
    • Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions
    • Lee, J. E. et al. Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions. Exp Neurol 170, 129-139 (2001)
    • (2001) Exp Neurol , vol.170 , pp. 129-139
    • Lee, J.E.1
  • 31
    • 84921277179 scopus 로고    scopus 로고
    • Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation
    • Kim, J. Y., Yenari, M. A. & Lee, J. E. Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation. Neuroscience 286, 272-280 (2015)
    • (2015) Neuroscience , vol.286 , pp. 272-280
    • Kim, J.Y.1    Yenari, M.A.2    Lee, J.E.3
  • 32
    • 84867317736 scopus 로고    scopus 로고
    • Effects of heat shock protein 72 (Hsp72) on evolution of astrocyte activation following stroke in the mouse
    • Barreto, G. E., White, R. E., Xu, L., Palm, C. J. & Giffard, R. G. Effects of heat shock protein 72 (Hsp72) on evolution of astrocyte activation following stroke in the mouse. Exp Neurol 238, 284-296 (2012)
    • (2012) Exp Neurol , vol.238 , pp. 284-296
    • Barreto, G.E.1    White, R.E.2    Xu, L.3    Palm, C.J.4    Giffard, R.G.5
  • 33
    • 78651299939 scopus 로고    scopus 로고
    • Time-course expression of metallothioneins and tissue metals in chronic relapsing form of experimental autoimmune encephalomyelitis
    • Jakovac, H. et al. Time-course expression of metallothioneins and tissue metals in chronic relapsing form of experimental autoimmune encephalomyelitis. Histol Histopathol 26, 233-245 (2011)
    • (2011) Histol Histopathol , vol.26 , pp. 233-245
    • Jakovac, H.1
  • 34
    • 84874610368 scopus 로고    scopus 로고
    • Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease
    • Mealer, R. G., Subramaniam, S. & Snyder, S. H. Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease. J Neurosci 33, 4206-4210 (2013)
    • (2013) J Neurosci , vol.33 , pp. 4206-4210
    • Mealer, R.G.1    Subramaniam, S.2    Snyder, S.H.3
  • 35
    • 84930959044 scopus 로고    scopus 로고
    • Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease
    • Swarnkar, S. et al. Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease. Neurobiol Dis 82, 66-77 (2015)
    • (2015) Neurobiol Dis , vol.82 , pp. 66-77
    • Swarnkar, S.1
  • 36
    • 84892511644 scopus 로고    scopus 로고
    • Large-scale gene function analysis with the PANTHER classification system
    • Mi, H., Muruganujan, A., Casagrande, J. T. & Thomas, P. D. Large-scale gene function analysis with the PANTHER classification system. Nat Protoc 8, 1551-1566 (2013)
    • (2013) Nat Protoc , vol.8 , pp. 1551-1566
    • Mi, H.1    Muruganujan, A.2    Casagrande, J.T.3    Thomas, P.D.4
  • 38
    • 84914118716 scopus 로고    scopus 로고
    • Targeting histone lysine demethylases-progress, challenges, and the future
    • Thinnes, C. C. et al. Targeting histone lysine demethylases-progress, challenges, and the future. Biochim Biophys Acta 1839, 1416-1432 (2014)
    • (2014) Biochim Biophys Acta , vol.1839 , pp. 1416-1432
    • Thinnes, C.C.1
  • 39
    • 84893745524 scopus 로고    scopus 로고
    • Identification of a unique TGF-beta-dependent molecular and functional signature in microglia
    • Butovsky, O. et al. Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci 17, 131-143 (2014)
    • (2014) Nat Neurosci , vol.17 , pp. 131-143
    • Butovsky, O.1
  • 40
    • 77649273140 scopus 로고    scopus 로고
    • Role of chemokines in CNS health and pathology: A focus on the CCL2/CCR2 and CXCL8/CXCR2 networks
    • Semple, B. D., Kossmann, T. & Morganti-Kossmann, M. C. Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks. J Cereb Blood Flow Metab 30, 459-473 (2010)
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 459-473
    • Semple, B.D.1    Kossmann, T.2    Morganti-Kossmann, M.C.3
  • 41
    • 18144415513 scopus 로고    scopus 로고
    • Involvement of beta-chemokines in the development of inflammatory demyelination
    • Banisor, I., Leist, T. P. & Kalman, B. Involvement of beta-chemokines in the development of inflammatory demyelination. J Neuroinflammation 2, 7 (2005)
    • (2005) J Neuroinflammation , vol.2 , pp. 7
    • Banisor, I.1    Leist, T.P.2    Kalman, B.3
  • 42
    • 84923926855 scopus 로고    scopus 로고
    • The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion
    • He, S. et al. The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion. Mol Cancer Res 13, 380-390 (2015)
    • (2015) Mol Cancer Res , vol.13 , pp. 380-390
    • He, S.1
  • 43
    • 77955090022 scopus 로고    scopus 로고
    • The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases
    • Conductier, G., Blondeau, N., Guyon, A., Nahon, J. L. & Rovere, C. The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases. J Neuroimmunol 224, 93-100 (2010)
    • (2010) J Neuroimmunol , vol.224 , pp. 93-100
    • Conductier, G.1    Blondeau, N.2    Guyon, A.3    Nahon, J.L.4    Rovere, C.5
  • 44
    • 33845680613 scopus 로고    scopus 로고
    • IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia
    • Qin, H., Wilson, C. A., Lee, S. J. & Benveniste, E. N. IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia. FASEB J 20, 985-987 (2006)
    • (2006) FASEB J , vol.20 , pp. 985-987
    • Qin, H.1    Wilson, C.A.2    Lee, S.J.3    Benveniste, E.N.4
  • 45
    • 84933498604 scopus 로고    scopus 로고
    • CD40-CD40 Ligand Pathway is a Major Component of Acute Neuroinflammation and Contributes to Long-term Cognitive Dysfunction after Sepsis
    • Michels, M. et al. CD40-CD40 Ligand Pathway is a Major Component of Acute Neuroinflammation and Contributes to Long-term Cognitive Dysfunction after Sepsis. Mol Med 21, 219-226 (2015)
    • (2015) Mol Med , vol.21 , pp. 219-226
    • Michels, M.1
  • 46
    • 33646045379 scopus 로고    scopus 로고
    • CXCL10 is the key ligand for CXCR3 on CD8 + effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system
    • Christensen, J. E., de Lemos, C., Moos, T., Christensen, J. P. & Thomsen, A. R. CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. J Immunol 176, 4235-4243 (2006)
    • (2006) J Immunol , vol.176 , pp. 4235-4243
    • Christensen, J.E.1    De Lemos, C.2    Moos, T.3    Christensen, J.P.4    Thomsen, A.R.5
  • 47
    • 33745726874 scopus 로고    scopus 로고
    • The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells
    • Shen, Q. et al. The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci 9, 743-751 (2006)
    • (2006) Nat Neurosci , vol.9 , pp. 743-751
    • Shen, Q.1
  • 48
    • 84890806562 scopus 로고    scopus 로고
    • Therapeutic targeting of the Jak/STAT pathway
    • Aittomaki, S. & Pesu, M. Therapeutic targeting of the Jak/STAT pathway. Basic Clin Pharmacol Toxicol 114, 18-23 (2014)
    • (2014) Basic Clin Pharmacol Toxicol , vol.114 , pp. 18-23
    • Aittomaki, S.1    Pesu, M.2
  • 50
    • 77955499638 scopus 로고    scopus 로고
    • Injury-induced type i IFN signaling regulates inflammatory responses in the central nervous system
    • Khorooshi, R. & Owens, T. Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system. J Immunol 185, 1258-1264 (2010)
    • (2010) J Immunol , vol.185 , pp. 1258-1264
    • Khorooshi, R.1    Owens, T.2
  • 51
    • 84927177593 scopus 로고    scopus 로고
    • Is there new hope for therapeutic matrix metalloproteinase inhibition
    • Vandenbroucke, R. E. & Libert, C. Is there new hope for therapeutic matrix metalloproteinase inhibition Nat Rev Drug Discov 13, 904-927 (2014)
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 904-927
    • Vandenbroucke, R.E.1    Libert, C.2
  • 52
    • 59149106645 scopus 로고    scopus 로고
    • Matrix metalloproteinase-13 is activated and is found in the nucleus of neural cells after cerebral ischemia
    • Cuadrado, E. et al. Matrix metalloproteinase-13 is activated and is found in the nucleus of neural cells after cerebral ischemia. J Cereb Blood Flow Metab 29, 398-410 (2009)
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 398-410
    • Cuadrado, E.1
  • 53
    • 34249062904 scopus 로고    scopus 로고
    • G protein-coupled receptor 84, a microglia-associated protein expressed in neuroinflammatory conditions
    • Bouchard, C., Page, J., Bedard, A., Tremblay, P. & Vallieres, L. G protein-coupled receptor 84, a microglia-associated protein expressed in neuroinflammatory conditions. Glia 55, 790-800 (2007)
    • (2007) Glia , vol.55 , pp. 790-800
    • Bouchard, C.1    Page, J.2    Bedard, A.3    Tremblay, P.4    Vallieres, L.5
  • 54
    • 84877325058 scopus 로고    scopus 로고
    • Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation
    • Xiao, Y. et al. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med 19, 595-602 (2013)
    • (2013) Nat Med , vol.19 , pp. 595-602
    • Xiao, Y.1
  • 55
    • 0034655155 scopus 로고    scopus 로고
    • TNF-alpha gene expression in macrophages: Regulation by NF-kappa B is independent of c-Jun or C/EBP beta
    • Liu, H. et al. TNF-alpha gene expression in macrophages: regulation by NF-kappa B is independent of c-Jun or C/EBP beta. J Immunol 164, 4277-4285 (2000)
    • (2000) J Immunol , vol.164 , pp. 4277-4285
    • Liu, H.1
  • 56
    • 33646560337 scopus 로고    scopus 로고
    • Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: Independence from endogenous TNF-alpha and platelet-activating factor
    • De Plaen, I. G. et al. Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor. Immunology 118, 153-163 (2006)
    • (2006) Immunology , vol.118 , pp. 153-163
    • De Plaen, I.G.1
  • 57
    • 0035444539 scopus 로고    scopus 로고
    • Signal transduction by tumor necrosis factor and its relatives
    • Baud, V. & Karin, M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 11, 372-377 (2001)
    • (2001) Trends Cell Biol , vol.11 , pp. 372-377
    • Baud, V.1    Karin, M.2
  • 58
    • 84995477377 scopus 로고    scopus 로고
    • The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs
    • Donas, C. et al. The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs. J Autoimmun (2016)
    • (2016) J Autoimmun
    • Donas, C.1
  • 59
    • 80052938984 scopus 로고    scopus 로고
    • Microglia cell culture: A primer for the novice
    • Witting, A. & Moller, T. Microglia cell culture: a primer for the novice. Methods Mol Biol 758, 49-66 (2011)
    • (2011) Methods Mol Biol , vol.758 , pp. 49-66
    • Witting, A.1    Moller, T.2
  • 60
    • 84862770361 scopus 로고    scopus 로고
    • Efficient isolation of live microglia with preserved phenotypes from adult mouse brain
    • Nikodemova, M. & Watters, J. J. Efficient isolation of live microglia with preserved phenotypes from adult mouse brain. J Neuroinflammation 9, 147 (2012)
    • (2012) J Neuroinflammation , vol.9 , pp. 147
    • Nikodemova, M.1    Watters, J.J.2
  • 61
    • 77955540457 scopus 로고    scopus 로고
    • Resveratrol differentially modulates inflammatory responses of microglia and astrocytes
    • Lu, X. et al. Resveratrol differentially modulates inflammatory responses of microglia and astrocytes. J Neuroinflammation 7, 46 (2010)
    • (2010) J Neuroinflammation , vol.7 , pp. 46
    • Lu, X.1
  • 62
    • 84905049901 scopus 로고    scopus 로고
    • Trimmomatic: A flexible trimmer for Illumina sequence data
    • Bolger, A. M., Lohse, M. & Usadel, B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30, 2114-2120 (2014)
    • (2014) Bioinformatics , vol.30 , pp. 2114-2120
    • Bolger, A.M.1    Lohse, M.2    Usadel, B.3
  • 63
    • 84871809302 scopus 로고    scopus 로고
    • STAR: Ultrafast universal RNA-seq aligner
    • Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15-21 (2013)
    • (2013) Bioinformatics , vol.29 , pp. 15-21
    • Dobin, A.1
  • 64
    • 84924629414 scopus 로고    scopus 로고
    • Moderated estimation of fold change and dispersion for RNA-seq data with DESeq. 2
    • Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq. 2. Genome Biol 15, 550 (2014)
    • (2014) Genome Biol , vol.15 , pp. 550
    • Love, M.I.1    Huber, W.2    Anders, S.3
  • 65
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38, 576-589 (2010)
    • (2010) Mol Cell , vol.38 , pp. 576-589
    • Heinz, S.1
  • 66
    • 75549083247 scopus 로고    scopus 로고
    • JASPAR 2010: The greatly expanded open-access database of transcription factor binding profiles
    • Portales-Casamar, E. et al. JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles. Nucleic Acids Res 38, D105-110 (2010).
    • (2010) Nucleic Acids Res , vol.38 , pp. D105-110
    • Portales-Casamar, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.