The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia

Journal of Molecular Medicine

Volumn 92, Issue 3, 2014, Pages 239-254

  Przanowski, Piotr ^a   Dabrowski, Michal ^a   Ellert Miklaszewska, Aleksandra ^a   Kloss, Michal ^a   Mieczkowski, Jakub ^a   Kaza, Beata ^a   Ronowicz, Anna ^b   Hu, Feng ^c   Piotrowski, Arkadiusz ^b   Kettenmann, Helmut ^c   Komorowski, Jan ^d,e   Kaminska, Bozena ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d UPPSALA UNIVERSITY   (Sweden)

^e UNIVERSITY OF WARSAW   (Poland)

Author keywords

Brain macrophages; ChIP chip; Inflammation; Jmjd3 H3K27me3 histone demethylase; Signal transducers and activators of transcription

Indexed keywords

GAMMA INTERFERON; HISTONE DEMETHYLASE; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 6; JMJD3 PROTEIN; LIPOPOLYSACCHARIDE; PROTEIN KINASE PIM 1; RANTES; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL STIMULATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVITY; EZR GENE; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENETIC REGULATION; GENETIC TRANSCRIPTION; GENOME; GENOMICS; IFIH1 GENE; INFLAMMATION; MICROGLIA; MICROGLIAL CELL CULTURE; NONHUMAN; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION; UBA7 GENE;

ANIMALS; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CYTOKINES; GENE EXPRESSION REGULATION; GENE SILENCING; HISTONES; INFLAMMATION; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; LIPOPOLYSACCHARIDES; LYSINE; METHYLATION; MICROGLIA; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; RATS; RATS, WISTAR; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR;

EID: 84898038159     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-013-1090-5     Document Type: Article

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