A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression

Cell

Volumn 170, Issue 3, 2017, Pages 522-533.e15

  Gupta, Rajat M ^a,b   Hadaya, Joseph ^a   Trehan, Aditi ^a   Zekavat, Seyedeh M ^a   Roselli, Carolina ^a   Klarin, Derek ^a   Emdin, Connor A ^a   Hilvering, Catharina R E ^c   Bianchi, Valerio ^c   Mueller, Christian ^d   Khera, Amit V ^a,b   Ryan, Russell J H ^a,b   Engreitz, Jesse M ^a   Issner, Robbyn ^a   Shoresh, Noam ^a   Epstein, Charles B ^a   de Laat, Wouter ^c   Brown, Jonathan D ^e   Schnabel, Renate B ^d   Bernstein, Bradley E ^a,b   Kathiresan, Sekar ^a,b   more..

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY HEART CENTER HAMBURG   (Germany)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

cardiovascular diseases; coronary artery disease; endothelial cells; endothelin 1; epigenomics; genetic enhancer elements; genome wide association study; hypertension; migraine disorders; SNP

Indexed keywords

ENDOTHELIN 1; CHROMATIN; HISTONE;

ADULT; ARTERIAL STIFFNESS; ARTICLE; CAUSAL ATTRIBUTION; CHROMATIN STRUCTURE; CHROMOSOME 6; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; ENDOTHELIN 1 GENE; ENDOTHELIUM CELL; EPIGENETICS; FEMALE; GENE DELETION; GENE EDITING; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENE LOCUS; GENE MAPPING; GENETIC DISTANCE; GENETIC VARIABILITY; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION; VASCULAR DISEASE; ACETYLATION; BLOOD; CELL CULTURE; CHROMATIN; CHROMOSOMAL MAPPING; CORONARY ARTERY DISEASE; CYTOLOGY; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; VASCULAR SMOOTH MUSCLE;

ACETYLATION; CELLS, CULTURED; CHROMATIN; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 6; CORONARY ARTERY DISEASE; ENDOTHELIAL CELLS; ENDOTHELIN-1; EPIGENOMICS; GENE EDITING; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HISTONES; HUMANS; MUSCLE, SMOOTH, VASCULAR; POLYMORPHISM, SINGLE NUCLEOTIDE; VASCULAR DISEASES;

EID: 85026362170     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.06.049     Document Type: Article

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