Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis

Biochimie

Volumn 93, Issue 10, 2011, Pages 1668-1675

  Jarray, Rafika ^a,f   Allain, Barbara ^a,b,f   Borriello, Lucia ^a,b   Biard, Denis ^c   Loukaci, Ali ^a   Larghero, Jérôme ^a,d,e   Hadj Slimane, Réda ^b   Garbay, Christiane ^a   Lepelletier, Yves ^a   Raynaud, Françoise ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b TRAGEX Pharma   (France)

^c INSTITUT DE RADIOBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

^d SAINT LOUIS HOSPITAL   (France)

^e INSERM   (France)

^f Hôpital Saint Louis ^*  (France)

Author keywords

Cell death receptor apoptosis; PHACTR 1; siRNA; Tube formation

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CASPASE 3; CASPASE 8; DEATH RECEPTOR 4; DEATH RECEPTOR 5; F ACTIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PHOSPHATASE ACTIN REGULATING PROTEIN 1; PROCASPASE 3; PROTEIN BAD; PROTEIN BAX; REGULATOR PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN 165;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL DEATH; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; DNA SYNTHESIS; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RNA PURIFICATION; SUPPRESSION SUBTRACTIVE HYBRIDIZATION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

EID: 80052081312     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.07.010     Document Type: Article

References (24)

1. P. Carmeliet Angiogenesis in life, disease and medicine Nature 438 2005 932 936 (Pubitemid 43093958)
2. W. Risau Mechanisms of angiogenesis Nature 386 1997 671 674 (Pubitemid 27193480)
3. R.S. Kerbel Tumor angiogenesis N. Engl. J. Med. 358 2008 2039 2049 (Pubitemid 351656458)
4. J. Folkman Angiogenesis Annu. Rev. Med. 57 2006 1 18 (Pubitemid 43261975)
5. F.S. Grunewald, A.E. Prota, A. Giese, and K. Ballmer-Hofer Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling Biochim. Biophys. Acta 1804 2010 567 580
6. R. Roskoski Jr. Vascular endothelial growth factor (VEGF) signaling in tumor progression Crit. Rev. Oncol. Hematol. 62 2007 179 213 (Pubitemid 46679285)
7. S.J. Harper, and D.O. Bates VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat. Rev. Cancer 8 2008 880 887
8. N. Ferrara Vascular endothelial growth factor: basic science and clinical progress Endocr. Rev. 25 2004 581 611 (Pubitemid 39099316)
9. D.R. Senger, S.J. Galli, and A.M. Dvorak Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid Science 219 1983 983 985
10. P.J. Keck, S.D. Hauser, and G. Krivi Vascular permeability factor, an endothelial cell mitogen related to PDGF Science 246 1989 1309 1312 (Pubitemid 20066717)
11. R.M. Perrin, O. Konopatskaya, and Y. Qiu Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor Diabetologia 48 2005 2422 2427 (Pubitemid 41618935)
12. F. Nussenbaum, and I.M. Herman Tumor angiogenesis: insights and innovations J. Oncol. 2010 132641
13. R. Roskoski Jr. VEGF receptor protein-tyrosine kinases: structure and regulation Biochem. Biophys. Res. Commun. 375 2008 287 291
14. A.K. Olsson, A. Dimberg, J. Kreuger, and L. Claesson-Welsh VEGF receptor signalling - in control of vascular function Nat. Rev. Mol. Cell Biol. 7 2006 359 371
15. S. Cebe-Suarez, F.S. Grunewald, and R. Jaussi Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR FASEB J. 22 2008 3078 3086
16. J.P. Vert, N. Foveau, C. Lajaunie, and Y. Vandenbrouck An accurate and interpretable model for siRNA efficacy prediction BMC Bioinformatics 7 2006 520
17. P. Pamonsinlapatham, B. Gril, and S. Dufour Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration Cell Signal 20 2008 2119 2126
18. L. Diatchenko, Y.F. Lau, and A.P. Campbell Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries Proc. Natl. Acad. Sci. U.S.A. 93 1996 6025 6030 (Pubitemid 26190796)
19. J. Sagara, T. Higuchi, and Y. Hattori Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure J. Biol. Chem. 278 2003 45611 45619 (Pubitemid 37432703)
20. P.B. Allen, A.T. Greenfield, P. Svenningsson, D.C. Haspeslagh, and P. Greengard Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins Proc. Natl. Acad. Sci. U.S.A. 101 2004 7187 7192 (Pubitemid 38596464)
21. J. Bankovic, J. Stojsic, and D. Jovanovic Identification of genes associated with non-small-cell lung cancer promotion and progression Lung Cancer 67 2010 151 159
22. T.H. Kim, J. Goodman, K.V. Anderson, and L. Niswander Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression Develop. Cell 13 2007 87 102 (Pubitemid 46991577)
23. S. Elmore Apoptosis: a review of programmed cell death Toxicol. Pathol. 35 2007 495 516 (Pubitemid 46911891)
24. S. Cory, and J.M. Adams The Bcl2 family: regulators of the cellular life-or-death switch Nat. Rev. Cancer 2 2002 647 656 (Pubitemid 37328916)