Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration

Cell Stem Cell

Volumn 21, Issue 3, 2017, Pages 383-398.e7

  Xiang, Yangfei ^a   Tanaka, Yoshiaki ^a   Patterson, Benjamin ^a   Kang, Young Jin ^b   Govindaiah, Gubbi ^b   Roselaar, Naomi ^a   Cakir, Bilal ^a   Kim, Kun Yong ^a   Lombroso, Adam P ^c   Hwang, Sung Min ^a   Zhong, Mei ^a   Stanley, Edouard G ^d,e,f   Elefanty, Andrew G ^d,e,f   Naegele, Janice R ^c   Lee, Sang Hun ^b   Weissman, Sherman M ^a   Park, In Hyun ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c WESLEYAN UNIVERSITY   (United States)

^d ROYAL CHILDREN'S HOSPITAL   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f MONASH UNIVERSITY   (Australia)

Author keywords

ATAC seq; brain organoid; cortex; fusion; hESC; interneuron; MGE; neuronal migration; single cell RNA seq; transcriptional regulation

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; BETA TUBULIN; CALCIUM; EOMESODERMIN; GEPHYRIN; HIGH MOBILITY GROUP B2 PROTEIN; HISTONE H3; MYOSIN II; NERVE CELL ADHESION MOLECULE; NEUROPEPTIDE Y; PARVALBUMIN; SOMATOSTATIN; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTOME; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 2; VESICULAR INHIBITORY AMINO ACID TRANSPORTER;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CELL; BRAIN CORTEX; BRAIN DEVELOPMENT; CELL CULTURE; CELL CYCLE; CELL MIGRATION; CELL POPULATION; CHROMATIN; CILIUM; CONTROLLED STUDY; DENDRITE; DOWN REGULATION; ENERGY METABOLISM; FETUS; GANGLION; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; INTERNEURON; MEDIAL GANGLIONIC EMINENCE; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NEWBORN; NONHUMAN; OLIGODENDROCYTE PROGENITOR; OLIGODENDROGLIA; PLURIPOTENT STEM CELL; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE; SYNAPSE; WNT SIGNALING; BIOLOGICAL MODEL; BRAIN; CELL DIFFERENTIATION; CELL LINEAGE; CELL MOTION; CYTOLOGY; EMBRYOLOGY; GENETICS; MEDIAN EMINENCE; METABOLISM; ORGANOID; SEQUENCE ANALYSIS;

BRAIN; CELL DIFFERENTIATION; CELL LINEAGE; CELL MOVEMENT; CEREBRAL CORTEX; CHROMATIN; HUMANS; INTERNEURONS; MEDIAN EMINENCE; MODELS, BIOLOGICAL; ORGANOIDS; PLURIPOTENT STEM CELLS; SEQUENCE ANALYSIS, RNA; TRANSCRIPTOME;

EID: 85026230642     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2017.07.007     Document Type: Article

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