Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 12, 2016, Pages 3185-3190

  Zhang, Zhen Ning ^a   Freitas, Beatriz C ^b,c   Qian, Hao ^c,d   Lux, Jacques ^a,g   Acab, Allan ^b,c   Trujillo, Cleber A ^b,c   Herai, Roberto H ^b,c,h   Huu, Viet Anh Nguyen ^a   Wen, Jessica H ^e   Joshi Barr, Shivanjali ^a   Karpiak, Jerome V ^b,c   Engler, Adam J ^e,f   Fu, Xiang Dong ^c,d   Muotri, Alysson R ^b,c   Almutairi, Adah ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b RADY CHILDREN'S HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f SANFORD CONSORTIUM FOR REGENERATIVE MEDICINE   (United States)

^g UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^h PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

3D hydrogels; 3D RTT modeling; Neuronal migration and maturation

Indexed keywords

4 AMINOBUTYRIC ACID; BETA TUBULIN; CHEMOKINE RECEPTOR CXCR4; CYCLIN DEPENDENT KINASE LIKE 5; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE DECARBOXYLASE 67; HERMES ANTIGEN; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN 2; NESTIN; PROTEIN S100B; SYNAPSIN; SYNAPSIN I; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX1; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; MECP2 PROTEIN, HUMAN;

ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL INTERACTION; CELL MATURATION; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; EXCITATORY POSTSYNAPTIC POTENTIAL; GENOTYPE; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEURAL STEM CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETT SYNDROME; STOP CODON; SYNAPSE; SYNAPTOGENESIS; THREE DIMENSIONAL IMAGING; CELL MOTION; CYTOLOGY; INDUCED PLURIPOTENT STEM CELL; METABOLISM; NERVE CELL; PHYSIOLOGY;

CELL MOVEMENT; HUMANS; HYDROGELS; INDUCED PLURIPOTENT STEM CELLS; METHYL-CPG-BINDING PROTEIN 2; NEURONS;

EID: 84962294715     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1521255113     Document Type: Article

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