메뉴 건너뛰기




Volumn 7, Issue 1, 2017, Pages

Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; GLUCOSE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PEPTIDE CHLOROMETHYL KETONE; RALBP1 PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, MOUSE; SMALL INTERFERING RNA;

EID: 85025591565     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-06088-0     Document Type: Article
Times cited : (96)

References (44)
  • 1
    • 84964047906 scopus 로고    scopus 로고
    • Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke
    • Winek, K. et al. Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke. Stroke. 47(5), 1354-1363, doi:10. 1161/STROKEAHA. 115. 011800 (2016).
    • (2016) Stroke. , vol.47 , Issue.5 , pp. 1354-1363
    • Winek, K.1
  • 2
    • 84962287139 scopus 로고    scopus 로고
    • An antagomir to microRNA-106b-5p ameliorates cerebral ischemia and reperfusion injury in rats via inhibiting apoptosis and oxidative stress
    • Li, P. et al. An antagomir to microRNA-106b-5p ameliorates cerebral ischemia and reperfusion injury in rats via inhibiting apoptosis and oxidative stress. Mol Neurobiol. 54(4), 2901-2921, doi:10. 1007/s12035-016-9842-1 (2017).
    • (2017) Mol Neurobiol. , vol.54 , Issue.4 , pp. 2901-2921
    • Li, P.1
  • 3
    • 84931377023 scopus 로고    scopus 로고
    • The diverse role of RIP kinases in necroptosis and inflammation
    • Silke, J., Rickard, J. A. & Gerlic, M. The diverse role of RIP kinases in necroptosis and inflammation. Nat Immunol. 16(7), 689-697, doi:10. 1038/ni. 3206 (2015).
    • (2015) Nat Immunol. , vol.16 , Issue.7 , pp. 689-697
    • Silke, J.1    Rickard, J.A.2    Gerlic, M.3
  • 4
    • 50249132439 scopus 로고    scopus 로고
    • Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice
    • You, Z. et al. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 28(9), 1564-1573, doi:10. 1038/jcbfm. 2008. 44 (2008).
    • (2008) J Cereb Blood Flow Metab. , vol.28 , Issue.9 , pp. 1564-1573
    • You, Z.1
  • 5
    • 77956619262 scopus 로고    scopus 로고
    • Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury
    • Xu, X. et al. Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury. Brain Res. 1355, 189-194, doi:10. 1016/j. brainres. 2010. 07. 080 (2010).
    • (2010) Brain Res. , vol.1355 , pp. 189-194
    • Xu, X.1
  • 6
    • 84864240409 scopus 로고    scopus 로고
    • The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
    • Li, J. et al. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 150(2), 339-350, doi:10. 1016/j. cell. 2012. 06. 019 (2012).
    • (2012) Cell. , vol.150 , Issue.2 , pp. 339-350
    • Li, J.1
  • 7
    • 84862907788 scopus 로고    scopus 로고
    • Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
    • Sun, L. et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 148(1-2), 213-227, doi:10. 1016/j. cell. 2011. 11. 031 (2012).
    • (2012) Cell. , vol.148 , Issue.1-2 , pp. 213-227
    • Sun, L.1
  • 8
    • 84913533544 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1? Mediates neuroprotection of hypoxic postconditioning against global cerebral ischemia
    • Zhu, T. et al. Hypoxia-inducible factor 1? mediates neuroprotection of hypoxic postconditioning against global cerebral ischemia. J. Neuropathol Exp Neurol. 73(10), 975-986, doi:10. 1097/NEN. 0000000000000118 (2014).
    • (2014) J. Neuropathol Exp Neurol. , vol.73 , Issue.10 , pp. 975-986
    • Zhu, T.1
  • 9
    • 84887143993 scopus 로고    scopus 로고
    • Evidence that collaboration between HIF-1? and Notch-1 promotes neuronal cell death in ischemic stroke
    • Cheng, Y. L. et al. Evidence that collaboration between HIF-1? and Notch-1 promotes neuronal cell death in ischemic stroke. Neurobiol Dis. 62, 286-295, doi:10. 1016/j. nbd. 2013. 10. 009 (2014).
    • (2014) Neurobiol Dis. , vol.62 , pp. 286-295
    • Cheng, Y.L.1
  • 10
    • 85009767255 scopus 로고    scopus 로고
    • Cannabidiol attenuates OGD/R-induced damage by enhancinxg mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons
    • Sun, S., Hu, F., Wu, J. & Zhang, S. Cannabidiol attenuates OGD/R-induced damage by enhancinxg mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons. Redox Biol. 11, 577-585, doi:10. 1016/j. redox. 2016. 12. 029 (2017).
    • (2017) Redox Biol. , vol.11 , pp. 577-585
    • Sun, S.1    Hu, F.2    Wu, J.3    Zhang, S.4
  • 11
    • 85014939886 scopus 로고    scopus 로고
    • Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment
    • Trueman, R. C. et al. Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment. J Cereb Blood Flow Metab 37(4), 1349-1361, doi:10. 1177/0271678X16654921 (2017).
    • (2017) J Cereb Blood Flow Metab , vol.37 , Issue.4 , pp. 1349-1361
    • Trueman, R.C.1
  • 12
    • 84959317374 scopus 로고    scopus 로고
    • Isoquercetin ameliorates cerebral impairment in focal ischemia through anti-oxidative, anti-inflammatory, and anti-apoptotic effects in primary culture of rat hippocampal neurons and hippocampal ca1 region of rats
    • Wang, C. P. et al. Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats. Mol Neurobiol. 54(3), 2126-2142, doi:10. 1007/s12035-016-9806-5 (2017).
    • (2017) Mol Neurobiol. , vol.54 , Issue.3 , pp. 2126-2142
    • Wang, C.P.1
  • 13
    • 85017308205 scopus 로고    scopus 로고
    • TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats
    • Ma, X. D. et al. TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats. Exp Neurol. 293, 115-123, doi:10. 1016/j. expneurol. 2017. 03. 023 (2017).
    • (2017) Exp Neurol. , vol.293 , pp. 115-123
    • Ma, X.D.1
  • 14
    • 84988662474 scopus 로고    scopus 로고
    • The Mechanism of Long Non-coding RNA MEG3 for Neurons Apoptosis Caused by Hypoxia: Mediated by miR-181b-12/15-LOX Signaling Pathway
    • Liu, X. et al. The Mechanism of Long Non-coding RNA MEG3 for Neurons Apoptosis Caused by Hypoxia: Mediated by miR-181b-12/15-LOX Signaling Pathway. Front Cell Neurosci. 10, 201, doi:10. 3389/fncel. 2016. 00201 (2016).
    • (2016) Front Cell Neurosci. , vol.10 , pp. 201
    • Liu, X.1
  • 15
    • 84961383063 scopus 로고    scopus 로고
    • Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway
    • Lin-Holderer, J., Li, L., Gruneberg, D., Marti, H. H. & Kunze, R. Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway. Neuropharmacology. 105, 228-240, doi:10. 1016/j. neuropharm. 2016. 01. 023 (2016).
    • (2016) Neuropharmacology. , vol.105 , pp. 228-240
    • Lin-Holderer, J.1    Li, L.2    Gruneberg, D.3    Marti, H.H.4    Kunze, R.5
  • 16
    • 84976230252 scopus 로고    scopus 로고
    • Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia
    • Marutani, E. et al. Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia. J Am Heart Assoc. 4(11), e002125, doi:10. 1161/JAHA. 115. 002125 (2015).
    • (2015) J Am Heart Assoc. , vol.4 , Issue.11 , pp. e002125
    • Marutani, E.1
  • 17
    • 84948434132 scopus 로고    scopus 로고
    • Enriched endogenous Omega-3 polyunsaturated fatty acids protect cortical neurons from experimental ischemic injury
    • Shi, Z. et al. Enriched endogenous Omega-3 polyunsaturated fatty acids protect cortical neurons from experimental ischemic injury. Mol Neurobiol. 53(9), 6482-6488, doi:10. 1007/s12035-015-9554-y (2016).
    • (2016) Mol Neurobiol. , vol.53 , Issue.9 , pp. 6482-6488
    • Shi, Z.1
  • 18
    • 84954546140 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I modulates endothelial blood-brain barrier function in ischemic middle-aged female rats
    • Bake, S. et al. Insulin-like growth factor (IGF)-I modulates endothelial blood-brain barrier function in ischemic middle-aged female rats. Endocrinology. 157(1), 61-69, doi:10. 1210/en. 2015-1840 (2016).
    • (2016) Endocrinology. , vol.157 , Issue.1 , pp. 61-69
    • Bake, S.1
  • 19
    • 84962176700 scopus 로고    scopus 로고
    • Mesenchymal stem cells protect neurons against hypoxic-ischemic injury via inhibiting parthanatos, necroptosis, and apoptosis, but not autophagy
    • Kong, D. et al. Mesenchymal stem cells protect neurons against hypoxic-ischemic injury via inhibiting parthanatos, necroptosis, and apoptosis, but not autophagy. Cell Mol Neurobiol. 37(2), 303-313, doi:10. 1007/s10571-016-0370-3 (2017).
    • (2017) Cell Mol Neurobiol. , vol.37 , Issue.2 , pp. 303-313
    • Kong, D.1
  • 20
    • 84968538437 scopus 로고    scopus 로고
    • RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
    • Newton, K. et al. RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury. Cell Death Differ. 23(9), 1565-1576, doi:10. 1038/cdd. 2016. 46 (2016).
    • (2016) Cell Death Differ. , vol.23 , Issue.9 , pp. 1565-1576
    • Newton, K.1
  • 21
    • 84961137335 scopus 로고    scopus 로고
    • MLKL inhibition attenuates hypoxia-ischemia induced neuronal damage in developing brain
    • Qu, Y. et al. MLKL inhibition attenuates hypoxia-ischemia induced neuronal damage in developing brain. Exp Neurol. 279, 223-231, doi:10. 1016/j. expneurol. 2016. 03. 011 (2016).
    • (2016) Exp Neurol. , vol.279 , pp. 223-231
    • Qu, Y.1
  • 22
    • 77953512054 scopus 로고    scopus 로고
    • Suppression of hypoxia-inducible factor-1 alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia
    • Chen, C. et al. Suppression of hypoxia-inducible factor-1 alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia. J Neurosci Res. 88(9), 2046-55, doi:10. 1002/jnr. 22361 (2010).
    • (2010) J Neurosci Res. , vol.88 , Issue.9 , pp. 2046-2055
    • Chen, C.1
  • 23
    • 78650952230 scopus 로고    scopus 로고
    • Characterisation of neuronal cell death in acute and delayed in vitro ischemia (oxygen-glucose deprivation) models
    • Meloni, B. P. et al. Characterisation of neuronal cell death in acute and delayed in vitro ischemia (oxygen-glucose deprivation) models. J Neurosci Methods. 195(1), 67-74, doi:10. 1016/j. jneumeth. 2010. 11. 023 (2011).
    • (2011) J Neurosci Methods. , vol.195 , Issue.1 , pp. 67-74
    • Meloni, B.P.1
  • 24
    • 84908615923 scopus 로고    scopus 로고
    • Inflammatory response and neuronal necrosis in rats with cerebral ischemia
    • Wu, L. et al. Inflammatory response and neuronal necrosis in rats with cerebral ischemia. Neural Regen Res. 9(19), 1753-1762, doi:10. 4103/1673-5374. 143419 (2014).
    • (2014) Neural Regen Res. , vol.9 , Issue.19 , pp. 1753-1762
    • Wu, L.1
  • 25
    • 84989260397 scopus 로고    scopus 로고
    • Necroptosis is a key mediator of enterocytes loss in intestinal ischaemia/reperfusion injury
    • Wen, S. et al. Necroptosis is a key mediator of enterocytes loss in intestinal ischaemia/reperfusion injury. J Cell Mol Med 2016, 12987, doi:10. 1111/jcmm. 12987 (2016).
    • (2016) J Cell Mol Med , vol.2016 , pp. 12987
    • Wen, S.1
  • 26
    • 77957105977 scopus 로고    scopus 로고
    • Molecular mechanisms of necroptosis: An ordered cellular explosion
    • Vandenabeele, P. et al. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol. 11(10), 700-714, doi:10. 1038/nrm2970 (2010).
    • (2010) Nat Rev Mol Cell Biol. , vol.11 , Issue.10 , pp. 700-714
    • Vandenabeele, P.1
  • 27
    • 84893867149 scopus 로고    scopus 로고
    • Necroptosis: Molecular signalling and translational implications
    • Giampietri, C. et al. Necroptosis: molecular signalling and translational implications. Int J Cell Biol 2014, 490275, doi:10. 1155/2014/490275 (2014).
    • (2014) Int J Cell Biol , vol.2014 , pp. 490275
    • Giampietri, C.1
  • 28
    • 84891739370 scopus 로고    scopus 로고
    • Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
    • Chen, X. et al. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 24(1), 105-121, doi:10. 1038/cr. 2013. 171 (2014).
    • (2014) Cell Res. , vol.24 , Issue.1 , pp. 105-121
    • Chen, X.1
  • 29
    • 84879298446 scopus 로고    scopus 로고
    • Changes in HIF-1?, VEGF, NGF and BDNF levels in cerebrospinal fluid and their relationship with cognitive impairment in patients with cerebral infarction
    • Ke, X. J. & Zhang, J. J. Changes in HIF-1?, VEGF, NGF and BDNF levels in cerebrospinal fluid and their relationship with cognitive impairment in patients with cerebral infarction. J Huazhong Univ Sci Technolog Med Sci. 33(3), 433-437, doi:10. 1007/s11596-013-1137-4 (2013).
    • (2013) J Huazhong Univ Sci Technolog Med Sci. , vol.33 , Issue.3 , pp. 433-437
    • Ke, X.J.1    Zhang, J.J.2
  • 30
    • 65249129300 scopus 로고    scopus 로고
    • IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke
    • Chen, W. Y. & Chang, M. S. IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke. J Immunol. 182(8), 5003-5012, doi:10. 4049/jimmunol. 0803653 (2009).
    • (2009) J Immunol. , vol.182 , Issue.8 , pp. 5003-5012
    • Chen, W.Y.1    Chang, M.S.2
  • 31
    • 84865595109 scopus 로고    scopus 로고
    • Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke
    • Wang, Z. et al. Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke. Stroke. 43(9), 2430-2436, doi:10. 1161/STROKEAHA. 112. 652545 (2012).
    • (2012) Stroke. , vol.43 , Issue.9 , pp. 2430-2436
    • Wang, Z.1
  • 32
    • 84940092659 scopus 로고    scopus 로고
    • Pre-and posttreatment with edaravone protects CA1 hippocampus and enhances neurogenesis in the subgranular zone of dentate gyrus after transient global cerebral ischemia in rats
    • Lei, S. et al. Pre-and posttreatment with edaravone protects CA1 hippocampus and enhances neurogenesis in the subgranular zone of dentate gyrus after transient global cerebral ischemia in rats. ASN Neuro 6(6), 1-15, doi:10. 1177/1759091414558417 (2014).
    • (2014) ASN Neuro , vol.6 , Issue.6 , pp. 1-15
    • Lei, S.1
  • 33
    • 70450278715 scopus 로고    scopus 로고
    • Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway
    • Koshikawa, N. et al. Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. J Biol Chem 284(48), 33185-33194, doi:10. 1074/jbc. M109. 054221 (2009).
    • (2009) J Biol Chem , vol.284 , Issue.48 , pp. 33185-33194
    • Koshikawa, N.1
  • 34
    • 52049112539 scopus 로고    scopus 로고
    • Baicalein suppresses hypoxia-induced HIF-1alpha protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells
    • Hwang, K. Y. et al. Baicalein suppresses hypoxia-induced HIF-1alpha protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells. Neurosci Lett. 444(3), 264-269, doi:10. 1016/j. neulet. 2008. 08. 057 (2008).
    • (2008) Neurosci Lett. , vol.444 , Issue.3 , pp. 264-269
    • Hwang, K.Y.1
  • 35
    • 67650812332 scopus 로고    scopus 로고
    • RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
    • Zhang, D. W. et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science. 325(5938), 332-336, doi:10. 1126/science. 1172308 (2009).
    • (2009) Science. , vol.325 , Issue.5938 , pp. 332-336
    • Zhang, D.W.1
  • 36
    • 67650638892 scopus 로고    scopus 로고
    • RIP kinases at the crossroads of cell death and survival
    • Declercq, W., Vanden, B. T. & Vandenabeele, P. RIP kinases at the crossroads of cell death and survival. Cell. 138(2), 229-232, doi:10. 1016/j. cell. 2009. 07. 006 (2009).
    • (2009) Cell. , vol.138 , Issue.2 , pp. 229-232
    • Declercq, W.1    Vanden, B.T.2    Vandenabeele, P.3
  • 37
    • 84879356157 scopus 로고    scopus 로고
    • Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells
    • Huang, C. Y. et al. Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells. Cell Death Dis 4, e622, doi:10. 1038/cddis. 2013. 149 (2013).
    • (2013) Cell Death Dis , vol.4 , pp. e622
    • Huang, C.Y.1
  • 38
    • 85018214795 scopus 로고    scopus 로고
    • Inhibiting histone deacetylase 6 partly protects cultured rat cortical neurons from oxygen-glucose deprivation?induced necroptosis
    • Yuan, L. et al. Inhibiting histone deacetylase 6 partly protects cultured rat cortical neurons from oxygen-glucose deprivation?induced necroptosis. Mol Med Rep 12(2), 2661-2667, doi:10. 3892/mmr. 2015. 3779 (2015).
    • (2015) Mol Med Rep , vol.12 , Issue.2 , pp. 2661-2667
    • Yuan, L.1
  • 39
    • 84966326704 scopus 로고    scopus 로고
    • N-myc downstream-regulated gene 2 (ndrg2) is involved in ischemia-hypoxia-induced astrocyte apoptosis: A novel target for stroke therapy
    • Ma, Y. L. et al. N-Myc Downstream-Regulated Gene 2 (Ndrg2) Is Involved in Ischemia-Hypoxia-Induced Astrocyte Apoptosis: a Novel Target for Stroke Therapy. Mol Neurobiol. 54(5), 3286-3299, doi:10. 1007/s12035-016-9814-5 (2017).
    • (2017) Mol Neurobiol. , vol.54 , Issue.5 , pp. 3286-3299
    • Ma, Y.L.1
  • 40
    • 84876429613 scopus 로고    scopus 로고
    • Nelfinavir inhibits intra-mitochondrial calcium influx and protects brain against hypoxic-ischemic injury in neonatal mice
    • Utkina-Sosunova, I. V. et al. Nelfinavir inhibits intra-mitochondrial calcium influx and protects brain against hypoxic-ischemic injury in neonatal mice. PLoS One. 8(4), e62448, doi:10. 1371/journal. pone. 0062448 (2013).
    • (2013) PLoS One. , vol.8 , Issue.4 , pp. e62448
    • Utkina-Sosunova, I.V.1
  • 41
    • 84963762637 scopus 로고    scopus 로고
    • Monocyte-derived macrophages contribute to spontaneous long-term functional recovery after stroke in mice
    • Wattananit, S. et al. Monocyte-derived macrophages contribute to spontaneous long-term functional recovery after stroke in mice. J Neurosci. 36(15), 4182-4195, doi:10. 1523/JNEUROSCI. 4317-15. 2016 (2016).
    • (2016) J Neurosci. , vol.36 , Issue.15 , pp. 4182-4195
    • Wattananit, S.1
  • 42
    • 39149095272 scopus 로고    scopus 로고
    • Combinatorial-approached neuroprotection using pan-caspase inhibitor and poly (ADP-ribose) polymerase (PARP) inhibitor following experimental stroke in rats; Is there additional benefit?
    • Yap, E. et al. Combinatorial-approached neuroprotection using pan-caspase inhibitor and poly (ADP-ribose) polymerase (PARP) inhibitor following experimental stroke in rats; is there additional benefit? Brain Res. 1195, 130-138, doi:10. 1016/j. brainres. 2007. 12. 024 (2008).
    • (2008) Brain Res , vol.1195 , pp. 130-138
    • Yap, E.1
  • 43
    • 84964199296 scopus 로고    scopus 로고
    • Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat
    • Liu, T. et al. Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat. Sci Rep 6, 24547, doi:10. 1038/srep24547 (2016).
    • (2016) Sci Rep , vol.6 , pp. 24547
    • Liu, T.1
  • 44
    • 84891617782 scopus 로고    scopus 로고
    • Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition
    • Wang, N. et al. Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. Neuropharmacology. 79, 282-289, doi:10. 1016/j. neuropharm. 2013. 12. 004 (2014).
    • (2014) Neuropharmacology. , vol.79 , pp. 282-289
    • Wang, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.